Guest guest Posted January 11, 2009 Report Share Posted January 11, 2009 Hi all I was told by my oncologist that Sprycel has 10 times the chemo effect of Glivec. That's why most people who don't get enough of a response on Glivec have had to turn to Sprycel, which would make sense. Is this true? Jackie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 11, 2009 Report Share Posted January 11, 2009 I have heard it was twice as strong but do not know for sure. Almost want to say i read it somewhere but was a year ago probably Anita ________________________________ From: Jackie Petropoulos <jackie@...> Sent: Saturday, January 10, 2009 7:09:31 PM Subject: RE: [ ] Glivec v Sprycel Hi all I was told by my oncologist that Sprycel has 10 times the chemo effect of Glivec. That's why most people who don't get enough of a response on Glivec have had to turn to Sprycel, which would make sense. Is this true? Jackie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 11, 2009 Report Share Posted January 11, 2009 In vitro Dasatinib (brand name Sprycel) is said to be up to 300 times more potent than imatinib (Gleevec), but that's not the reason it may be a solution for people that fail Gleevec, and dose limiting toxicity is well below the concentration corresponding to 300 times imatinib. The main reason is that Sprycel is active against more mutations of the leukemia cells (BCR-ABL cells). The other reason is the side effects are different and people that are or become intolerant to gleevec may do well with Sprycel. Same thing with Tasigna (nilotinib). But these two newer drugs don't have yet the safety record of Gleevec, so if Gleevec is working and side effects are ok it's still a better bet. And financially, the pattern for imatinib (the molecule in Gleevec) will be over sooner (around 2012 ?) and it will be available as generic for a fraction of the cost of Gleevec. With the current trend in health insurance to push cancer drugs to less covered tiers it may be a big factor for many patients. Marcos. On Sat, Jan 10, 2009 at 5:09 PM, Jackie Petropoulos <jackie@...>wrote: > Hi all > > I was told by my oncologist that Sprycel has 10 times the chemo effect of > Glivec. That's why most people who don't get enough of a response on Glivec > have had to turn to Sprycel, which would make sense. > > Is this true? > > Jackie > > Quote Link to comment Share on other sites More sharing options...
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