Guest guest Posted August 6, 2008 Report Share Posted August 6, 2008 I have been on 400 mg since January. I take both tablets ( 200 each) in the morning soon as I wake. I find that my stomach is most empty then, and by the time I get up, shower, ready for work, then an hour has passed and I can have the coffee and breakfast without any hesitation. It really works for me. Like Matt, can have a glass of wine on tasigna. We do want to watch the AST/ALT counts for liver because tasigna tends to run them high and the wine or alcolol wouldn't help with that! I also find I can be in the sun a little without burning, and I have a healthy look now rather than the gleevec transparent skin! In all, I think you will find this drug to be THE best solution all the way around. I am absolutelyelated on it. Be well, Barb Barb Stanley 57 DX 5-5-2002 age 51 Hydroxurea 5-5-02-6-3--02 Gleevec 400 mg 6-11-02 MMR 8-1-02 CCR 12-10-02 PCRU 3-17-03 Gleevec break: Feb. 15 - May 1-2007 (severe side effects) Gleevec 300 mg. May 1 - Dec. 15- 2007 800 mg tasigna Dec. 27 -Jan 12 ( stopped because of side effects) 400 mg tasigna Jan 20 - present (NO SIDE EFFECTS) Continuing strong PCRU > > Thanks Matt. I'll just keep crossing my fingers that no side effects pop up! > > > > > Regards, > > > > from Down Under > > > > > > From: [mailto: ] On Behalf Of > mtmaynor@... > Sent: Wednesday, 6 August 2008 11:22 PM > > Subject: Re: [ ] tasigna > > > > : > > If I eat and then take Tasigna, then I feel > as if my body is struggling to process it, > if that makes sense. I can just tell that > I am not feeling right and it takes some > time to get rid of that feeling. > > Yes, QT Prolongation is the biggest > concern and that is why you need > weekly EKG's done for your first > month on the drug. > > Over time, you body will adjust and > you will be better than ever. Just > wait, you will see. > > Matt > > > > > > In a message dated 8/6/2008 8:53:54 A.M. Eastern Daylight Time, > rodorbal@... <mailto:rodorbal%40westvic.com.au> writes: > > Hi Matt - thanks for the info, it is always good to get it first hand so to > speak. I know that if you have food with Tasigna is a definite no no due to > as you say, taking with food increases the absorption. I have a large glass > of water with the capsule, so at least have a drink after 2 hours fasting. > > It's interesting with Glivec, that I never had a problem drinking alcohol > with it and with Tasigna have only had 1 glass of wine so far, as with the > cold I haven't felt like anything much. I hate grapefruit and it's juice, so > no problem and never taken St s Wart. My haem't passed on all the info > that Novartis sent him re contra indications, possible adverse effects etc > as I am his first patient on Tasigna, so we will be learning together. It's > great to have " thin " ankles again and eyes I can see out of! I was doing > well on Glivec 200mg, but as I have only just had my first CML anniversary, > it was felt it was too risky to continue on at this stage and I also had a > low serum level. > > I am still taking my magnesium tablets as I know this can also be a problem > with Tasigna. I have been on this drug 10 days now and it is a joy compared > to Glivec and I have been able to stop taking diuretics and other medication > I was taking for the migraines I was experiencing. > > Dr Tim our leading CML specialist told me that if you were to eat a > fatty meal without fasting on Tasigna, that possible side effects could > affect the heart (QT prolongation)affect the heart (QT prolongation)<WB > experience issues with pancreas and rises in serum amylase, lipase etc. I > had a base line ECG and that was fine and my haem't is monitoring that > closely. > > When you say " I can tell if I eat and then take Tasigna that it is more > potent, but not as much afterward " , what sort of side effects do you get? > > Regards, > > from Downunder > > From: _@... <mailto:_%40groups.CML> _ > (mailto: <mailto:%40> ) > [mailto:_@... <mailto:_%40groups.CML> _ > (mailto: <mailto:%40> ) ] On Behalf > Of > _mtmaynor@... <mailto:_mtmaynor%40aol.mtm> _ (mailto:mtmaynor@... > <mailto:mtmaynor%40aol.com> ) > Sent: Wednesday, 6 August 2008 