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http://www.naturalnews.com/025722.html

(NaturalNews) Where did I leave my keys? Who am I supposed to call again? What

did I mean by that scribbled note, anyway? Everybody experiences these incidents

of forgetfulness.

As we get older, these kinds of memory lapses can become routine, and are

casually attributed to " advancing years " by many baby boomers, according to Dr.

Heidi White, assistant professor of geriatric medicine at Duke University

Medical Center.

Age isn`t the only factor in memory loss, however, says White. She notes that

among possible causes for cognitive decline are medications (such as sedatives,

which can dull the mind), depression (which affects concentration), and hearing

or vision impairment.

Baby boomers and the battle for the mind

Keeping the brain healthy much longer is a goal of many of us, especially people

who, as of this writing, were 45 to 63 years old - otherwise called baby

boomers. If you consider that a baby boomer turns 50 every 7.5 seconds, by the

year 2024 there will be 115 million people over age 50 in the U.S.

Today, approximately 78 million people, about 26 percent of the total U.S.

population, were not only born between 1946 and 1964 but are, say demographers

and researchers, greatly concerned about loss of memory and the aging of the

mind.

True failing memory is different from the forgetfulness of a busy person or the

stereotypical absentminded professor. Clinically speaking, failing memory is

often accompanied by a person`s declining sense of well-being, and is often

described by symptoms such as a lack of mental clarity (brain fog), altered mood

(as in depression), decreased mental abilities, worsening sleep patterns, and

declining overall energy.

Age of Information Overload

Whence the brain drain? Some researchers believe our brains are overtaxed today.

Not many would disagree that we`ve moved beyond the Information Age into the

" Age of Information Overload. " It`s believed that our cognitive processing, and

maybe even our memory storage capacity itself, can become overburdened as we

age.

To one extent or another, there`s little doubt that all of us are bombarded by

work and personal e-mail, Internet spam and junk mail, faxes, magazines, 24-hour

news, digital pages, telemarketer calls, cell phone voice-mail and even the

arcane logistics of play-date scheduling for the kids after school!

Cognition is sensitive to a wide variety of nutritional factors, and modern

nutritional science is uncovering that we can improve our mental powers

effectively, and even powerfully, through a wide array of nutrients and

supplements, including antioxidants, herbs, fats and other targeted dietary

supplements.

A November 2008 review in the Journal of the American Nutraceutical Association

pointed to benefits of a variety of bioactive nutritional supplement ingredients

(often called nutraceuticals), some of which we will look at, in slowing

age-associated memory impairment. Vinpocetine and acetyl-L-carnitine were

especially effective, followed by huperzine A; rhodiola; ginseng and alpha

lipoic acid. The least effective compounds were the drugs, Aricept and Nemanda.

The brain train - vitamins to the rescue

Vitamin C. To test whether vitamin C protects against mental decline, called

" cognitive impairment " in this study, researchers from Australia`s University of

Sydney looked at 117 elderly people in a retirement community over a four-year

period --- those who took vitamin C supplements and those who did not. Seniors

who took vitamin C supplements experienced a lower incidence of severe cognitive

decline. The authors concluded that, " Vitamin C might protect against cognitive

impairment. "

Vitamin E. Research from Italy and the U.S. has shed new light on vitamin E`s

role in brain health. A July 2005 study by Italian researchers from Perugia`s

Institute of Gerontology and Geriatrics (the InCHIANTI study) included 1,033

participants aged 65 and older. The research group found that people with the

lowest blood levels of vitamin E had the highest incidence of senile dementia

and " cognitive impairment " compared to those who had the highest vitamin E

levels.

Another 2005 study, this out of Chicago`s Rush Institute for Healthy Aging,

studied 6158 people 65 years of age or older between 1993 and 2002, including a

subset of 1,041 patients who were clinically evaluated. The researchers, led by

Martha C. , Sc.D., found that higher intakes of vitamin E were associated

with a reduced incidence of Alzheimer`s disease.

Other recent studies have looked at different combinations of vitamins and

minerals, with vitamins C and E as a foundation.

ALA anyone?

Alpha lipoic acid is a very powerful brain-friendly antioxidant that has been

found to directly restore vitamin C and glutathione to their active forms (after

they have been used up) and to indirectly restore vitamin E to its powerful

form, as well.

In animals, alpha lipoic acid protects brains cells against beta amyloid plaque,

the buildup of which is associated with dementia and Alzheimer`s disease. In

fact, animal studies published in 2002 and 2003 showed that treatment with alpha

lipoic acid prevented or reversed cognitive impairment similar to dementia in

humans.

