gleevec interactions

[Guest guest]

Hi all,

I hope everybody is having good hollidays. Everything is fine for me now

with the kidney stone, but here is something that may be of interest for the

list. I finished last week passing the debris from the laser surgery of Dec

22, what went well with moderate pain for which I took some aceminatophen

staying well below maximun daily doses. I did take some

tylenol before without any problems, my liver counts have always been very

good, although it hasn't been tested for about a year. So Wednesday I took

2000mg during the day and Thursday 1000mg. I decided to stay away from the

vicodin (hydrocodone+aceminatophen) as the pain was moderate and I was

getting constipated from the narcotics (morphin at the surgery wakeup, and

vicodin a couple of times Monday evening and Tuesday). When they prescribed

the vicodin I argued a bit about interaction with gleevec, the last thing I

want is to become intolerant to imatinib. But they told me the hydrocodone

was fine and the aceminatophen in the vicodin is only 325mg in the pill they

gave me (usually it is 500mg). Well, Thursday evening I started to feel a

bit nauseous but went to bed and fell asleep quickly. I woke up in the

middle of the night feeling really nauseous and this time couldn't sleep

until the morning. I discontinued all medications beside the antibiotic

(septra) and pushed the gleevec pill to the evening (usually I take it at

lunch). By Saturday I was better and resumed the gleevec at lunch as usual.

I didn't need any pain medication since and I am done with the septra. Now I

am just fine. I checked up on hydrocodone and it does have interactions with

gleevec, of the same kind than aceminatophen, the combination is potentially

bad for the liver. Vicodin is probably not ideal with gleevec, next time I

am going to argue a bit more. I didn't look extensively for the other drugs

(septra, azo, morphine, whatever they gave me for anesthesia) but my guess

it's a case of too many drugs in the system overcharging my poor hard

working liver. Now I feel fine but I ll ask the hematologist for liver

testing this month to make sure things are back the way they were.

Marcos

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 614 2305

650 468 9926 (cell)

marcospg@...

montereyunderwater@...

www.stanford.edu/~marcospg/