Sprycel and Gastro Problems

[Guest guest]

Dear Friends,

On Thursday evening I was hospitalized with intense vomiting, diarrhea, and low

grade fever. I had taken my eighth dose of Sprycel earlier that day after

switching from Gleevec due to G250E mutation.

WBC had dropped to 2800 bySaturday and I'm scheduled to meet with my doctor at

MSKCC on Wednesday.

The hospital docs were unable to give me a conclusive diagnosis as to whether

the problem was a result of viral gastroenteritis or side effects from the

Sprycel.

I really do not want to switch from Sprycel to Tasigna since some of you have

already advised me that Sprycel is more effective against G250E than Tasigna.

Have any of you experienced gastro problems with Sprycel and, if so, how did you

deal with the issue? What questions should I be asking my doc at this point.?

Many thanks for you suggestions and recommendations.

Best wishes,

Carl

---------------------------------

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[Guest guest]

I think sometimes we have a tendency to think everything that happens to us

is a result of our medication. Maybe you picked up a flu bug-there are so

many going around. I had severe diarrhea for a month-losing 15 pounds - my

Dr. had me go off Sprycel for a full week and then back on it. It worked.

But of course a few years later I did come down with Plural Effusion and

other bad side affects. But I would not give up on Sprycel, if I were you.

I was doing so well on it..But now I go on to Tasigna.

I just want you to remember that we do still get all the bugs that go

around. It is so difficult to tell what the reasons are-the meds we take or

just something we would have gotten had we not been on our medication

Sharon

_____

From: [mailto: ] On Behalf Of Carl

Davies

Sent: Sunday, March 09, 2008 9:20 AM

; asiancmlsupportgroup ;

cmlhopegooglegroups

Subject: [ ] Sprycel and Gastro Problems

Dear Friends,

On Thursday evening I was hospitalized with intense vomiting, diarrhea, and

low grade fever. I had taken my eighth dose of Sprycel earlier that day

after switching from Gleevec due to G250E mutation.

WBC had dropped to 2800 bySaturday and I'm scheduled to meet with my doctor

at MSKCC on Wednesday.

The hospital docs were unable to give me a conclusive diagnosis as to

whether the problem was a result of viral gastroenteritis or side effects

from the Sprycel.

I really do not want to switch from Sprycel to Tasigna since some of you

have already advised me that Sprycel is more effective against G250E than

Tasigna.

Have any of you experienced gastro problems with Sprycel and, if so, how did

you deal with the issue? What questions should I be asking my doc at this

point.? Many thanks for you suggestions and recommendations.

Best wishes,

Carl

---------------------------------

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