In 2001, researchers gave nine patients with Alzheimer`s disease 600 mg each day

of ALA in addition to Aricept or Exelon for an average of one year. This was the

first such study to find that treatment with alpha lipoic acid may be

" neuroprotective " against Alzheimer`s disease and related dementias.

In a 2007 follow-up, 43 ALA-supplemented patients were observed for a period of

up to 48 months. In patients with mild dementia, the disease progressed

extremely slowly; in patients with moderate dementia, dementia progressed twice

as slowly.

B is for brain

In the American Journal of Geriatric Psychiatry, researchers looked at 69 people

with Alzheimer`s disease, including 33 patients who were taking a multivitamin

supplement of folic acid, vitamin B6 and vitamin B12.

In the 66 patients who were available for the eight-week follow-up, the

high-dose B-vitamin supplement significantly reduced levels of homocysteine,

which is important since high levels of homocysteine may be associated with the

breakdown of the myelin sheaths that encase nerves and may be partly responsible

for the symptoms of Alzheimer`s-like dementia.

Botanical brain boosters

Ginkgo. Since stress in humans is associated with decreased memory and learning

function, Polish scientists gave an extract of Ginkgo biloba (EGb 761 or

Ginkgold) to rats that had been chronically stressed. According to their study,

the supplement improved memory and cognition in all rats, including those that

had been stressed.

The last 30 years have yielded a large body of evidence supportive of ginkgo

supplementation for brain-boosting, although some studies have studied the wrong

groups, have looked for the wrong results or have used too low a dose. According

to 2000 review by New York University`s P.L. LeBars, daily dosages of 240 mg a

day appeared to demonstrate the most benefit in patients with memory disorders

or dementia.

Ginseng. In 2008, a group of South Korean researchers published the results of

an open-label study in which patients with Alzheimer`s disease received Panax

ginseng extract or a placebo for 12 weeks. In the ginseng-supplemented group,

all main measures cognitive performance began to show improvements and continued

for up to 12 weeks. After discontinuing ginseng, the improved scores declined to

the levels of the control group. According to the authors, " These results

suggest that Panax ginseng is clinically effective in the cognitive performance

of [Alzheimer`s disease] patients. "

Pomegranate. A 2005 rodent study found that drinking pomegranate juice during

pregnancy may lower the risk of hypoxia ischemia-related brain injuries (a

condition caused by decreased blood flow and oxygen to the fetal brain) in

babies. The authors said their results " demonstrate that maternal dietary

supplementation with pomegranate juice is neuroprotective for the neonatal

brain. "

A more recent study in newborn mice, published in 2007, suggest that special

compounds in pomegranate, polyphenols, should be further investigated as a

potential treatment to decrease brain injury due to neonatal hypoxia-ischemia.

Vinpocetine. Vinpocetine is a supplement that`s derived from vincamine, an

extract of the periwinkle plant (Vinca minor). Widely used and studied in Europe

for over 25 years, awareness of this product and the research behind is now

starting to come into its own.

A 2001 review (meta-analysis) in the Journal of the American Nutraceutical

Association by the University of Miami`s Bernd Wollschlaeger, M.D., winnowed

down 39 vinpocetine studies involving 1,912 subjects into three studies - from

1986 through 1991 - involving a total of 174 patients treated with vinpocetine

and 114 given a placebo.

According to Wollschlaeger, all three studies " suggest a significant [mental]

improvement in the cognitive function of patients suffering from dementia or

other symptoms of cerebrovascular diseases. " Based on several mental-performance

tests, the significant improvement in cognitive function, in these three

studies, says Wollschlaeger, " suggest a clinical application of vinpocetine

in the early phases of mild cognitive impairment " before full-blown " senile

dementia " or Alzheimer`s disease start to develop.

" Designer " supplements for brain support

Acetyl-L-carnitine (ALC). A 2004 review of 21 double-blind, placebo-controlled

studies using acetyl-L-carnitine in the treatment of " mild cognitive impairment "

and mild Alzheimer`s disease showed significant improvements versus the placebo

or " dummy " pills.

CDP-choline. A relative of phosphatidylserine (PS), cytidine-5-diphosphocholine,

or CDP-choline, has been attracting some recent research interest. In 2005,

scientists from the Massachusetts Institute of Technology (MIT) found, in an

animal study, that long-term supplementation with CDP-choline may hold back

memory impairment.

Huperzine A. Huperzine A is a purified substance derived from Chinese club moss

(Huperzia serrata). A 2005 paper on this supplement speculated that the

beneficial effects in Alzheimer`s disease are probably due to several cell- and

neuro-protective effects operating at the same time.

