[Paracelsus] Feverfew Extract Reduces Migraine Frequency (fwd)

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Subject: [Paracelsus] Feverfew Extract Reduces Migraine Frequency

Feverfew Extract Reduces Migraine Frequency

By

http://www.medscape.com/viewarticle/518057

NEW YORK (Reuters Health) Nov 29 - A feverfew extract obtained using

supercritical carbon dioxide (MIG-99) appears particularly effective in

migraine prevention, German researchers report in the November issue of

Cephalalgia.

As lead investigator Dr. Hans-Christoph Diener told Reuters Health,

" Feverfew in the form of MIG-99 is an effective and safe prophylactic

treatment of frequent migraine attacks "

Dr. Diener of the University of Essen and colleagues note that feverfew

has traditionally been used to treat migraine, and placebo-controlled

trials of the powdered herb have shown promising results.

However, tests using ethanol extracts have been less successful, and the

MIG-99 formulation was developed in order to provide an enriched and

stable product.

To evaluate the agent, the researchers conducted a double-blind trial in

170 migraine patients. At baseline, migraine frequency was a mean of

4.76 attacks over a 4-week period.

The subjects were then randomized to MIG-99 6.25 mg, three times a day

or to placebo for up to 16 weeks.

In the active treatment group, migraine frequency fell by 1.9 attacks

per month. In the placebo patients, the corresponding decrease was 1.3

per month.

Possible medication-related adverse events occurred in about 8.4% of

MIG-99 patients and 10.2% of placebo patients.

The researchers point out that logistic regression analysis of responder

rates gave an odds ratio in favor of MIG-99 of 3.4, and they conclude

that the extract is effective and has a favorable benefit-risk ratio.

Cephalalgia 2005;25:1031-1041.

--

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> Subject: [Paracelsus] Feverfew Extract Reduces Migraine Frequency

>

>

> Feverfew Extract Reduces Migraine Frequency

>

> By

> http://www.medscape.com/viewarticle/518057

>

> NEW YORK (Reuters Health) Nov 29 - A feverfew extract obtained

using

> supercritical carbon dioxide (MIG-99) appears particularly

effective in

> migraine prevention, German researchers report in the November

issue of

> Cephalalgia.

>

> As lead investigator Dr. Hans-Christoph Diener told Reuters Health,

> " Feverfew in the form of MIG-99 is an effective and safe

prophylactic

> treatment of frequent migraine attacks "

>

> Dr. Diener of the University of Essen and colleagues note that

feverfew

> has traditionally been used to treat migraine, and placebo-

controlled

> trials of the powdered herb have shown promising results.

>

> However, tests using ethanol extracts have been less successful,

and the

> MIG-99 formulation was developed in order to provide an enriched

and

> stable product.

>

> To evaluate the agent, the researchers conducted a double-blind

trial in

> 170 migraine patients. At baseline, migraine frequency was a mean

of

> 4.76 attacks over a 4-week period.

>

> The subjects were then randomized to MIG-99 6.25 mg, three times a

day

> or to placebo for up to 16 weeks.

>

> In the active treatment group, migraine frequency fell by 1.9

attacks

> per month. In the placebo patients, the corresponding decrease was

1.3

> per month.

>

> Possible medication-related adverse events occurred in about 8.4%

of

> MIG-99 patients and 10.2% of placebo patients.

>

> The researchers point out that logistic regression analysis of

responder

> rates gave an odds ratio in favor of MIG-99 of 3.4, and they

conclude

> that the extract is effective and has a favorable benefit-risk

ratio.

>

> Cephalalgia 2005;25:1031-1041.

> --

>