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Possible Mutation

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My name is and I am a 35-year old CML patient. I was dx'd on

Nov. 2001. I was on Gleevec until 2005 and became intolerant. I was

switched to Sprycel and it worked beautifully. I was PCRU for 2

years. With my doc from OHSU on board, we decided to get pregnant.

Things have not gone as well as expected. I am 6 months pregnant and

my test results continue to get worse.

*1/2003 - .97 (Baseline)

3/2008 - undetectable

6/2008 - .0076

7/2008 - .085

8/2008 - .31

In my last sample, my doctor says they found a mutation. It is not

the T315 but a rather new one. He used the term " insertion mutation. "

Can anyone shed light on this for me? I don't exactly understand

mutations but I need to know what is ahead for us. We are already

planning to have the baby early so that I can get back on treatment.

I just feel so helpless and my husband is worried sick.

Thanks in advance for any information.

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