Food-based mental mojo?

In a 2004 observational study from the U.K. looking at dietary supplement use,

people born in 1936 received mental ability testing in 1947 and later in

2000-2001. At age 64, cognitive function was better in dietary supplement users

than in non-users, especially in those people who were also taking marine oil

supplements.

Quality of mind = quality of life

Many would argue that quality of mind - a well functioning brain - is truly at

the elemental core of quality of life; therefore, ways in which we can improve

our mental abilities and functions, and fend off the memory and general

cognitive declines associated with aging, should be more than welcome -

especially when these ways are holistic, supplement-based, and without the

profound unwanted side effects often associated with synthetic pharmaceutical

drugs.

References

Gormley J and Liberman S. User`s Guide to Brain-Boosting Supplements. North

Bergen, NJ: Basic Health Publications, 2004.

Reynolds J et al. Retarding cognitive decline with science-based nutraceuticals.

Journal of the American Nutraceutical Association. 11(1):19-27, 2008.

Paleologos M et al. Cohort study of vitamin C intake and cognitive impairment.

Am J

Epidemiol. 148(1):45-50, 1998.

Cherubini A et al. Vitamin E levels, cognitive impairment and dementia in older

persons: the InCHIANTI study. Neurobiol Aging. 26(7):987-994, 2005.

MC et al. Relation of the tocopherol forms to incident Alzheimer disease

and to cognitive change. Am J Clin Nutr. 81(2):508-514, 2005.

Arivazhagan P and Panneerselvam C. Neurochemical changes related to ageing in

the rat brain and the effect of DL-alpha-lipoic acid. Exp Gerontol.

37(12):1489-1494, 2002.

Sharma M and Gupta YK. Effect of alpha lipoic acid in intracerebroventricular

streptozotocin model of cognitive impairment in rats. Eur Neuropsychopharmacol.

13(4):241-247, 2003.

Farr SA et al. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse

memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem.

84(5):1173-1183, 2003.

Hager K et al. Alpha-lipoic acid as a new treatment option for Alzheimer type

dementia. Arch Gerontol Geriatr. 32(3):275-282, 2001.

Hager K et al. Alpha-lipoic acid as a new treatment option for Alzheimer`s

disease - a 48 months follow-up analysis. J Neural Transm Suppl. 72:189-193,

2007.

Aisen PS et al. A pilot study of vitamins to lower plasma homocysteine levels in

Alzheimer`s disease. Am J Geriatr Psychiatry. 11(2):246-249, 2003.

Walesiuk A et al. Ginkgo biloba extract diminishes stress-induced memory

deficits in rats. Pharmacol Rep. 57(2):176-187, 2005.

LeBars PL and Kastelan J. Efficacy and safety of a Ginkgo biloba extract. Public

Health Nutrition. 3(4A):495-499, 2000.

Lee ST et al. Panax ginseng enhances cognitive performance in Alzheimer disease.

Alzheimer Dis Assoc. Disord. 22(3):222-226, 2008.

Loren DJ et al. Maternal dietary supplementation with pomegranate juice is

neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury.

Pediatr Res. 57(6):858-864, 2005.

West T et al. Pomegranate polyphenols and resveratrol protect the neonatal brain

against hypoxic-ischemic injury. Dev Neurosci. 29(4-5):363-372, 2007.

Wollschlager B. Efficacy of vinpocetine in the management of cognitive

impairment and memory loss. Journal of the American Nutraceutical Association.

4(2):25-30, 2001.

Ames BN and Liu J. Delaying the mitochondrial decay of aging with

acetylcarnitine. Ann N Y Acad Sci. 1033:108-116, 2004.

Teather LA and Wurtman RJ. Dietary CDP-choline supplementation prevents memory

impairment caused by impoverished environmental conditions in rats. Learn Mem.

12(1):39-43, 2005.

Wang R Tang XC. Neuroprotective effects of huperzine A: a natural cholinesterase

inhibitor for the treatment of Alzheimer`s disease. Neurosignals. 14(1-2):71-82,

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Whalley LJ et al. Cognitive aging, childhood intelligence, and the use of food

supplements: possible involvement of n-3 fatty acids. Am J Clin Nutr.

80(6):1650-1657, 2004.

Muhammad Ahmad Al-Masry

64, Muhammad Korayem Street,

Gomrok, andria, Egypt

Tel: 0020-03-4800555

Fax: 0020-03-3082667

Web: massrii@...

massrii@...

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