RE: Request for Clarification

[Guest guest]

Hi Morty,

Welcome to the group.

It's not at all unusual to bounce around from undetectable to

detectable. By most lab's standards, a result of 0.04 would be

considered a 3 log reduction so this is a very good result.

I would ask your doctor though, if both PCR's were done at the same

lab and what was the sensitivity of the tests. Regardless of the

answers though, I don't think you have anything to worry about. You

may well find that you continue to bounce in and out of PCRU.

Take care,

Tracey

dx Jan 2002

a fellow PCR bouncer

>

> I was diagnosed with CML last year in April. A PCR done in January

> came back negative, and another done in early March was O.04, my

Onc

> tells me. She says she isn't worried about the " step back " at this

> time. Does this have any long-term meaning? Should I be worred

that I

> went from negative to showing a low level?

>

> Thanks,

>

> Morty

>

[Guest guest]

Hi Mort,

I am a bouncer too. Don't worry. It's not unusual for me to fluctuate

in my pcr values. Be happy! And try not toworry! You're doing great!

Love, Genie

Also a fellow bouncer....dx'd 2/2000

> >

> > I was diagnosed with CML last year in April. A PCR done in

January

> > came back negative, and another done in early March was O.04, my

> Onc

> > tells me. She says she isn't worried about the " step back " at

this

> > time. Does this have any long-term meaning? Should I be worred

> that I

> > went from negative to showing a low level?

> >

> > Thanks,

> >

> > Morty

> >

>

[Guest guest]

O!!! YIPPEEE!!!

Number 1182 in the Zero Club

Zavie

Hi Morty,

Unfortunately it is the nature of the PCR test that can give these widely

varying results. Enjoy the number.

Zavie

Zavie (age 69)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.5 log reduction Jan/08

3.6 log reduction Apr/08

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

YM: zaviemiller

Skype: Zavie

_____

From: [mailto: ] On Behalf Of

mortycausa

Sent: May 21, 2008 11:12 PM

Subject: [ ] Request for Clarification

I was diagnosed with CML last year in April. A PCR done in January

came back negative, and another done in early March was O.04, my Onc

tells me. She says she isn't worried about the " step back " at this

time. Does this have any long-term meaning? Should I be worred that I

went from negative to showing a low level?

Thanks,

Morty

[Guest guest]

Hi, Morty.

I've had similar results -- a negative, followed by a slight positive,

followed by another negative, etc. Results can fluctuate like that

without causing concern. My doctor has advised me not to worry -- and

not to think about alternative therapies unless we see a clear trend

showing increases over several PCRs. You've had a great response --

PCRU in 9 months after diagnosis! If I were you, I wouldn't worry.

Did your doc schedule another follow-up PCR?

Warm wishes,

>

> I was diagnosed with CML last year in April. A PCR done in January

> came back negative, and another done in early March was O.04, my Onc

> tells me. She says she isn't worried about the " step back " at this

> time. Does this have any long-term meaning? Should I be worred that

I

> went from negative to showing a low level?

>

> Thanks,

>

> Morty

>