Guest guest Posted August 6, 2008 Report Share Posted August 6, 2008 : Regarding your Tasigna question. According to my oncologist, they want you to have an empty stomach, so liquids or solids are supposed to be kept to a minimum. It has to do with the absorption and efficacy in your system, from what I understand. A full stomach increases the potency and thus can trigger heart or organ issues. For me, it seems that the no food two hours before is the most important. I can tell if I eat and then take Tasigna that it is more potent, but not as much afterward. Just like Gleevec, you will find the things that work and do not work for you. The standard things to watch on Gleevec, you also need to watch on Tasigna including Tylenol, St. s Wart and Grapefruit Juice, to name just a few. A lot of people find, especially after loose stools from Gleevec, that they have constipation (a shock to your system, especially if you have been on Gleevec for several years) so I take my doses with a half of a glass of Metamucil and I have no problems. Another thing to watch out for is middle back pain. This may be a sign of high Lipase, which is a concern of toxicity in your pancreas, which I experienced early on as I made the adjustment. You should call your Oncologist if this occurs. One thing that I found on Tasigna was that I could drink, which I really could not on Gleevec. So maybe you have that to look forward to. I hope Tasigna works well for you. Matt Florida CML Army Zero Club Number Misplaced In a message dated 8/6/2008 4:55:44 A.M. Eastern Daylight Time, rodorbal@... writes: Hi everyone, I commenced Tasigna last week - 400mg once a day and will commence 200mg tonight, working my way up to 400mg. After the very unlovely side effects of Glivec, I am hesitant about going up to " full " strength without a lead in and my haem/t has been very supportive of this. So far I have tolerated 400mg with no problems, except that I have the worse head cold I have had in years, which was developing before I started taking Tasigna. Just a question for the more experienced - when fasting at night, can you still have water? I hate to think what it will be like come summer if I can't have any water for 3 hours! I was going to start last night, then forgot to take the capsule at 7pm, so as we had family around to celebrate my daughter's birthday, I didn't take it last night. I can see I am going to need to be very disciplined, which I am not as I would often forget to take my Glivec at teatime and take later in the night. Regards, from Down Under Rodorbal Labradors Australia <_http://www.rodorbalhttp_ (http://www.rodorbal.com/) > www.rodorbal. <_http://au.groups.http://au.http://au.groupsht_ (http://au./group/Ozlabradors/) > _http://au.groups.http://au.http://au.groupsht_ (http://au./group/Ozlabradors/) <_http://www.labradathttp:_ (http://www.labradata.org/) > www.labradata. [Non-text portions of this message have been removed] **************Looking for a car that's sporty, fun and fits in your budget? Read reviews on AOL Autos. (http://autos.aol.com/cars-BMW-128-2008/expert-review?ncid=aolaut00050000000017 ) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 6, 2008 Report Share Posted August 6, 2008 Hi everyone, I commenced Tasigna last week - 400mg once a day and will commence 200mg tonight, working my way up to 400mg. After the very unlovely side effects of Glivec, I am hesitant about going up to " full " strength without a lead in and my haem/t has been very supportive of this. So far I have tolerated 400mg with no problems, except that I have the worse head cold I have had in years, which was developing before I started taking Tasigna. Just a question for the more experienced - when fasting at night, can you still have water? I hate to think what it will be like come summer if I can't have any water for 3 hours! I was going to start last night, then forgot to take the capsule at 7pm, so as we had family around to celebrate my daughter's birthday, I didn't take it last night. I can see I am going to need to be very disciplined, which I am not as I would often forget to take my Glivec at teatime and take later in the night. Regards, from Down Under Rodorbal Labradors Australia <http://www.rodorbal.com> www.rodorbal.com <http://au./group/Ozlabradors/> http://au./group/Ozlabradors/ <http://www.labradata.org> www.labradata.org Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 6, 2008 Report Share Posted August 6, 2008 Hi Matt - thanks for the info, it is always good to get it first hand so to speak. I know that if you have food with Tasigna is a definite no no due to as you say, taking with food increases the absorption. I have a large glass of water with the capsule, so