Cultivation of fungi from fecal specimens in cases of antibiotic associated diar

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[Cultivation of fungi from fecal specimens in cases of antibiotic associated

diarrhea (AAD)]

[Article in Polish]

_Rokosz A_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Search & term= " Rokosz\

+A " [Author]) , _Sawicka-Grzelak A_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Search & term= " Sawick\

a-Grzelak+A " [Author]) ,

_Pituch H_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Search & term= " Pituch\

+H " [Author]) , _Luczak M_

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Search & term= " Luczak\

+M " [Author]) .

Katedra i Zaklad Mikrobiologii Lekarskiej AM w Warszawie.

The aim of performed examinations was to isolate, identify and determine a

drug susceptibility of fungi cultured from faecal specimens submitted for

detection of Clostridium difficile in cases of antibiotic-associated diarrhoea

(AAD). One hundred samples of diarrhoeic faeces were examined using routine

bacteriological methods (isolation and identification of C. difficile),

serological test (detection of C. difficile toxins A/B) and mycological methods

(isolation, identification and drug susceptibility testing of fungi). Out of

twenty seven specimens of diarrhoeic faeces fungal strains were isolated, in 20

samples C. difficile strain and/or C. difficile toxins A/B were detected, in 23

specimens fungal strains, C. difficile strains and/or toxins A/B of this

species were present. The most active in vitro agent against cultured fungal

strains was nystatin. In conclusion it can be stated, that fungal strains are

responsible for some cases of antibiotic-associated diarrhoea. So, mycological

diagnostics of faecal samples from patients with diarrhoea after antibiotic

therapy is necessary. Cases of diarrhoea with mixed bacterial and fungal

aetiology (C. difficile + yeast-like fungus) were observed.

PMID: 12650060 [PubMed - indexed for MEDLINE]