10:09 PM > _@... <mailto:_%40groups.CML> _ > (mailto: <mailto:%40> ) > Subject: Re: [ ] tasigna > > : > > Regarding your Tasigna question. > > According to my oncologist, they want you to have an > empty stomach, so liquids or solids are supposed to > be kept to a minimum. It has to do with the absorption > and efficacy in your system, from what I understand. A > full stomach increases the potency and thus can trigger > heart or organ issues. For me, it seems that the no food > two hours before is the most important. I can tell if I eat > and then take Tasigna that it is more potent, but not as > much afterward. Just like Gleevec, you will find the things > that work and do not work for you. The standard things to > watch on Gleevec, you also need to watch on Tasigna > including Tylenol, St. s Wart and Grapefruit Juice, to > name just a few. > > A lot of people find, especially after loose stools from > Gleevec, that they have constipation (a shock to your > system, especially if you have been on Gleevec for > several years) so I take my doses with a half of a glass > of Metamucil and I have no problems. Another thing to > watch out for is middle back pain. This may be a sign > of high Lipase, which is a concern of toxicity in your > pancreas, which I experienced early on as I made the > adjustment. You should call your Oncologist if this occurs. > > One thing that I found on Tasigna was that I could drink, > which I really could not on Gleevec. So maybe you have > that to look forward to. > > I hope Tasigna works well for you. > > Matt > Florida CML Army > Zero Club Number Misplaced > > In a message dated 8/6/2008 4:55:44 A.M. Eastern Daylight Time, > _rodorbal@... <mailto:_rodorbal%40westvic.rodorb> _ > (mailto:rodorbal@... <mailto:rodorbal%40westvic.com.au> ) > <mailto:rodorbal%mailto:rodmailto> writes: > > Hi everyone, > > I commenced Tasigna last week - 400mg once a day and will commence 200mg > tonight, working my way up to 400mg. After the very unlovely side effects of > Glivec, I am hesitant about going up to " full " strength without a lead in > and my haem/t has been very supportive of this. > > So far I have tolerated 400mg with no problems, except that I have the worse > head cold I have had in years, which was developing before I started taking > Tasigna. > > Just a question for the more experienced - when fasting at night, can you > still have water? I hate to think what it will be like come summer if I > can't have any water for 3 hours! > > I was going to start last night, then forgot to take the capsule at 7pm, so > as we had family around to celebrate my daughter's birthday, I didn't take > it last night. I can see I am going to need to be very disciplined, which I > am not as I would often forget to take my Glivec at teatime and take later > in the night. > > Regards, > > from Down Under > > Rodorbal Labradors Australia > > <__http://www.rodorbalhttp:_ (http://www.rodorbalhttp_/) > (_http://www.rodorbalhttp:_ (http://www.rodorbal.com/) ) > www.rodorbal. > > <__http://au.groups.http://au.http://au.http://au_ > <http://au.groups.http:/au.http:/au.http:/au_> > (http://au.groups.http//au.http://au.groupsht_ > <http://au.groups.http/au.http:/au.groupsht_> ) > <_http://au.groups.http://auhttp://auhttp://au_ > <http://au.groups.http:/auhttp:/auhttp:/au_> > (http://au.groups.http/au.http:/au.groupsht_) > > (_http://au.groups.http://au.http://au.groupsht_ > <http://au.groups.http:/au.http:/au.groupsht_> > (http://au./group/Ozlabradors/) ) > > __http://au.groups.http://au.http://au.http://au_ > <http://au.groups.http:/au.http:/au.http:/au_> > (http://au.groups.http//au.http://au.groupsht_ > <http://au.groups.http/au.http:/au.groupsht_> ) > <_http://au.groups.http://auhttp://auhttp://au_ > <http://au.groups.http:/auhttp:/auhttp:/au_> > (http://au.groups.http/au.http:/au.groupsht_) > > (_http://au.groups.http://au.http://au.groupsht_ > <http://au.groups.http:/au.http:/au.groupsht_> > (http://au./group/Ozlabradors/) ) > > <__http://www.labradathttp:/_ (http://www.labradathttp:_) > (_http://www.labradathttp:/_ (http://www.labradata.org/) ) > www.labradata. > > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.