Re: switching from Gleevec to Sprycell?

[Guest guest]

Does your Oncologist have any first hand experience with

switching?

He is pretty savvy and is a hematologist, he has and has had several CML

patients. I think he bringing this switch up to me, makes me feel he does have

my interest at heart. I just want to be sure I know all I can for that appt

in a few weeks.

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[Guest guest]

, those symptoms sounds so familiar, I have pain behind my left eye

brow right now. Just so weird, and I am over it! But, I always say, this

issues

are such a small price to pay.

We need to have a Aussie chat one day. I have not been in a few years, but

have so many friends in AU.

cheers,

chris

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[Guest guest]

Zavie, we have not gotten to a dosage at this time. We are just in the

talking phase, but he seems very sure he wants to do this. We will have an

appt

when the BCR comes back. Ok, off to the blood drawl.

chris

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[Guest guest]

Chris-

I switched from Gleevec 800mg to Sprycel 100mg last Deptember due to

intolerance to Gleevec. I responded well but the side effects left me with no

quality of life. I still have the fatigue and pain but its to a much lessor

degree. I have gain weight with Spyrcel but I did as well with Gleevec. I was

off

Gleevec for about 3 weeks (lost around 17 pounds) and have since put all

that back on. I think its retention.

I think you'll be happy with Sprycel. I have also not only tolerated it

better but I am responding well too. I am PCRU right now.

Don't get me wrong, I still have rough days mostly with the fatigue but I do

have quality again and that it what I needed.

Hugs and Hope-

36

CML 5/13/05

Gleevec 800mg until 8/07

Spyrcel 100 mg since 9/07

Wife and mother of 3 (12,9,7)

# 907 in Zavie's Zero Club

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[Guest guest]

Chris

A " wash-out " period is a good idea when switching to any drug. It

takes about 5 days for Gleevec to be removed from the body. This is

the amount of time that should occur before starting the new drug

A period of adjustment when switching to a new drug does seem to

occur. Does your Oncologist have any first hand experience with

switching?

[Guest guest]

Its very important to talk with your onc about the side effects when switching.

I had a pretty bad reaction but didn't have any time in between e.g. " washing

out " gleevec of my system. Others have made the switch pretty easily. I

eventually went back on gleevec and to my surprise, had many fewer systems. We

don't know why that happened. Hope it goes well.

Mararet

letitbe@... wrote:

Hello to everyone,

So looks like my Onc is most likely swapping my from Gleevec to Sprycell.

The plan here is to get me some relief as I still am having pretty bad head

pain and muscle fatigue. The Dr said after 15 months, we can genuinely call

this intolerance as it is not getting better and there are some definite

quality of life issues. This plan is not in concrete. I am going in this morning

for a PCR-ABL. Then he and I will get together when that comes back.

Just so I have my ducks in a row and seem like I know what I am talking

about =) Is there a sort of clean out Gleevec period, where I have no meds prior

to going on Sprycell or do I wake up one morning when the Gleevec is empty

and start right in on Sprycell?

I am all to familiar with the Gleevec side effects, what do I have to look

forward to with Sprycell?

Another concern, I am a sales rep, I am also the next few months in my prime

selling season. Would it be better to insist on waiting to start Sprycell

till after my prime season ends or is it safe to dive in, head first? I just

do not want to find myself with 4-6 weeks left to go in my season and be sick

as a dog, not able to work because I swapped into a new med. While I am

uncomfortable a good bit on Gleevec, I am functioning pretty darn well.

Thanks in advance for any thoughts. I remember several others switching

meds, like . I remember posting progress and that there were bumps in

the road. I guess this has got me pretty freaked out. Did not sleep at all

last night. I would dose off, but wake up thinking about this and am

nervous about my insurance going along, as the last I researched, Sprycell was a

good bit more money.

Thanks

Chris

**************Get trade secrets for amazing burgers. Watch " Cooking with

Tyler Florence " on AOL Food.

