Bosutinib or SKI 606 abstract

[Guest guest]

Hi Lottie and others on the SKI drug. This one's for you.

http://ash.confex.com/ash/2008/webprogram/Paper2950.html

SKI606 (AKA Bosutinib) is a combination src/abl inhibitor with

minimal activity against PDGFR and c-kit and is currently being used

on patients who have failed prior Gleevec therapy with some patients

having failed more than just Gleevec.

Many of the patients had mutations, in fact 15 different mutations

were found in 32 patients.

11 patients have left the trial due to side effects.

The results are broken down into several categories...the various

stages of CML (chronic, accelerated, blast), as well as for those who

had only Gleevec as prior therapy versus those who had more than just

Gleevec etc so there are a lot of numbers to sort through.

Tracey