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Re: Gleevec concern

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Hi Steph, so sorry your boy friend has cml, is he going to a cml expert? When

you take Gleevec you must take it with a substantial amount of food. Like a

large breakfast, maybe with some milk too. And he should not lie down directly

after taking it, this too can make him sick. It does take a while to get used

to this drug, it took me almost 2 months. I had nausea, headaches, pains in the

upper back and in general sometimes wanted to die.

Does he split his does? Like half in the morning and the other half in the

evening? Some

times, I would eat a bit, take a pill, eat some more and take another pill.

But he will get adapted to it it believe me. The yellow is something someone

else will have to answer. Br patient, this is a powerful drug and the body

takes time to adjust to it.

Good luck, Bobby

stephzour <stephzour@...> wrote:

Hi everybody.

My boyfriend has just started gleevec, it has been 2 days now. On his

second day on it (yesterday) he was experienceing nausea and vomited.

He also was very yellow yesterday. We are very concerned about his

turning yellow? Has anyone experienced this before. I have read that

it is a side effect, but not as common. I am also concerned that it

has only been 2 days and he already is reacting like this.

Thanks

Steph

a (Bobby) Doyle

Brecksville, Ohio, USA

DX 05/1995

02/2000 - Gleevec Trial/OHSU

06/2002 - Gleevec/Trisenox Trial/OHSU

06/2003 - Gleevec/Zarnestra Trial/OHSU

04/2004 - Sprycel Trial/MDACC, CCR in 10 months

#840 - Zavie's Zero Club

09/2006 - out of CCR

04/29/08 - XL228 Trial/ U.of Michigan

06/02/08 - CCR ( in 4 weeks)

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Steph,

The only thing I know of that would make someone yellow has something to do

with the liver. Like babies when they come home from the hospital they are

watch for jaundice .

Be sure to let your dr. know.

Sharon T

_____

From: [mailto: ] On Behalf Of

ROBERTA DOYLE

Sent: Saturday, June 21, 2008 8:52 AM

Subject: Re: [ ] Gleevec concern

Hi Steph, so sorry your boy friend has cml, is he going to a cml expert?

When you take Gleevec you must take it with a substantial amount of food.

Like a large breakfast, maybe with some milk too. And he should not lie down

directly after taking it, this too can make him sick. It does take a while

to get used to this drug, it took me almost 2 months. I had nausea,

headaches, pains in the upper back and in general sometimes wanted to die.

Does he split his does? Like half in the morning and the other half in the

evening? Some

times, I would eat a bit, take a pill, eat some more and take another pill.

But he will get adapted to it it believe me. The yellow is something someone

else will have to answer. Br patient, this is a powerful drug and the body

takes time to adjust to it.

Good luck, Bobby

stephzour <stephzour (DOT) <mailto:stephzour%40> com> wrote:

Hi everybody.

My boyfriend has just started gleevec, it has been 2 days now. On his

second day on it (yesterday) he was experienceing nausea and vomited.

He also was very yellow yesterday. We are very concerned about his

turning yellow? Has anyone experienced this before. I have read that

it is a side effect, but not as common. I am also concerned that it

has only been 2 days and he already is reacting like this.

Thanks

Steph

a (Bobby) Doyle

Brecksville, Ohio, USA

DX 05/1995

02/2000 - Gleevec Trial/OHSU

06/2002 - Gleevec/Trisenox Trial/OHSU

06/2003 - Gleevec/Zarnestra Trial/OHSU

04/2004 - Sprycel Trial/MDACC, CCR in 10 months

#840 - Zavie's Zero Club

09/2006 - out of CCR

04/29/08 - XL228 Trial/ U.of Michigan

06/02/08 - CCR ( in 4 weeks)

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Thanks Bobby. So far is he taking the whole pill at about 9pm. We

thought since fatigue might be an issue its better to take it at night

and he can go straight to sleep. But maybe we were wrong. I am not

sure if our doctor is a CML expert. We are going to in

Hamilton, Ontario. However I also pushed him to make an appointment

with Dr. Lipton in Toronto at Princess Margaret. From what I hear, he

is great, and definitely an expert.

Maybe breakfast is another time we should consider. Thanks for your input!

Steph

> Hi everybody.

> My boyfriend has just started gleevec, it has been 2 days now. On his

> second day on it (yesterday) he was experienceing nausea and vomited.