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[Guest guest]

G'day - I know what you mean about the headaches! I am trialling 200mg

Glivec at present due to my terrific response to Glivec. I don't know what

your PCR levels are, mine have gone from 13.01% at my first 3 month test, to

0.08% at my 6 month test. When I had a consult with Prof over here,

he believes the 400mg dose was toxic to me, so I had a 4 week break when I

felt fabulous to 7 days so far of 200mg. For 6 days no probs then had some

slight oedema in my eyelids and some burning pain across the top of my right

eye into the eyebrow and down beside my cheek bone. No fatigue so far - just

great! That lasted 2 days and OK again - so hopefully I can continue my

downward PCR trend, all be it a bit slower.

With my 4 week break, it took me 3 weeks to shake off the fluid retention,

headaches and fatigue.

In a weeks time I will have a serum blood level done to determine what the

level is and whether I have the 1000ng per ml required level. Have you had a

serum level done to check if your levels are too high? Prof said he

is finding that people are metabolizing it differently and perhaps this may

be why some of us are experiencing severe symptoms. Food for thought!

Regards,

Downunder

_____

From: [mailto: ] On Behalf Of

letitbe@...

Sent: Thursday, 22 May 2008 8:58 PM

Subject: [ ] switching from Gleevec to Sprycell?

Hello to everyone,

So looks like my Onc is most likely swapping my from Gleevec to Sprycell.

The plan here is to get me some relief as I still am having pretty bad head

pain and muscle fatigue. The Dr said after 15 months, we can genuinely call

this intolerance as it is not getting better and there are some definite

quality of life issues. This plan is not in concrete. I am going in this

morning

for a PCR-ABL. Then he and I will get together when that comes back.

Just so I have my ducks in a row and seem like I know what I am talking

about =) Is there a sort of clean out Gleevec period, where I have no meds

prior

to going on Sprycell or do I wake up one morning when the Gleevec is empty

and start right in on Sprycell?

I am all to familiar with the Gleevec side effects, what do I have to look

forward to with Sprycell?

Another concern, I am a sales rep, I am also the next few months in my prime

selling season. Would it be better to insist on waiting to start Sprycell

till after my prime season ends or is it safe to dive in, head first? I just

do not want to find myself with 4-6 weeks left to go in my season and be

sick

as a dog, not able to work because I swapped into a new med. While I am

uncomfortable a good bit on Gleevec, I am functioning pretty darn well.

Thanks in advance for any thoughts. I remember several others switching

meds, like . I remember posting progress and that there were bumps

in

the road. I guess this has got me pretty freaked out. Did not sleep at all

last night. I would dose off, but wake up thinking about this and am

nervous about my insurance going along, as the last I researched, Sprycell

was a

good bit more money.

Thanks

Chris

**************Get trade secrets for amazing burgers. Watch " Cooking with

Tyler Florence " on AOL Food.

(http://food.

<http://food.aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002>

aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002)

[Guest guest]

Hi

A wash out period is used by many doctors.

Have you any idea what dose of Sprycel you will be taking? Many doctors will

start you on a lower dose of Sprycel and ramp up until you reach the optimum

dose.

Good luck with the switch.

Zavie

Zavie (age 69)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.5 log reduction Jan/08

3.6 log reduction Apr/08

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

YM: zaviemiller

Skype: Zavie

_____

From: [mailto: ] On Behalf Of

letitbe@...

Sent: May 22, 2008 6:58 AM

Subject: [ ] switching from Gleevec to Sprycell?

Hello to everyone,

So looks like my Onc is most likely swapping my from Gleevec to Sprycell.

The plan here is to get me some relief as I still am having pretty bad head

pain and muscle fatigue. The Dr said after 15 months, we can genuinely call

this intolerance as it is not getting better and there are some definite

quality of life issues. This plan is not in concrete. I am going in this

morning

for a PCR-ABL. Then he and I will get together when that comes back.

Just so I have my ducks in a row and seem like I know what I am talking

about =) Is there a sort of clean out Gleevec period, where I have no meds

prior

to going on Sprycell or do I wake up one morning when the Gleevec is empty

and start right in on Sprycell?

I am all to familiar with the Gleevec side effects, what do I have to look

forward to with Sprycell?

