Re: Dr. Lipsey's Latest Literature Review -Stachybotrys/mycotoxins

[Guest guest]

Here are the latest scientific findings related to Stachybotrys/mycotoxin

exposure and human health effects.

(a work in progress )

Dr. L. Lipsey ( 904 )398-2168

550 Water St, #1230, ville, FL 32202

Forensic Toxicologist and Adjunct Instructor, Univ. N. Florida,

Div. Continuing Educ., HazMat/OSHA

Fla. Comm. College Jax, Institute of Occ. Safety & Health

Member Clinical Toxicology Advisory Committee, Florida Poison Information

Center- ville.

_www.richardlipsey.com_ (http://www.richardlipsey.com)

LATEST SCIENTIFIC ARTICLES

Dr. R. L. Lipsey Dec. 2005

1. Ochiai et al, 2005 Inhal. of Styachy can cause serious lung damage

in humans as the macrophage cells are killed (cytotoxic) and there is a strong

inflammatory response. It is not as toxic if injected into the lungs of mice.

2. Brasel...Straus, 2004 Tricothecene mycotoxins found in the blood in

23 humans exposed to Stachybotrys in indoor environments. Therefore,

airborne Styachy is inhaled with the mycotoxins attached to the spores and can

be

quantified with the ELISA method.

3. Crameri et al, 1996 A. fumigatus produced autoimmune disease,

allergic hypersensitivity responses, in humans.

4. Larsen et al, 1996 Tricoderma indoors produces histimine releases

in human bronchi and alveolar sacs.

5. Johanning et al, 1996 Stachybotrys in offices with water damage

produces brain damage or CNS effects in office workers that can be measured.

6. Etzel & Sorenson, 1998 Stachybotrys exposure is associated with

infant pulmonary hemorrhaging just like in the Cleveland, OH studies by CDC and

others.

7. Dales et al, 1991 Adverse health effects in humans in damp, moldy

buildings produces neurological disorders (CNS effects), dizziness, nausea,

mental fatigue and nosebleeds.

8. Croft...Jarvis et al, 1986 Moldy buildings produce an airborne

outbreak of tricothecene toxicosis.

9. Elidemir et al, 1999 Stachybotrys was isolated in the lungs of a

child suffering in the hospital with pulmonary hemosiderosis (PH) or chronic

bleeding in the lungs and coughing up blood. It can be fatal. If PH is

recurrent, it can cause interstitial fibrosis (Thrasher, 12/05 Stachybotrys

Lung

Effects).

10. Hodgson, Morey and Leung et al, 1998 Moldy buildings produces lung

damage in humans as the spores are inhaled. The pulmonary disease was caused

by Stachybotrys and Aspergillus versicolor.

11. Rao, 2000 & Feinberg et al, 1989 Tricothecenes from Stachybotrys in

indoor environments are strong inhibitors or protein synthesis.

12. Wannemacher et al, 1997 Tricothecenes from Stachybotrys and other

pathogenic molds are being researched by the US government as possible warfare

agents to kill the enemy.

13. Brasel.... et al, 2004 Airborne Stachybotrys mycotoxins

(tricothecenes) have been detected in the air on small particulates, not just

on

Stachybotrys spores in the air in moldy buildings. The levels of mycotoxins

in the air were low.

14. Sorenson.....Jarvis, 1987 Thicothecene mycotoxins from Stachybotrys

and other molds such as Fusarium have been detected in the air on aerolized

conidia.

15. Mason et al, 2001 and Rand et al, 2002 and Wilkins et al, 1998

Stachybotrys spores and their mycotoxins, ie tricothecenes in the air inside

lab

chambers destroy lung tissues and cause immune damage in laboratory animals

similar to the damage in humans, but a cause and effect or dose response

effect can be determined.

16. Vojani.....Thrasher, et al, 2002 Exposure to airborne Stachybotrys

and their mycotoxins produce adverse effects in humans and the levels of

exposure can be measured in the lab.

17. Vojani...., et al, 2002 Exposure by humans to pathogenic

molds in water damaged buildings can produce antibodies in the blood and

adverse

health effects.

18. ....Dearborn et al, 2004 Stachybotrys mycotoxins,

Satratoxin-G, was isolated in the lungs of mice exposed to Stachybotrys in the

lab.

19. Flemming.....Rand, 2004 The no adverse effect level, or NOAEL, for

exposure to Stachybotrys spores was less than 30 spores per gram of body

weight in lab mice following intratracheal exposure and a dose-response curve

could be determined and measured. However, the opportunistic allergen, more

commonly found in indoor moldy environments, was not as toxic as Stachybotrys

as

it was determined that the NOAEL was over 300 spores per gram of body

weight, or 10 times less toxic. Stachybotrys causes respiratory disease in lab

animals and humans.

[Guest guest]

What are the journal names? (or are they ALL indexed on Medline and

its obvious?)

Also.. another semi-technical question...

Does anyone know a way to detect trichothecene mycotoxins in dust or

paint? (I live in a building with a major mold (stachy/asp/pen)

problem and I want to document the mycotoxins, not just spores.)

BTW: Thank you!