Tasigna

June 28, 2008

The targeted agent Tasigna® (nilotinib) appears to be an effective treatment for

patients with newly diagnosed chronic myeloid leukemia (CML). These results were

recently presented at the 2008 annual meeting of the American Society of

Clinical Oncology. http://www.caring4cancer.com/go/cancer/news?NewsItemId=42213

Visit this website.

Sprycel effective for new patients with CML.

http://www.caring4cancer.com/go/Cancer/news?NewsItemId=42221

__________________________________________________________________________

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Lilly Oncology presents the 2008 Lilly Oncology on Canvas Art Competition and

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http://www.lillyoncologyoncanvas.com/2008_contest/index.jsp?WT.mc_id=LOOC_2008 & D\

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Should you require guidance and information, please call or e-mail the art

competition director, Anita Chernewski:

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Blessings,

Lottie

August 6, 2008

:

If I eat and then take Tasigna, then I feel

as if my body is struggling to process it,

if that makes sense. I can just tell that

I am not feeling right and it takes some

time to get rid of that feeling.

Yes, QT Prolongation is the biggest

concern and that is why you need

weekly EKG's done for your first

month on the drug.

Over time, you body will adjust and

you will be better than ever. Just

wait, you will see.

Matt

In a message dated 8/6/2008 8:53:54 A.M. Eastern Daylight Time,

rodorbal@... writes:

Hi Matt - thanks for the info, it is always good to get it first hand so to

speak. I know that if you have food with Tasigna is a definite no no due to

as you say, taking with food increases the absorption. I have a large glass

of water with the capsule, so at least have a drink after 2 hours fasting.

It's interesting with Glivec, that I never had a problem drinking alcohol

with it and with Tasigna have only had 1 glass of wine so far, as with the

cold I haven't felt like anything much. I hate grapefruit and it's juice, so

no problem and never taken St s Wart. My haem't passed on all the info

that Novartis sent him re contra indications, possible adverse effects etc

as I am his first patient on Tasigna, so we will be learning together. It's

great to have " thin " ankles again and eyes I can see out of! I was doing

well on Glivec 200mg, but as I have only just had my first CML anniversary,

it was felt it was too risky to continue on at this stage and I also had a

low serum level.

I am still taking my magnesium tablets as I know this can also be a problem

with Tasigna. I have been on this drug 10 days now and it is a joy compared

to Glivec and I have been able to stop taking diuretics and other medication

I was taking for the migraines I was experiencing.

Dr Tim our leading CML specialist told me that if you were to eat a

fatty meal without fasting on Tasigna, that possible side effects could

affect the heart (QT prolongation)affect the heart (QT prolongation)<WB

experience issues with pancreas and rises in serum amylase, lipase etc. I

had a base line ECG and that was fine and my haem't is monitoring that

closely.

When you say " I can tell if I eat and then take Tasigna that it is more

potent, but not as much afterward " , what sort of side effects do you get?

Regards,

from Downunder

From: _@..._ (mailto: )

[mailto:_@..._ (mailto: ) ] On Behalf Of

_mtmaynor@..._ (mailto:mtmaynor@...)

Sent: Wednesday, 6 August 2008 10:09 PM

_@..._ (mailto: )

Subject: Re: [ ] tasigna

:

Regarding your Tasigna question.

According to my oncologist, they want you to have an

empty stomach, so liquids or solids are supposed to

be kept to a minimum. It has to do with the absorption

and efficacy in your system, from what I understand. A

full stomach increases the potency and thus can trigger

heart or organ issues. For me, it seems that the no food

two hours before is the most important. I can tell if I eat

and then take Tasigna that it is more potent, but not as

much afterward. Just like Gleevec, you will find the things

that work and do not work for you. The standard things to

watch on Gleevec, you also need to watch on Tasigna

including Tylenol, St. s Wart and Grapefruit Juice, to

name just a few.

A lot of people find, especially after loose stools from

Gleevec, that they have constipation (a shock to your

system, especially if you have been on Gleevec for

several years) so I take my doses with a half of a glass

of Metamucil and I have no problems. Another thing to

watch out for is middle back pain. This may be a sign

of high Lipase, which is a concern of toxicity in your

pancreas, which I experienced early on as I made the

adjustment. You should call your Oncologist if this occurs.

One thing that I found on Tasigna was that I could drink,

which I really could not on Gleevec. So maybe you have

that to look forward to.

I hope Tasigna works well for you.

Matt

Florida CML Army

Zero Club Number Misplaced

In a message dated 8/6/2008 4:55:44 A.M. Eastern Daylight Time,

_rodorbal@..._ (mailto:rodorbal@...)

<mailto:rodorbal%mailto:rodmailto> writes:

Hi everyone,

I commenced Tasigna last week - 400mg once a day and will commence 200mg

tonight, working my way up to 400mg. After the very unlovely side effects of

Glivec, I am hesitant about going up to " full " strength without a lead in

and my haem/t has been very supportive of this.

So far I have tolerated 400mg with no problems, except that I have the worse

head cold I have had in years, which was developing before I started taking

Tasigna.

Just a question for the more experienced - when fasting at night, can you

still have water? I hate to think what it will be like come summer if I

can't have any water for 3 hours!

I was going to start last night, then forgot to take the capsule at 7pm, so

as we had family around to celebrate my daughter's birthday, I didn't take

it last night. I can see I am going to need to be very disciplined, which I

am not as I would often forget to take my Glivec at teatime and take later

in the night.

Regards,

from Down Under

Rodorbal Labradors Australia

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August 6, 2008

You are welcome, but hopefully others

who have more experience than I am will

way in as well.

My first dose is when I get up in the morning

so my stomach is very empty then, it is the

second dose that is always tricky. I am

usually working, so I do not have a chance

to snack in the afternoon, so my second

dose is usually around five, which puts me

at least an hour before dinner.

While it is not a problem waiting an hour

to eat, sometimes I find I do need to eat

at the one hour point, or I start to feel bad,

but it may not be that way for you. Usually

five or six saltines, or Wheat Things (my

choice) are good.

Matt

In a message dated 8/6/2008 9:38:04 A.M. Eastern Daylight Time,

rodorbal@... writes:

Thanks Matt. I'll just keep crossing my fingers that no side effects pop up!

Regards,

from Down Under

From: _@..._ (mailto: )

[mailto:_@..._ (mailto: ) ] On Behalf Of

_mtmaynor@..._ (mailto:mtmaynor@...)

Sent: Wednesday, 6 August 2008 11:22 PM