May doxorubicin be a new alternative treatment agent for spasticity?A comparison of the effect of doxorubicin and phenol on the skeletal muscle

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J Pediatr Orthop B. 2005 Mar;14(2):134-8. Related Articles, Links

A comparison of the effect of doxorubicin and phenol on the skeletal muscle. May

doxorubicin be a new alternative treatment agent for spasticity?

Cullu E, Ozkan I, Culhaci N, Alparslan B.

aDepartment of Orthopaedics and Traumatology bDepartment of Pathology, Adnan

Menderes University, Medical School, Aydin, Turkey.

Since spasticity is still an unsolved problem for orthopaedic surgeons,

different chemical agents are tried before surgery. Phenol is a chemical agent

which has been used for spasticity treatment for a long time. Doxorubicin is an

antitumoral agent that has recently been used for chemomyectomy. The

intramuscular effects of phenol and two different dose of doxorubicin were

compared in that experimental study. In the first group 0.5 mg/0.5 cm

doxorubicin, in the second group 1 mg/0.5 doxorubicin and in the third group 5%

aqueous solution of fenol/0.5 injection were applied into left quadriceps muscle

of rats. Degeneration areas were wider in the high dose doxorubicin group

(29.9%; 8.5-61), in comparison with the low dose doxorubicin group (6.4%;

3.1-12) and phenol group (4%; 0-14) after 6 weeks. Differences in degeneration

area among three groups were statistically significant (P<0.001). The difference

was significant between the high dose doxorubicin group and the phenol group

(P=0.001) and also between the high dose doxorubicin group and the low dose

doxorubicin group (P<0.001). The results of this study suggested that

doxorubicin could provide an alternative treatment modality for neuromuscular

disease causing spasticity and it has a dose-dependent effect. Further studies

are needed for long-term comparison and clinical use of doxorubicin for

spasticity treatment.

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