Re: Glivec plasma concentration

[Guest guest]

Barb

I had the PK level test done both in the Philidelphia lab through Druker

and at the new Novartis lab. Both came back 1100 - Not a significant

level to cause the side effects I had. I had a good response to gleevec

reaching PCRU in 9 months and holding it since. I think to test inside

the cells would be more accurate.

Best of health

Barb

>

> Has anyone else had this done?

> Mine was spot on at 1000 the other week.

> My Dr says that they've been seeing lots of discrepancies with these

> tests - people with good responses have low concentrations & people

> with poor responses have correct levels, same goes for side effects.

> Here in France, they're trying to develop a test to measure the

> concentration inside the cells instead of the blood.

>

[Guest guest]

G’day to the 2 Barb’s,

I had a PK level done back in June as due to severe side effects of Glivec

400mg, I had a break from Glivec for 6 weeks, then have been on 200mg since.

My PK level was only 480ng, which is obviously too low, but on 200mg I feel

great! It would have been interesting to see what it was when I was on

400mg.

I am having monthly PCRs at present, going from 13.01% (Jan) to 0.08%

(April), then 0.02% (May) after the break and last one was back to 0.09%

(June). Still waiting for my current results, it’s a pain having to wait 3

weeks or more for them.

We only have one lab in Australia where the test can be done and fortunately

it is only a 5 ½ hr drive, and I have a friend who lives there so a good

“girls” w/e away! Tim who is the leading specialist in CML in OZ,

told me that it is possible 200mg is fine for me, but as I was only dx last

July – gee my first anniversary is only a week away, he doesn’t want to

“risk” me developing resistance or mutations, so will be swapping me over to

Tasigna.

Tim made the comment at this stage that testing cannot be done at cellular

level – this would be great for me as would prove whether or not 480ng is a

therapeutic dose. But they are working on it – we have the PK test, so who

knows what they can do within the next few years?

Regards,

Down Under

_____

From: [mailto: ] On Behalf Of Barb

Stanley

Sent: Wednesday, 16 July 2008 11:29 PM

Subject: [ ] Re: Glivec plasma concentration

Barb

I had the PK level test done both in the Philidelphia lab through Druker

and at the new Novartis lab. Both came back 1100 - Not a significant

level to cause the side effects I had. I had a good response to gleevec

reaching PCRU in 9 months and holding it since. I think to test inside

the cells would be more accurate.

Best of health

Barb

>

> Has anyone else had this done?

> Mine was spot on at 1000 the other week.

> My Dr says that they've been seeing lots of discrepancies with these

> tests - people with good responses have low concentrations & people

> with poor responses have correct levels, same goes for side effects.

> Here in France, they're trying to develop a test to measure the

> concentration inside the cells instead of the blood.

>

[Guest guest]

I had the test done in 2007 as I was not getting better than 2ish log

reduction for over two years, and I had a plasma level of 600ng, which

is below the optimal 1000 but now my PCR is to low to get a number,

although it still is positive (-4 or 5 log reduction), and I stayed at

400mg of gleevec a day. The test was done by the lab in Toulouse

France, even if I live in California (the blood got shipped at

Novartis expense). Yes there is a large variance of results around the

1000ng optimal value. My dr at Saint Louis hospital in Paris, who did

the referral for the test, told me above 500ng is acceptable as long

as the PCR results are good.

Marcos.

On Wed, Jul 16, 2008 at 5:18 AM, Barbara Meunier <Barbsm@...> wrote:

> Has anyone else had this done?

> Mine was spot on at 1000 the other week.

> My Dr says that they've been seeing lots of discrepancies with these

> tests - people with good responses have low concentrations & people

> with poor responses have correct levels, same goes for side effects.

> Here in France, they're trying to develop a test to measure the

> concentration inside the cells instead of the blood.

>

>

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 614 2305

650 630 5015 (cell)

marcospg@...

montereyunderwater@...

www.stanford.edu/~marcospg/