> He also was very yellow yesterday. We are very concerned about his

> turning yellow? Has anyone experienced this before. I have read that

> it is a side effect, but not as common. I am also concerned that it

> has only been 2 days and he already is reacting like this.

>

> Thanks

>

> Steph

>

>

>

>

>

>

> a (Bobby) Doyle

> Brecksville, Ohio, USA

> DX 05/1995

> 02/2000 - Gleevec Trial/OHSU

> 06/2002 - Gleevec/Trisenox Trial/OHSU

> 06/2003 - Gleevec/Zarnestra Trial/OHSU

> 04/2004 - Sprycel Trial/MDACC, CCR in 10 months

> #840 - Zavie's Zero Club

> 09/2006 - out of CCR

> 04/29/08 - XL228 Trial/ U.of Michigan

> 06/02/08 - CCR ( in 4 weeks)

>

>

>

>

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I think everyone finds their own 'time' to take Gleevec... I usually take

mine about 11:00 pm with a bowl of cereal. (Raisin Bran will NOT work. Fruit

loops, apple jacks okay. Cheerios with bananas - NOT okay. ) So, you'll have

to experiment with what foods work. Then, I go to bed about 11:30 or

midnight. After waiting 1/2 hour. I do NOT eat anything after I take the

pill, unless it is a bite or two to get it all the way down. Sometimes it

feels stuck. In the early days, I had to eat what felt like 1/2 a loaf of

bread in order not to feel sick. Journal what foods work and what don't...

you'll see a pattern. Steak and brocilli, though very filling, do not go

well with Gleevec. :)

I don't know about the yellow.

Good luck,

Tammy

_____

From: [mailto: ] On Behalf Of

stephzour

Sent: Saturday, June 21, 2008 10:53 AM

Subject: [ ] Gleevec concern

Hi everybody.

My boyfriend has just started gleevec, it has been 2 days now. On his

second day on it (yesterday) he was experienceing nausea and vomited.

He also was very yellow yesterday. We are very concerned about his

turning yellow? Has anyone experienced this before. I have read that

it is a side effect, but not as common. I am also concerned that it

has only been 2 days and he already is reacting like this.

Thanks

Steph

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Sharon, I have not been on Gleevec since 2004, and was on 600 mg. a day. I

took 3 and 3, as each capsule was 100 mg. What dose is your friend on? I would

think taking it at night would be ok, but does he eat a large meal before

bedtime? If you wait to long, and your stomach is empty you will get sick. Dr.

Lipton will have all your answers, and this group will help give you all your

questions, so be of good cheer, help is near! Bobby

stephzour <stephzour@...> wrote: Thanks Bobby. So far is he

taking the whole pill at about 9pm. We

thought since fatigue might be an issue its better to take it at night

and he can go straight to sleep. But maybe we were wrong. I am not

sure if our doctor is a CML expert. We are going to in

Hamilton, Ontario. However I also pushed him to make an appointment

with Dr. Lipton in Toronto at Princess Margaret. From what I hear, he

is great, and definitely an expert.

Maybe breakfast is another time we should consider. Thanks for your input!

Steph

> Hi everybody.

> My boyfriend has just started gleevec, it has been 2 days now. On his

> second day on it (yesterday) he was experienceing nausea and vomited.

> He also was very yellow yesterday. We are very concerned about his

> turning yellow? Has anyone experienced this before. I have read that

> it is a side effect, but not as common. I am also concerned that it

> has only been 2 days and he already is reacting like this.

>

> Thanks

>

> Steph

>

>

>

>

>

>

> a (Bobby) Doyle

> Brecksville, Ohio, USA

> DX 05/1995

> 02/2000 - Gleevec Trial/OHSU

> 06/2002 - Gleevec/Trisenox Trial/OHSU

> 06/2003 - Gleevec/Zarnestra Trial/OHSU

> 04/2004 - Sprycel Trial/MDACC, CCR in 10 months

> #840 - Zavie's Zero Club

> 09/2006 - out of CCR

> 04/29/08 - XL228 Trial/ U.of Michigan

> 06/02/08 - CCR ( in 4 weeks)

>

>

>

>

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Hi Bobby, that wasn't me---it is so easy to get mixed up on this site.

