RE: Nilotinib--Dasatinib..

[Guest guest]

Hi All,

What surprised me is that Nilotinib has a half life of 17 hours. You would

think that they would want the Nilotinib out of the system before

introducing a new drug.

Zavie

Zavie (age 69)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.5 log reduction Jan/08

3.6 log reduction Apr/08

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

YM: zaviemiller

Skype: Zavie

_____

From: [mailto: ] On Behalf Of Skip

Duffie

Sent: May 16, 2008 1:51 PM

; cmlhope

Subject: [ ] Nilotinib--Dasatinib..

Hello to all

I hope your all in excellent health.

I just finished talking to Zavie, and he said I should

post how things are going now that I am off

Nilotinib and on Dasatinib.. I am feeling very well

indeed but it was an experience switching.

I was on Nilotinib on Thursday of last week and

started Dasatinib on Friday, about 3AM I thought my

days fighting CML was over, I started shaking and had

the cills but no fever. For a few days I felt as if I

had just had a large meal, anything I ate would just

not go down. all of this only lasted about 2 to 3

days. I now feel fine, well, I needed last Monday

platelets again this Thursday I needed Platelets and

Red blood cells infusions. Now that I have had those

I am set for this weekend, which Monday is a holiday,

Medical Day gave me Monday off but I had to go in

Tuesday for tests... Zavie thought this would interest

you all.

be safe

SkipD

dx'ed 30++++ years ago

[Guest guest]

Hi Skip,

Thanks for the update. I'm glad you're feeling well. I agree with

Zavie that they should have given you a " wash out " period before

starting you on the Sprycel. I think most people who have switched

drugs have had at least a 5 day wash out period, some even longer.

Oh well, at least you're feeling well now, that's what matters.

Take care,

Tracey

>

> Hi All,

>

> What surprised me is that Nilotinib has a half life of 17 hours.

You would

> think that they would want the Nilotinib out of the system before

> introducing a new drug.

>

> Zavie

>

> Zavie (age 69)

> 67 Shoreham Avenue

> Ottawa, Canada, K2G 3X3

> dxd AUG/99

> INF OCT/99 to FEB/00, CHF

> No meds FEB/00 to JAN/01

> Gleevec since MAR/27/01 (400 mg)

> CCR SEP/01. #102 in Zero Club

> 2.8 log reduction Sep/05

> 3.0 log reduction Jan/06

> 2.9 log reduction Feb/07

> 3.5 log reduction Jan/08

> 3.6 log reduction Apr/08

> e-mail: zmiller@...

> Tel: 613-726-1117

> Fax: 309-296-0807

> Cell: 613-202-0204

> ID: zaviem

> YM: zaviemiller

> Skype: Zavie

>

> _____

>

> From: [mailto: ] On Behalf

Of Skip

> Duffie

> Sent: May 16, 2008 1:51 PM

> ; cmlhope

> Subject: [ ] Nilotinib--Dasatinib..

>

> Hello to all

> I hope your all in excellent health.

> I just finished talking to Zavie, and he said I should

> post how things are going now that I am off

> Nilotinib and on Dasatinib.. I am feeling very well

> indeed but it was an experience switching.

> I was on Nilotinib on Thursday of last week and

> started Dasatinib on Friday, about 3AM I thought my

> days fighting CML was over, I started shaking and had

> the cills but no fever. For a few days I felt as if I

> had just had a large meal, anything I ate would just

> not go down. all of this only lasted about 2 to 3

> days. I now feel fine, well, I needed last Monday

> platelets again this Thursday I needed Platelets and

> Red blood cells infusions. Now that I have had those

> I am set for this weekend, which Monday is a holiday,

> Medical Day gave me Monday off but I had to go in

> Tuesday for tests... Zavie thought this would interest

> you all.

> be safe

> SkipD

> dx'ed 30++++ years ago

>

>

>

>