RAD 001

[Guest guest]

While following some links, I found references to RAD 001 and suddenly

remembered it was the drug that my " little friend " , whom I met at MDACC was

taking for CML. Seems she was the only patient enrolled in the trial.

Now it seems they have found other uses for it. I found an article about

using it for the treatement of kidney cancer.

" THE METHODIST group (in Houston) plans to enroll an additional 40 patients

who have failed prior Nexavar or Sutent therapy. " http://www.ackc.org/rad001.

There is also a report from ASCO: http://www.ackc.org/asco_2007

" There are now four drugs that are FDA approved for kidney cancer: Nexavar

(2005), Sutent (2006), Torisel (2007), and Interleukin-2 (1992). There are also

a couple of targeted agent drugs in the pipeline that will likely be approved in

2008. It remains to be seen if the availability of therapies will have an impact

on the number of patients who enter clinical trials, where new drugs are

developed. Currently only 3% of kidney cancer patients enter clinical trials. "

It would seem that they are crossing over with RAD 001 in the treatment of

prostate cancer as well. http://clinicaltrials.gov/show/NCT00630344. ' Orally

administered inhibitor of mTOR, is also being trialed in the treatment of

melonoma. ' Interim analysis after enrollment of 20 patients suggests that

RAD-001 is well tolerated and has sufficient anti-tumor activity in MM to

warrant the opening of enrollment to the second stage of this trial. Further

accrual is planned .Interim analysis after enrollment of 20 patients suggests

that RAD-001 is well tolerated and has sufficient anti-tumor activity in MM to

warrant the opening of enrollment to the second stage of this trial. Further

accrual is planned. "

http://www.asco.org/portal/site/ASCO/menuitem.34d60f5624ba07fd506fe310ee37a01d/?\

vgnextoid=76f8201eb61a7010VgnVCM100000ed730ad1RCRD & vmview=abst_detail_view & confI\

D=40 & index=y & abstractID=30079

Blessings and peace,

Lottie