Re: Celebex

[Guest guest]

Thanks Lottie, I lost my Mom to heart disease at 46 yrs of age and all 4 of my

grandparents to strokes. I thought that I had read that the so called NSAID's

were not compatible with Gleevec . My onc left me for about 20 minutes and came

back and said she had researched it and that it was ok. Made me nervous that she

was saying it was ok but no experience with them. Thanks for your advice. God

Bless; Eva

From: Lottie Duthu

Sent: Friday, May 16, 2008 12:29 AM

CML

Subject: [ ] Celebex

Dear Eva,

I have never taken Celebrex, but I was on VIOXX and after having already had a

stroke, my doctor told me to stop taking it as it caused Strokes and heart

attacks,. Well he was too late in telling me, as I had already had the stroke,

and I then went on to have the heart attack. Some of us are more vunerable that

others, but I would keep tabs on it, like having a test to check for blockages

in your heart and your blood pressure. You can buy an inexpensive monitor and

keep a log. The 2 drugs are similiar as they were both NSAIDS.

Rofecoxib (Vioxx) was withdrawn from the U.S. market in 2004. Rofecoxib is in a

class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Rofecoxib

works by reducing substances that cause inflammation, pain, and fever in the

body. Rofecoxib is used to reduce pain, inflammation.

It is important to know that there are risks with all medicines, including the 3

most common prescription NSAIDs: CELEBREX, naproxen, and ibuprofen. In fact, the

FDA requires all prescription NSAID pain relievers, including CELEBREX, to have

the same cardiovascular warning.

Understanding the risks and benefits of different NSAIDs is important. All

NSAIDs, including CELEBREX, help relieve arthritis pain, but only you and your

doctor can decide which one is right for you. An NSAID like CELEBREX might be an

arthritis treatment option.

All prescription NSAIDs, including CELEBREX, have the same cardiovascular

warning: they may increase the chance of heart attack or stroke, which can lead

to death. The right pain relief for you will depend on many factors. These

include your history and the severity of your pain.

Eva, any drug you want to learn more about can be researched at

www.drugstore.com. That is where this information comes from. I also found this

about cox inhibitors.

The cyclooxygenase (COX) enzyme is actually present in two different forms,

COX-1 and COX-2, each with a similar but distinct set of actions. COX-2 is the

enzyme responsible for inflammation and fever, whereas COX-1 actually performs

other functions such as protecting the gastric mucosa (the lining of the

stomach) from the acid that the stomach naturally produces. COX-1 also plays a

role in making platelets stick together to form clots. Both reduce blood flow to

the kidneys, though. http://www.virtualmedicalcentre.com/treatments.asp?sid=78

After you are done reading all of this, maybe you could explain it to the rest

of us. LOL.

Blessings,

Lottie