Old CML drug side effects

[Guest guest]

Still long for the good old days??? This is what they used to give CML

patients: Myerlan and Busulfan. Think you have it bad now??????

a.. Nausea and vomiting (usually mild with standard doses).

b.. Diarrhea (usually mild with standard doses).

c.. Poor appetite.

d.. Mouth sores.

e.. Loss of fertility. Meaning, your ability to conceive or father a child

may be affected by busulfan. This effect is dose dependent. Discuss this issue

with your health care provider.

f.. Discoloration of the skin, especially in the creases of the hands and nail

beds.

g.. Skin rash

h.. Itching

a.. Lung problems, After long-term or high-dose therapy a syndrome known as

" busulfan lung " may occur. This may be a delayed toxicity occurring 1 to 10

years after discontinuation of treatment. Symptoms include cough, shortness of

breath and fever.

b.. Liver problems, seen with high dose therapy such as used in bone marrow

transplant setting. (syndrome consists of enlarged liver, jaundice, ascites and

liver failure).

c.. Adrenal insufficiency (low production of needed steroids produced by the

adrenal glands). Symptoms of adrenal insufficiency are:

d.. Fatigue, poor appetite, nausea, vomiting, diarrhea, weight loss,

weakness, and dizziness. Be sure your health care provider is aware if you are

experiencing these symptoms. If adrenal insufficiency occurs replacement

steroids may be needed.

e.. Seizures may occur with high doses used in bone marrow transplant.

Anti-seizure medications are often used to prevent this.

f.. Increased risk of secondary cancer such as acute leukemia especially

with long-term use of the drug. Discuss this with your doctor.

g.. http://www.chemocare.com/bio/busulfan.asp

Blessings,

Lottie

[Guest guest]

- I know CML patients who do have some really negative side effects to

gleevec and have been switched to sprycel or have had to go the transplant

route. While very grateful to have gleevec, sprycel, tasigna, they all do

carry some weighty side effects that can't be argued.

From: [mailto: ] On Behalf Of Lottie

Duthu

Sent: August-27-08 12:26 AM

CML

Subject: [ ] Old CML drug side effects

Still long for the good old days??? This is what they used to give CML

patients: Myerlan and Busulfan. Think you have it bad now??????

a.. Nausea and vomiting (usually mild with standard doses).

b.. Diarrhea (usually mild with standard doses).

c.. Poor appetite.

d.. Mouth sores.

e.. Loss of fertility. Meaning, your ability to conceive or father a child

may be affected by busulfan. This effect is dose dependent. Discuss this

issue with your health care provider.

f.. Discoloration of the skin, especially in the creases of the hands and

nail beds.

g.. Skin rash

h.. Itching

a.. Lung problems, After long-term or high-dose therapy a syndrome known as

" busulfan lung " may occur. This may be a delayed toxicity occurring 1 to 10

years after discontinuation of treatment. Symptoms include cough, shortness

of breath and fever.

b.. Liver problems, seen with high dose therapy such as used in bone marrow

transplant setting. (syndrome consists of enlarged liver, jaundice, ascites

and liver failure).

c.. Adrenal insufficiency (low production of needed steroids produced by the

adrenal glands). Symptoms of adrenal insufficiency are:

d.. Fatigue, poor appetite, nausea, vomiting, diarrhea, weight loss,

weakness, and dizziness. Be sure your health care provider is aware if you

are experiencing these symptoms. If adrenal insufficiency occurs replacement

steroids may be needed.

e.. Seizures may occur with high doses used in bone marrow transplant.

Anti-seizure medications are often used to prevent this.

f.. Increased risk of secondary cancer such as acute leukemia especially

with long-term use of the drug. Discuss this with your doctor.

g.. http://www.chemocare.com/bio/busulfan.asp

Blessings,

Lottie

[Guest guest]

-I have been on Gleevec 400mg per day and I am having alot of those

side affects. I have been on this drug for two years and just found

out my liver is enlarged and was told today there wasn't much they can

do for it because the gleevec is working.My stomach is real tender to

the touch but to walk I have to hold the spot.

-- In , " Lottie Duthu " <lotajam@...> wrote:

>

> Still long for the good old days??? This is what they used to give

CML patients: Myerlan and Busulfan. Think you have it bad now??????

> a.. Nausea and vomiting (usually mild with standard doses).

> b.. Diarrhea (usually mild with standard doses).

> c.. Poor appetite.

> d.. Mouth sores.

> e.. Loss of fertility. Meaning, your ability to conceive or

father a child may be affected by busulfan. This effect is dose

dependent. Discuss this issue with your health care provider.

> f.. Discoloration of the skin, especially in the creases of the

hands and nail beds.

> g.. Skin rash

> h.. Itching

> a.. Lung problems, After long-term or high-dose therapy a

syndrome known as " busulfan lung " may occur. This may be a delayed

toxicity occurring 1 to 10 years after discontinuation of treatment.

Symptoms include cough, shortness of breath and fever.

> b.. Liver problems, seen with high dose therapy such as used in

bone marrow transplant setting. (syndrome consists of enlarged liver,

jaundice, ascites and liver failure).

> c.. Adrenal insufficiency (low production of needed steroids

produced by the adrenal glands). Symptoms of adrenal insufficiency are:

> d.. Fatigue, poor appetite, nausea, vomiting, diarrhea, weight

loss, weakness, and dizziness. Be sure your health care provider is

aware if you are experiencing these symptoms. If adrenal

insufficiency occurs replacement steroids may be needed.

> e.. Seizures may occur with high doses used in bone marrow

transplant. Anti-seizure medications are often used to prevent this.

> f.. Increased risk of secondary cancer such as acute leukemia

especially with long-term use of the drug. Discuss this with your doctor.

> g.. http://www.chemocare.com/bio/busulfan.asp

> Blessings,

> Lottie

>

>