Sharon T

_____

From: [mailto: ] On Behalf Of

ROBERTA DOYLE

Sent: Saturday, June 21, 2008 10:03 AM

Subject: Re: [ ] Gleevec concern

Sharon, I have not been on Gleevec since 2004, and was on 600 mg. a day. I

took 3 and 3, as each capsule was 100 mg. What dose is your friend on? I

would think taking it at night would be ok, but does he eat a large meal

before bedtime? If you wait to long, and your stomach is empty you will get

sick. Dr. Lipton will have all your answers, and this group will help give

you all your questions, so be of good cheer, help is near! Bobby

stephzour <stephzour (DOT) <mailto:stephzour%40> com> wrote:

Thanks Bobby. So far is he taking the whole pill at about 9pm. We

thought since fatigue might be an issue its better to take it at night

and he can go straight to sleep. But maybe we were wrong. I am not

sure if our doctor is a CML expert. We are going to in

Hamilton, Ontario. However I also pushed him to make an appointment

with Dr. Lipton in Toronto at Princess Margaret. From what I hear, he

is great, and definitely an expert.

Maybe breakfast is another time we should consider. Thanks for your input!

Steph

> Hi everybody.

> My boyfriend has just started gleevec, it has been 2 days now. On his

> second day on it (yesterday) he was experienceing nausea and vomited.

> He also was very yellow yesterday. We are very concerned about his

> turning yellow? Has anyone experienced this before. I have read that

> it is a side effect, but not as common. I am also concerned that it

> has only been 2 days and he already is reacting like this.

>

> Thanks

>

> Steph

>

>

>

>

>

>

> a (Bobby) Doyle

> Brecksville, Ohio, USA

> DX 05/1995

> 02/2000 - Gleevec Trial/OHSU

> 06/2002 - Gleevec/Trisenox Trial/OHSU

> 06/2003 - Gleevec/Zarnestra Trial/OHSU

> 04/2004 - Sprycel Trial/MDACC, CCR in 10 months

> #840 - Zavie's Zero Club

> 09/2006 - out of CCR

> 04/29/08 - XL228 Trial/ U.of Michigan

> 06/02/08 - CCR ( in 4 weeks)

>

>

>

>

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Hi Steph,

The yellow color is a sign of liver toxicity (jaunisse). It may or may

not be serious but you should let your dr know quickly to have liver

enzymes tested. A significant minority of people are intolerant to

gleevec, what is ok now as there are other drugs that work as well as

gleevec and do not have this side effect. A few people on this list

had the same problem and are now doing fine on Sprycel or Tasigna.

Marcos.

On Sat, Jun 21, 2008 at 7:52 AM, stephzour <stephzour@...> wrote:

> Hi everybody.

> My boyfriend has just started gleevec, it has been 2 days now. On his

> second day on it (yesterday) he was experienceing nausea and vomited.

> He also was very yellow yesterday. We are very concerned about his

> turning yellow? Has anyone experienced this before. I have read that

> it is a side effect, but not as common. I am also concerned that it

> has only been 2 days and he already is reacting like this.

>

> Thanks

>

> Steph

>

>

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 614 2305

650 630 5015 (cell)

marcospg@...

montereyunderwater@...

www.stanford.edu/~marcospg/

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RIGHT, THAT WAS STEPH, THANKS, IT was STEPH, WASN'T IT ????

Sharon & Denny <onthewtr@...> wrote: Hi Bobby, that wasn't

me---it is so easy to get mixed up on this site.

Sharon T

_____

From: [mailto: ] On Behalf Of

ROBERTA DOYLE

Sent: Saturday, June 21, 2008 10:03 AM

Subject: Re: [ ] Gleevec concern

Sharon, I have not been on Gleevec since 2004, and was on 600 mg. a day. I

took 3 and 3, as each capsule was 100 mg. What dose is your friend on? I

would think taking it at night would be ok, but does he eat a large meal

before bedtime? If you wait to long, and your stomach is empty you will get

sick. Dr. Lipton will have all your answers, and this group will help give

you all your questions, so be of good cheer, help is near! Bobby

stephzour <stephzour (DOT) <mailto:stephzour%40> com> wrote:

Thanks Bobby. So far is he taking the whole pill at about 9pm. We

thought since fatigue might be an issue its better to take it at night

and he can go straight to sleep. But maybe we were wrong. I am not

sure if our doctor is a CML expert. We are going to in

Hamilton, Ontario. However I also pushed him to make an appointment

with Dr. Lipton in Toronto at Princess Margaret. From what I hear, he

is great, and definitely an expert.

