Re: RAD 001

[Guest guest]

Dear Lottie,

I might be a candidate for RAD001 someday but probably couldn't enter

the clinical trial because I can't pronounce its real name

(Everolimus).

Bob , Granger, Indiana

>

> While following some links, I found references to RAD 001 and

suddenly remembered it was the drug that my " little friend " , whom I

met at MDACC was taking for CML. Seems she was the only patient

enrolled in the trial.

> Now it seems they have found other uses for it. I found an

article about using it for the treatement of kidney cancer.

> " THE METHODIST group (in Houston) plans to enroll an additional

40 patients who have failed prior Nexavar or Sutent therapy. "

http://www.ackc.org/rad001. There is also a report from ASCO:

http://www.ackc.org/asco_2007

> " There are now four drugs that are FDA approved for kidney cancer:

Nexavar (2005), Sutent (2006), Torisel (2007), and Interleukin-2

(1992). There are also a couple of targeted agent drugs in the

pipeline that will likely be approved in 2008. It remains to be seen

if the availability of therapies will have an impact on the number of

patients who enter clinical trials, where new drugs are developed.

Currently only 3% of kidney cancer patients enter clinical trials. "

> It would seem that they are crossing over with RAD 001 in the

treatment of prostate cancer as well.

http://clinicaltrials.gov/show/NCT00630344. ' Orally administered

inhibitor of mTOR, is also being trialed in the treatment of

melonoma. ' Interim analysis after enrollment of 20 patients suggests

that RAD-001 is well tolerated and has sufficient anti-tumor activity

in MM to warrant the opening of enrollment to the second stage of

this trial. Further accrual is planned .Interim analysis after

enrollment of 20 patients suggests that RAD-001 is well tolerated and

has sufficient anti-tumor activity in MM to warrant the opening of

enrollment to the second stage of this trial. Further accrual is

planned. "

>

http://www.asco.org/portal/site/ASCO/menuitem.34d60f5624ba07fd506fe310

ee37a01d/?

vgnextoid=76f8201eb61a7010VgnVCM100000ed730ad1RCRD & vmview=abst_detail_

view & confID=40 & index=y & abstractID=30079

>

> Blessings and peace,

> Lottie