Is Diamox contraindicated with Inspra?

[Guest guest]

Since Diamox is a carbonic anhydrase inhibitor which can cause

hypokalemia can it be taken with Inspra an Aldosterone Receptor

Antagonist and Aldosterone Blocker if I want to use Diamox for

prevention of high altitude sickness?

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Diamox (Acetazolamide)

Mechanism

Carbonic Anhydrase Inhibitor

Indications

High Altitude Sickness treatment and prevention

Pseudotumor Cerebri

Contraindications

Sulfonamide allergy

Dosing

High Altitude Sickness

Prevention: 125 mg PO bid

Start 24 hours before ascent

Continue for 72 hours

Insomnia at altitude: 125 mg PO qhs

Treatment: 250 to 400 mg PO bid

Pseudotumor Cerebri

Dose range: 125-250 mg PO qd-tid

Adverse Effects

Peripheral Paresthesias

Polyuria

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Inspra (Eplerenone)

Selective Aldosterone Receptor Antagonist

Selective Aldosterone Blocker

More selective for aldosterone than Spironolactone

Indication

Congestive Heart Failure

Hypertension

Contraindications

Serum Potassium >5.5 mEq/L

Tyep II Diabetes Mellitus with Microalbuminuria

Renal insufficiency

Serum Creatinine >2.0 in men or >1.8 mg/dl in women

Creatinine Clearance <50 ml/min

Adverse Effects

Hyperkalemia

Hypertriglyceridemia

Hyponatremia

Dizziness

Fatigue

Diarrhea

Cough

Less Gynecomastia and Impotence than Spironolactone

Drug Interactions

Potassium supplements

Potassium sparing Diuretics

Cytochrome P450 3A4 inhibitors (e.g. Ketoconazole)

ACE Inhibitors