Maybe breakfast is another time we should consider. Thanks for your input!

Steph

> Hi everybody.

> My boyfriend has just started gleevec, it has been 2 days now. On his

> second day on it (yesterday) he was experienceing nausea and vomited.

> He also was very yellow yesterday. We are very concerned about his

> turning yellow? Has anyone experienced this before. I have read that

> it is a side effect, but not as common. I am also concerned that it

> has only been 2 days and he already is reacting like this.

>

> Thanks

>

> Steph

>

>

>

>

>

>

> a (Bobby) Doyle

> Brecksville, Ohio, USA

> DX 05/1995

> 02/2000 - Gleevec Trial/OHSU

> 06/2002 - Gleevec/Trisenox Trial/OHSU

> 06/2003 - Gleevec/Zarnestra Trial/OHSU

> 04/2004 - Sprycel Trial/MDACC, CCR in 10 months

> #840 - Zavie's Zero Club

> 09/2006 - out of CCR

> 04/29/08 - XL228 Trial/ U.of Michigan

> 06/02/08 - CCR ( in 4 weeks)

>

>

>

>

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Bobby, what are you on now since you have stopped Gleevec in 2004?

Steph

> > Hi everybody.

> > My boyfriend has just started gleevec, it has been 2 days now. On his

> > second day on it (yesterday) he was experienceing nausea and vomited.

> > He also was very yellow yesterday. We are very concerned about his

> > turning yellow? Has anyone experienced this before. I have read that

> > it is a side effect, but not as common. I am also concerned that it

> > has only been 2 days and he already is reacting like this.

> >

> > Thanks

> >

> > Steph

> >

> >

> >

> >

> >

> >

> > a (Bobby) Doyle

> > Brecksville, Ohio, USA

> > DX 05/1995

> > 02/2000 - Gleevec Trial/OHSU

> > 06/2002 - Gleevec/Trisenox Trial/OHSU

> > 06/2003 - Gleevec/Zarnestra Trial/OHSU

> > 04/2004 - Sprycel Trial/MDACC, CCR in 10 months

> > #840 - Zavie's Zero Club

> > 09/2006 - out of CCR

> > 04/29/08 - XL228 Trial/ U.of Michigan

> > 06/02/08 - CCR ( in 4 weeks)

> >

> >

> >

> >

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Dear Steph, I was one of the ones who suffered from high liver enzymes. I guess

it's possible to turn yellow after 2 doses of gleevec but, I really think it

would take longer. What else has he been taking? Is he drinking alcohol or

taking tylenol? These probably should be avoided until he finds out how he will

tolerate the gleevec. I really didn't turn too yellow but I had horrible itching

and that is what sent me to the ER. He really should be checked out by a doctor.

If it is the gleevec, there are ways of making the body accept it. Lynn F.

[ ] Gleevec concern

Hi everybody.

My boyfriend has just started gleevec, it has been 2 days now. On his

second day on it (yesterday) he was experienceing nausea and vomited.

He also was very yellow yesterday. We are very concerned about his

turning yellow? Has anyone experienced this before. I have read that

it is a side effect, but not as common. I am also concerned that it

has only been 2 days and he already is reacting like this.

Thanks

Steph

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Steph,if you look at the signature at the bottom, it will tell you ALL the

trials I have been in and the drugs. I am now on a new one, it's an infusion,

once a week in Ann Arbor MI, and it's known as XL228, have NO idea what it is.

Except after 3 infusions I am back in CCR, or complete cytogenetic remission. It

is not without it's complications, I am anemic, and now I am neutropenic. Low

blood counts, and low neutrifils, and will get a transfusion Mon.

It all sounds real bad, but I feel pretty good and after the transfusion will

feel much better.

There are lots of things out there now, so if Gleevec is not the answer,

there are other ways to go, and the appointment with Dr. Lipton will put you at

ease, I am sure, Good luck, Bobby

ps, if you dont mind, it would be easier to say a name, rather than , your boy

friend, so do you think you could tell us his name? Also, it's much nicer to

say a name in a prayer rather than Steph's boy friend!! If I missed it, sorry,

I am very forgetful....

stephzour <stephzour@...> wrote:

Bobby, what are you on now since you have stopped Gleevec in 2004?