Another concern, I am a sales rep, I am also the next few months in my prime

selling season. Would it be better to insist on waiting to start Sprycell

till after my prime season ends or is it safe to dive in, head first? I just

do not want to find myself with 4-6 weeks left to go in my season and be

sick

as a dog, not able to work because I swapped into a new med. While I am

uncomfortable a good bit on Gleevec, I am functioning pretty darn well.

Thanks in advance for any thoughts. I remember several others switching

meds, like . I remember posting progress and that there were bumps

in

the road. I guess this has got me pretty freaked out. Did not sleep at all

last night. I would dose off, but wake up thinking about this and am

nervous about my insurance going along, as the last I researched, Sprycell

was a

good bit more money.

Thanks

Chris

**************Get trade secrets for amazing burgers. Watch " Cooking with

Tyler Florence " on AOL Food.

(http://food.

<http://food.aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002>

aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002)

[Guest guest]

Yes it is fun (not). If 200mg glivec holds for me. I can certainly put up

with these symptoms.

What part of OZ did you visit?

Regards,

Down Under

_____

From: [mailto: ] On Behalf Of

letitbe@...

Sent: Thursday, 22 May 2008 10:37 PM

Subject: Re: [ ] switching from Gleevec to Sprycell?

, those symptoms sounds so familiar, I have pain behind my left eye

brow right now. Just so weird, and I am over it! But, I always say, this

issues

are such a small price to pay.

We need to have a Aussie chat one day. I have not been in a few years, but

have so many friends in AU.

cheers,

chris

**************Get trade secrets for amazing burgers. Watch " Cooking with

Tyler Florence " on AOL Food.

(http://food.

<http://food.aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002>

aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002)

[Guest guest]

Chris:

I switched to Sprycel three months ago and have no problems so far.

Effects vary from patient to patient. You can read up on the most common side

effects and potential problems on the website: www.sprycel.com

I had a 48 hour hiatus between stopping Gleevec and starting Sprycel.

Good luck with the transition.

Best wishes,

Carl

letitbe@... wrote:

Hello to everyone,

So looks like my Onc is most likely swapping my from Gleevec to Sprycell.

The plan here is to get me some relief as I still am having pretty bad head

pain and muscle fatigue. The Dr said after 15 months, we can genuinely call

this intolerance as it is not getting better and there are some definite

quality of life issues. This plan is not in concrete. I am going in this morning

for a PCR-ABL. Then he and I will get together when that comes back.

Just so I have my ducks in a row and seem like I know what I am talking

about =) Is there a sort of clean out Gleevec period, where I have no meds prior

to going on Sprycell or do I wake up one morning when the Gleevec is empty

and start right in on Sprycell?

I am all to familiar with the Gleevec side effects, what do I have to look

forward to with Sprycell?

Another concern, I am a sales rep, I am also the next few months in my prime

selling season. Would it be better to insist on waiting to start Sprycell

till after my prime season ends or is it safe to dive in, head first? I just

do not want to find myself with 4-6 weeks left to go in my season and be sick

as a dog, not able to work because I swapped into a new med. While I am

uncomfortable a good bit on Gleevec, I am functioning pretty darn well.

Thanks in advance for any thoughts. I remember several others switching

meds, like . I remember posting progress and that there were bumps in

the road. I guess this has got me pretty freaked out. Did not sleep at all

last night. I would dose off, but wake up thinking about this and am

nervous about my insurance going along, as the last I researched, Sprycell was a

good bit more money.

Thanks

Chris

**************Get trade secrets for amazing burgers. Watch " Cooking with

Tyler Florence " on AOL Food.

(http://food.aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002)

[Guest guest]

Hi

I switched from nilotinib to Dasatinib with no wash

out period, not sure why but Thursday Nilotinib Friday

Morning Dasatinib.. was a bad scene for about two

three days, but ok now... One of the warning is to

watch weight, water in lungs, pain in head itch etc

but it goes away. I had bad chills but they too went

away so I feel ok now..

SkipD

dx'ed 30++++ years ago

--- letitbe@... wrote:

> Hello to everyone,

>

> So looks like my Onc is most likely swapping my from

> Gleevec to Sprycell.

> The plan here is to get me some relief as I still am

> having pretty bad head

> pain and muscle fatigue. The Dr said after 15

> months, we can genuinely call

> this intolerance as it is not getting better and

> there are some definite

> quality of life issues. This plan is not in

> concrete. I am going in this morning

> for a PCR-ABL. Then he and I will get together

> when that comes back.

