Re: [Rejuvenation] Deprenyl

[Guest guest]

I investigated this potential problem of mixing Selective Serotonin Re-uptake

Inhibitors (SSRI's, e.g, Prozac, Zoloft) with selegiline (Deprenyl) a while

back, and while there were some concerns my general conclusion was that it

was a non-problem for normal anti-aging dosages of selegiline.

Problems might occur at doses of approximately 10mg/day of selegiline or more

because at such high doses selegiline inhibits MAO-A as well as MAO-B, but

10mg/day of selegiline is far more than is normally recommended for anti-

aging purposes. And even at these higher doses the problem is far from

obvious. SSRI's are very selective drugs and as such they have only a minor

effect on the neurotransmitters of concern (e.g., dopamine}. SSRI's do little

other than cause an increase in serotonin, which is not in and of itself a

problem in the presence of a MAO inhibitor.

-gts

--- Re: [Rejuvenation] Deprenyl

Dear Rampatro,

It is my understanding that Deprenyl is used to inhibit MAO-B, and the

" cheesy " effect applies to MAO-A so I don't think you have to worry

about diet. I used to have a good article on the SSRI (serotonin

secondary reuptake inhibitors), and MAO-A, but I can't find it now.

However if I recall you did have to watch out for the cheesy effect on

them, since they did affect MAO-A. I will look so more and try to pass

on more details.

Someone else on the board should have this info and I think that Gordon

(longevity) has good knowledge on this.

Sorry I could be of more help.

Dale

rampatro wrote:

> I have long been interested in the use of deprenyl as an anti-aging

> tool. I

> did review the animal studies and found the results impressive

> ('intoxicating' might be more accurate). Even more than longevity, the

>

> ability of deprenyl to retard the deterioration of mental faculties

> cannot

> (must not?) be ignored.

>

> What bothers me is that I am told that theraputic use of deprenyl is

> strongly contra indicated in those patients using Seratonin Uptake

> Inhibitors. Does anyone know anything about this?

>

> {I have heard that it is contra indicated with... cheese... but aside

> from that, I have not heard what you say here. What is a Seratonin

> Uptake Inhibitor? Ellis}

>

> I cannot, indeed will not, criticize those who eschew HRT because of

> their

> conservative natures. Yet my fears are fears of omissions. Deprenyl is

> far

> too important to ignore. Please advise.

>

> {Deprenyl is part of my own program. But the big question is what is

> the

> right dose to take? There is some conflict of opinion of whether it

> is

> one 5 mg pill per day, or per week... I take one per week, or none at

> all.

> My rationale for that is that I also take growth hormone, and I hope

> growth

> hormone is also keeping my MAO-B levels down. I have no way of

> knowing if

> I am right or if I am wrong. Too much Deprenyl also is bad for you,

> it seems.

> So...I dont know what is best. Can anybody give a better answer? I

> agree... this is important. - Ellis}

>

>

>

>

> RAM

>

>

> Thank you very much.

>

>

> Rampatro

>

>

>

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