at least have a drink after 2 hours fasting. It's interesting with Glivec, that I never had a problem drinking alcohol with it and with Tasigna have only had 1 glass of wine so far, as with the cold I haven't felt like anything much. I hate grapefruit and it's juice, so no problem and never taken St s Wart. My haem't passed on all the info that Novartis sent him re contra indications, possible adverse effects etc as I am his first patient on Tasigna, so we will be learning together. It's great to have " thin " ankles again and eyes I can see out of! I was doing well on Glivec 200mg, but as I have only just had my first CML anniversary, it was felt it was too risky to continue on at this stage and I also had a low serum level. I am still taking my magnesium tablets as I know this can also be a problem with Tasigna. I have been on this drug 10 days now and it is a joy compared to Glivec and I have been able to stop taking diuretics and other medication I was taking for the migraines I was experiencing. Dr Tim our leading CML specialist told me that if you were to eat a fatty meal without fasting on Tasigna, that possible side effects could affect the heart (QT prolongation), palpatations and more likely to experience issues with pancreas and rises in serum amylase, lipase etc. I had a base line ECG and that was fine and my haem't is monitoring that closely. When you say " I can tell if I eat and then take Tasigna that it is more potent, but not as much afterward " , what sort of side effects do you get? Regards, from Downunder From: [mailto: ] On Behalf Of mtmaynor@... Sent: Wednesday, 6 August 2008 10:09 PM Subject: Re: [ ] tasigna : Regarding your Tasigna question. According to my oncologist, they want you to have an empty stomach, so liquids or solids are supposed to be kept to a minimum. It has to do with the absorption and efficacy in your system, from what I understand. A full stomach increases the potency and thus can trigger heart or organ issues. For me, it seems that the no food two hours before is the most important. I can tell if I eat and then take Tasigna that it is more potent, but not as much afterward. Just like Gleevec, you will find the things that work and do not work for you. The standard things to watch on Gleevec, you also need to watch on Tasigna including Tylenol, St. s Wart and Grapefruit Juice, to name just a few. A lot of people find, especially after loose stools from Gleevec, that they have constipation (a shock to your system, especially if you have been on Gleevec for several years) so I take my doses with a half of a glass of Metamucil and I have no problems. Another thing to watch out for is middle back pain. This may be a sign of high Lipase, which is a concern of toxicity in your pancreas, which I experienced early on as I made the adjustment. You should call your Oncologist if this occurs. One thing that I found on Tasigna was that I could drink, which I really could not on Gleevec. So maybe you have that to look forward to. I hope Tasigna works well for you. Matt Florida CML Army Zero Club Number Misplaced In a message dated 8/6/2008 4:55:44 A.M. Eastern Daylight Time, rodorbal@... <mailto:rodorbal%40westvic.com.au> writes: Hi everyone, I commenced Tasigna last week - 400mg once a day and will commence 200mg tonight, working my way up to 400mg. After the very unlovely side effects of Glivec, I am hesitant about going up to " full " strength without a lead in and my haem/t has been very supportive of this. So far I have tolerated 400mg with no problems, except that I have the worse head cold I have had in years, which was developing before I started taking Tasigna. Just a question for the more experienced - when fasting at night, can you still have water? I hate to think what it will be like come summer if I can't have any water for 3 hours! I was going to start last night, then forgot to take the capsule at 7pm, so as we had family around to celebrate my daughter's birthday, I didn't take it last night. I can see I am going to need to be very disciplined, which I am not as I would often forget to take my Glivec at teatime and take later in the night. Regards, from Down Under Rodorbal Labradors Australia <_http://www.rodorbalhttp_ (http://www.rodorbal.com/) > www.rodorbal. <_http://au.groups.http://au.http://au.groupsht_ <http://au.groups.http:/au.http:/au.groupsht_> (http://au./group/Ozlabradors/) > _http://au.groups.http://au.http://au.groupsht_ <http://au.groups.http:/au.http:/au.groupsht_> (http://au./group/Ozlabradors/) <_http://www.labradathttp:_ (http://www.labradata.org/) > www.labradata. Quote Link to comment Share on other sites More sharing options...
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