>

> Just so I have my ducks in a row and seem like I

> know what I am talking

> about =) Is there a sort of clean out Gleevec

> period, where I have no meds prior

> to going on Sprycell or do I wake up one morning

> when the Gleevec is empty

> and start right in on Sprycell?

>

> I am all to familiar with the Gleevec side effects,

> what do I have to look

> forward to with Sprycell?

>

> Another concern, I am a sales rep, I am also the

> next few months in my prime

> selling season. Would it be better to insist on

> waiting to start Sprycell

> till after my prime season ends or is it safe to

> dive in, head first? I just

> do not want to find myself with 4-6 weeks left to go

> in my season and be sick

> as a dog, not able to work because I swapped into a

> new med. While I am

> uncomfortable a good bit on Gleevec, I am

> functioning pretty darn well.

>

> Thanks in advance for any thoughts. I remember

> several others switching

> meds, like . I remember posting progress

> and that there were bumps in

> the road. I guess this has got me pretty freaked

> out. Did not sleep at all

> last night. I would dose off, but wake up thinking

> about this and am

> nervous about my insurance going along, as the last

> I researched, Sprycell was a

> good bit more money.

>

> Thanks

> Chris

>

>

>

> **************Get trade secrets for amazing burgers.

> Watch " Cooking with

> Tyler Florence " on AOL Food.

>

(http://food.aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002)

>

>

> [Non-text portions of this message have been

> removed]

>

>

[Guest guest]

,

I flew from Auckland to Melbourne, visited for a few weeks with mates, and

then to Brissy and a little south, I have very close family like group on the

Gold Coast, Mermaid Waters. I was supposed to be back in August and over

Father's Day weekend (AU that is), Labor Day for us. But, that has been

postponed. If everything falls into place, mid Feb next year. But, too early

to

tell on that.

Cheers,

Chris

**************Get trade secrets for amazing burgers. Watch " Cooking with

Tyler Florence " on AOL Food.

(http://food.aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002)

[Guest guest]

,

thanks for sharing your experience with me. I am a bit apprehensive on the

swap and this is my busy season, SO, I may ask that we postpone the change in

meds till later in August, once things settle a bit. I just do not want to

take any chances on disrupting what little is left of the weirdest selling

season I have ever had in 20 years.

chris

**************Get trade secrets for amazing burgers. Watch " Cooking with

Tyler Florence " on AOL Food.

(http://food.aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002)

[Guest guest]

Skip, thanks SO much for your perspective and experience. Now, I just hope

my insurance is like minded. It is probably a few weeks away before I see

the doc, and 19 June for sure as I have an appt set already. If I have learned

anything the last 15 months of CML in my life, knowingly - anyway, plan,

plan, plan and then prepare! lol

Cheers,

Chris

**************Get trade secrets for amazing burgers. Watch " Cooking with

Tyler Florence " on AOL Food.

(http://food.aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002)

[Guest guest]

Hi - we are way down south from Brisbane in . In my mind due

to heat and humidity, only nice time to visit there is late winter to spring

LOL. We did an outback trip as well which was great and went as high as

Rockhampton. Did you spend much time in NZ? I had 3 weeks there last year,

beautiful place.

Regards,

Down Under

_____

From: [mailto: ] On Behalf Of

letitbe@...

Sent: Friday, 23 May 2008 10:23 AM

Subject: Re: [ ] switching from Gleevec to Sprycell?

,

I flew from Auckland to Melbourne, visited for a few weeks with mates, and

then to Brissy and a little south, I have very close family like group on

the

Gold Coast, Mermaid Waters. I was supposed to be back in August and over

Father's Day weekend (AU that is), Labor Day for us. But, that has been

postponed. If everything falls into place, mid Feb next year. But, too early

to

tell on that.

Cheers,

Chris

**************Get trade secrets for amazing burgers. Watch " Cooking with

Tyler Florence " on AOL Food.

(http://food.

<http://food.aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002>

aol.com/tyler-florence?video=4 & ?NCID=aolfod00030000000002)