Steph

> > Hi everybody.

> > My boyfriend has just started gleevec, it has been 2 days now. On his

> > second day on it (yesterday) he was experienceing nausea and vomited.

> > He also was very yellow yesterday. We are very concerned about his

> > turning yellow? Has anyone experienced this before. I have read that

> > it is a side effect, but not as common. I am also concerned that it

> > has only been 2 days and he already is reacting like this.

> >

> > Thanks

> >

> > Steph

> >

> >

> >

> >

> >

> >

> > a (Bobby) Doyle

> > Brecksville, Ohio, USA

> > DX 05/1995

> > 02/2000 - Gleevec Trial/OHSU

> > 06/2002 - Gleevec/Trisenox Trial/OHSU

> > 06/2003 - Gleevec/Zarnestra Trial/OHSU

> > 04/2004 - Sprycel Trial/MDACC, CCR in 10 months

> > #840 - Zavie's Zero Club

> > 09/2006 - out of CCR

> > 04/29/08 - XL228 Trial/ U.of Michigan

> > 06/02/08 - CCR ( in 4 weeks)

> >

> >

> >

> >

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So sorry, my bad. His name is .

Thanks for your prayers.

Everyone on here is soo supportive and reassuing. Thank you soo much!

Steph

> > > Hi everybody.

> > > My boyfriend has just started gleevec, it has been 2 days now.

On his

> > > second day on it (yesterday) he was experienceing nausea and

vomited.

> > > He also was very yellow yesterday. We are very concerned about his

> > > turning yellow? Has anyone experienced this before. I have read that

> > > it is a side effect, but not as common. I am also concerned that it

> > > has only been 2 days and he already is reacting like this.

> > >

> > > Thanks

> > >

> > > Steph

> > >

> > >

> > >

> > >

> > >

> > >

> > > a (Bobby) Doyle

> > > Brecksville, Ohio, USA

> > > DX 05/1995

> > > 02/2000 - Gleevec Trial/OHSU

> > > 06/2002 - Gleevec/Trisenox Trial/OHSU

> > > 06/2003 - Gleevec/Zarnestra Trial/OHSU

> > > 04/2004 - Sprycel Trial/MDACC, CCR in 10 months

> > > #840 - Zavie's Zero Club

> > > 09/2006 - out of CCR

> > > 04/29/08 - XL228 Trial/ U.of Michigan

> > > 06/02/08 - CCR ( in 4 weeks)

> > >

> > >

> > >

> > >

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Thanks Lynn.

He hasn't been drinking alcohol, nor did he take any tylenol. He was

on Hydrea for a month prior to his Gleevec. Today his color looked

ok. We have an appointment with the doctor in 2 weeks, but I am

thinking we may have to make it sooner.

SO what meds are you on now, if you don't mind me asking.

Take care Lynn,

Steph

>

> Dear Steph, I was one of the ones who suffered from high liver

enzymes. I guess it's possible to turn yellow after 2 doses of gleevec

but, I really think it would take longer. What else has he been

taking? Is he drinking alcohol or taking tylenol? These probably

should be avoided until he finds out how he will tolerate the

gleevec. I really didn't turn too yellow but I had horrible itching

and that is what sent me to the ER. He really should be checked out by

a doctor. If it is the gleevec, there are ways of making the body

accept it. Lynn F.

> [ ] Gleevec concern

>

>

> Hi everybody.

> My boyfriend has just started gleevec, it has been 2 days now. On his

> second day on it (yesterday) he was experienceing nausea and vomited.

> He also was very yellow yesterday. We are very concerned about his

> turning yellow? Has anyone experienced this before. I have read that

> it is a side effect, but not as common. I am also concerned that it

> has only been 2 days and he already is reacting like this.

>

> Thanks

>

> Steph

>

>

>

>

>

>

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Steph

Yellow - Have no idea - is that like a jaundice colour -.Jaundice is a liver

issue.

I don't ever recall turning yellow as glivec side effect.

I would suggest you contact your specialist asap

Bobby has given you good advise

You must eat stodgy food - not salads etc with glivec - you need carbohydrates,

something for the

chemicals to hold onto. You also must be hydrated.

