Guest guest Posted March 9, 2008 Report Share Posted March 9, 2008 On pregnancy and gleevec Blood has a new article : http://tinyurl.com/2yqqs4 I have never read anything about us males wanting kids and gleevec. The only thing is, if you have an idea on what got you into the cml, exposure to radiations (previous cancer treatment, work related, etc), or chemicals like benzene, are known to cause cml, you should talk about it with a specialist. These kinds of contamination are also known to also provoke birth defects. But the vast majority of people who have cml haven't been contaminated by any of the above, so if nothing comes to mind the odds are low. I would think this could be dealt with some extra care in the follow up of the featus. Marcos. On Sat, Mar 8, 2008 at 9:41 PM, Lottie Duthu <lotajam@...> wrote: > > > > > Dear Ray, > I think Tracey has answered your question, but I do know of several people > who successfully brought healthy babies to term. The men should check with > their doctors how long to stay off Gleevec before attempting to impregnate > their wives. The women of course, is a whole different story. There have > been quite a few women with CML who were brave enough to go for it, but they > had to stay off Gleevec the entire pregnancy. Some have had more than 1 > pregnancy. > The researchers present the experience accumulated to date in 19 pregnancies > involving 18 patients (10 women and 8 men) with CML who conceived while > receiving imatinib -- the standard therapy for CML. All of the women stopped > imatinib treatment immediately after learning they were pregnant. Three of > the 19 pregnancies ended in spontaneous abortions (16%), including 2 (20%) > of the 10 pregnancies in female patients. " This rate is somewhat higher than > the reported rate of spontaneous abortions in the general population of > approximately 10% to 15%, " the team notes. " Thus, it is possible that the > brief exposure to imatinib may slightly increase the risk of spontaneous > abortions. " http://www.medscape.com/viewarticle/528742 > > You might also want to view and listen to this about 2nd line therapies, > although it has nothing to do with pregnancy: > Myelogenous Leukemia (Slides with Audio) CME/CNCCN 2nd Annual Congress: > Hematologic Malignancies - Update on Primary Therapy, Second-Line Therapy, > and New Agents for Chronic E Jerald P. Radich, MD > http://www.medscape.com/viewarticle/564100 > > Wishing you well, always, > Lottie > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 9, 2008 Report Share Posted March 9, 2008 In an older paper (http://tinyurl.com/2rbqyk) something about gleevec and male fertility : " There was no evidence that imatinib was clastogenic or mutagenic, thus imatinib is not felt to be genotoxic, and spermatozoa are expected to be qualitatively normal. However, spermatogenesis was impaired in rats, dogs, and monkeys. This observation raised concern that men treated with imatinib may have reduced sperm counts. Clinical experience thus far has not shown this to be true. Although sperm counts were not required for assessment of toxicities in Study 106, inadequate sperm counts have not been reported. One patient was found to have a low-normal sperm count during an infertility work-up. With continued imatinib therapy, the count improved somewhat and conception occurred without medical intervention. A second patient had a normal sperm count while taking imatinib prior to banking sperm. In addition, among men being treated on clinical trials, there are reports of 13 pregnancies in the partners of men on imatinib, providing additional support that spermatogenesis is not impaired. Five additional pregnancies in partners of men taking imatinib have been reported from patients treated outside of clinical trials. The outcomes of these pregnancies are detailed in Table 5: Table 5. Outcomes of Pregnancies Among Partners of Men Treated With Imatinib Clinical trials 13 pregnancies in partners of male patients on imatinib: 8 chronic-phase CML (400 mg); 4 accelerated CML (600 mg); 1 GIST (800 mg) ¡ü 4 normal infants ¡ü 2 pregnancies ongoing ¡ü 2 therapeutic abortion on social grounds (normal abortus) ¡ü 1 spontaneous abortion ¡ü 1 death in utero at 13 weeks ¡ü 3 no information Nonclinical trial spontaneous reports 5 pregnancies with limited information (4 ongoing) They state these numbers correspond to those of the general population. Marcos. On Sat, Mar 8, 2008 at 10:30 PM, Marcos Perreau Guimaraes <montereyunderwater@...> wrote: > On pregnancy and gleevec Blood has a new article : > http://tinyurl.com/2yqqs4 > > I have never read anything about us males wanting kids and gleevec. > The only thing is, if you have an idea on what got you into the cml, > exposure to radiations (previous cancer treatment, work related, etc), > or chemicals like benzene, are known to cause cml, you should talk > about it with a specialist. These kinds of contamination are also > known to also provoke birth defects. But the vast majority of people > who have cml haven't been contaminated by any of the above, so if > nothing comes to mind the odds are low. I would think this could be > dealt with some extra care in the follow up of the featus. > Marcos. > > > On Sat, Mar 8, 2008 at 9:41 PM, Lottie Duthu <lotajam@...> wrote: > > > > > > > > > > Dear Ray, > > I think Tracey has answered your question, but I do know of several people > > who successfully brought healthy babies to term. The men should check with > > their doctors how long to stay off Gleevec before attempting to impregnate > > their wives. The women of course, is a whole different story. There have > > been quite a few women with CML who were brave enough to go for it, but they > > had to stay off Gleevec the entire pregnancy. Some have had more than 1 > > pregnancy. > > The researchers present the experience accumulated to date in 19 pregnancies > > involving 18 patients (10 women and 8 men) with CML who conceived while > > receiving imatinib -- the standard therapy for CML. All of the women stopped > > imatinib treatment immediately after learning they were pregnant. Three of > > the 19 pregnancies ended in spontaneous abortions (16%), including 2 (20%) > > of the 10 pregnancies in female patients. " This rate is somewhat higher than > > the reported rate of spontaneous abortions in the general population of > > approximately 10% to 15%, " the team notes. " Thus, it is possible that the > > brief exposure to imatinib may slightly increase the risk of spontaneous > > abortions. " http://www.medscape.com/viewarticle/528742 > > > > You might also want to view and listen to this about 2nd line therapies, > > although it has nothing to do with pregnancy: > > Myelogenous Leukemia (Slides with Audio) CME/CNCCN 2nd Annual Congress: > > Hematologic Malignancies - Update on Primary Therapy, Second-Line Therapy, > > and New Agents for Chronic E Jerald P. Radich, MD > > http://www.medscape.com/viewarticle/564100 > > > > Wishing you well, always, > > Lottie > > > > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.