Be up and about before you have your meal and as suggested do not go and lay or

sit down - you need

to move about.

Try different times of eating (some people have lunch, dinner, early meals -

etc)

I have mine at breakfast with 2 pieces of toast with jam -

I take 600mg so I take 600ml of water

I no longer take any milk fats with glivec

Milk, yoghurt etc was making me queesy.

After taking breakfast, glivec, water I then go for a walk.

I only have hot chocolate with milk and any milk products in the afternoon .

The yellow colour is an issue that must be sorted as soon as possible - could be

another medical problem.

Nothing worse than feeling queezy

Sue

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No Steph you are not bad, you just have to much on your mind, and many people

do not want their name used, I'm sure when we pray for " Sephp's boyfriend " , the

Lord knows it's . Have a great day.

stephzour <stephzour@...> wrote: So sorry, my bad. His name is

.

Thanks for your prayers.

Everyone on here is soo supportive and reassuing. Thank you soo much!

Steph

> > > Hi everybody.

> > > My boyfriend has just started gleevec, it has been 2 days now.

On his

> > > second day on it (yesterday) he was experienceing nausea and

vomited.

> > > He also was very yellow yesterday. We are very concerned about his

> > > turning yellow? Has anyone experienced this before. I have read that

> > > it is a side effect, but not as common. I am also concerned that it

> > > has only been 2 days and he already is reacting like this.

> > >

> > > Thanks

> > >

> > > Steph

> > >

> > >

> > >

> > >

> > >

> > >

> > > a (Bobby) Doyle

> > > Brecksville, Ohio, USA

> > > DX 05/1995

> > > 02/2000 - Gleevec Trial/OHSU

> > > 06/2002 - Gleevec/Trisenox Trial/OHSU

> > > 06/2003 - Gleevec/Zarnestra Trial/OHSU

> > > 04/2004 - Sprycel Trial/MDACC, CCR in 10 months

> > > #840 - Zavie's Zero Club

> > > 09/2006 - out of CCR

> > > 04/29/08 - XL228 Trial/ U.of Michigan

> > > 06/02/08 - CCR ( in 4 weeks)

> > >

> > >

> > >

> > >

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Steph, I am only on gleevec now. When my liver was acting up, I was on

prednisone, also. That was almost 5 years ago. Lynn

[ ] Gleevec concern

>

>

> Hi everybody.

> My boyfriend has just started gleevec, it has been 2 days now. On his

> second day on it (yesterday) he was experienceing nausea and vomited.

> He also was very yellow yesterday. We are very concerned about his

> turning yellow? Has anyone experienced this before. I have read that

> it is a side effect, but not as common. I am also concerned that it

> has only been 2 days and he already is reacting like this.

>

> Thanks

>

> Steph

>

>

>

>

>

>

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Steph,

My doctor said take it with largest meal of the day--about halfway

through the meal--so you have some food, take your Gleevec, then

have some more food--it sort of protects your stomach. Also, take

an acid blocker--Prevacid or something similar--that really helped

me feel better. The yellow skin is definitively something to talk to

the doctor about. Could be jaundice. I have had vomiting too--but

only when I neglected the taking with food part. That is very

important. Good luck. Let us know how it goes.

Vicki Schepman

> > Hi everybody.

> > My boyfriend has just started gleevec, it has been 2 days now.

On his

> > second day on it (yesterday) he was experienceing nausea and

vomited.

> > He also was very yellow yesterday. We are very concerned about

his

> > turning yellow? Has anyone experienced this before. I have read

that

> > it is a side effect, but not as common. I am also concerned that

it

> > has only been 2 days and he already is reacting like this.

> >

> > Thanks

> >

> > Steph

> >

> >

> >

> >

> >

> >

> > a (Bobby) Doyle

> > Brecksville, Ohio, USA

> > DX 05/1995

> > 02/2000 - Gleevec Trial/OHSU

> > 06/2002 - Gleevec/Trisenox Trial/OHSU

> > 06/2003 - Gleevec/Zarnestra Trial/OHSU

> > 04/2004 - Sprycel Trial/MDACC, CCR in 10 months

> > #840 - Zavie's Zero Club

> > 09/2006 - out of CCR

> > 04/29/08 - XL228 Trial/ U.of Michigan

> > 06/02/08 - CCR ( in 4 weeks)

> >

> >

> >

> >

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