The tissue effects of mineralocorticoids

[Guest guest]

This article says, " Many extrarenal tissues are affected by aldosterone:

the sweat and salivary glands, the gastrointestinal tract, skeletal and

smooth muscle, heart, bone and red blood cells. "

Do spiro & Inspra block the effect of aldo on these other tissues?

Val

The American Journal of Medicine

Volume 53, Issue 5, November 1972, Pages 561-572

http://www.sciencedirect.com/scidirimg/clear.gifdoi:10.1016/0002-9343(72)901

53-2

Copyright C 1972 Published by Excerpta Medica Inc.

The tissue effects of mineralocorticoids

J. Mulrow M.D.

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Forman M.D.

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, New Haven, Connecticut, USA

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Abstract

Aldosterone is the major mineralocorticoid secreted by the human adrenal

cortex and the kidney is its main target organ. Micropuncture investigations

indicate an enhancement of sodium reabsorbtion and potassium excretion in

the distal tubule by mineralocorticoids. Whether they affect the proximal

tubule is controversial. Prolonged administration of mineralocorticoids to

normal man results in transient sodium retention but persistent kaliuresis

and the development of hypertension. The mechanism of this hypertension is

still an enigma.

In addition to an effect on sodium and potassium, aldosterone can influence

the excretion of hydrogen, calcium and magnesium ions and the secretion of

renin. Many extrarenal tissues are affected by aldosterone: the sweat and

salivary glands, the gastrointestinal tract, skeletal and smooth muscle,

heart, bone and red blood cells.

[Guest guest]

Aldo effects are to react with a nuclear receptor

the MCR which triggers protein syn ENaC etc

Spiro occupies the MC so aldo can't do it's buusiness

Cortisol can also occupy MCR but renal MCR is protected

By 11bhd so it can't hat to receptor

More details in my art on evolution

Sent from my iPhone

On Aug 25, 2008, at 11:58 AM, Valarie <val@...> wrote:

> This article says, " Many extrarenal tissues are affected by

> aldosterone:

> the sweat and salivary glands, the gastrointestinal tract, skeletal

> and

> smooth muscle, heart, bone and red blood cells. "

>

> Do spiro & Inspra block the effect of aldo on these other tissues?

>

> Val

>

> The American Journal of Medicine

> Volume 53, Issue 5, November 1972, Pages 561-572

>

> http://www.sciencedirect.com/scidirimg/clear.gifdoi:10.1016/0002-9343(72)901

> 53-2

> Copyright C 1972 Published by Excerpta Medica Inc.

>

> The tissue effects of mineralocorticoids

> J. Mulrow M.D.

> <http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6TDC-4C0MVY4-22 & _

> user=

> 10 &

> _coverDate=11%2F30%2F1972 & _rdoc=4 & _fmt=high & _orig=browse & _srch=doc-i

> nfo(%23toc%235195%231972%23999469994%23490260%23FLP%23display

> %23Volume) & _cdi

> =5195 &

> _sort=d & _docanchor= & view=c & _ct=17 & _acct=C000050221 & _version=1 & _urlVers

> ion=0 & _userid=10 & md5=92c2cb58dd015d55ebbf53cd881b4a9c#m4.cor*>

> Corresponding

> Author Contact Information,

> <http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6TDC-4C0MVY4-22 & _

> user=

> 10 &

> _coverDate=11%2F30%2F1972 & _rdoc=4 & _fmt=high & _orig=browse & _srch=doc-i

> nfo(%23toc%235195%231972%23999469994%23490260%23FLP%23display

> %23Volume) & _cdi

> =5195 &

> _sort=d & _docanchor= & view=c & _ct=17 & _acct=C000050221 & _version=1 & _urlVers

> ion=0 & _userid=10 & md5=92c2cb58dd015d55ebbf53cd881b4a9c#fn1> 1 and

> Barr H.

> Forman M.D.

> <http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6TDC-4C0MVY4-22 & _

> user=

> 10 &

> _coverDate=11%2F30%2F1972 & _rdoc=4 & _fmt=high & _orig=browse & _srch=doc-i

> nfo(%23toc%235195%231972%23999469994%23490260%23FLP%23display

> %23Volume) & _cdi

> =5195 &

> _sort=d & _docanchor= & view=c & _ct=17 & _acct=C000050221 & _version=1 & _urlVers

> ion=0 & _userid=10 & md5=92c2cb58dd015d55ebbf53cd881b4a9c#fn1> 1

> , New Haven, Connecticut, USA

>

>

> References and further reading may be available for this article. To

> view

> references and further reading you must

> <http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6TDC-4C0MVY4-22 & _

> user=

> 10 &

> _coverDate=11%2F30%2F1972 & _rdoc=4 & _fmt=full & _orig=browse & _srch=doc-i

> nfo(%23toc%235195%231972%23999469994%23490260%23FLP%23display

> %23Volume) & _cdi

> =5195 &

> _sort=d & _docanchor= & view=c & _ct=17 & _version=1 & _urlVersion=0 & _userid=10 &

> md5=6e024c46429f2ac73e3ca6a31dc19d61> purchase this article.

> Abstract

>

> Aldosterone is the major mineralocorticoid secreted by the human

> adrenal

> cortex and the kidney is its main target organ. Micropuncture

> investigations

> indicate an enhancement of sodium reabsorbtion and potassium

> excretion in

> the distal tubule by mineralocorticoids. Whether they affect the

> proximal

> tubule is controversial. Prolonged administration of

> mineralocorticoids to

> normal man results in transient sodium retention but persistent

> kaliuresis

> and the development of hypertension. The mechanism of this

> hypertension is

> still an enigma.

>

> In addition to an effect on sodium and potassium, aldosterone can

> influence

> the excretion of hydrogen, calcium and magnesium ions and the

> secretion of

> renin. Many extrarenal tissues are affected by aldosterone: the

> sweat and

> salivary glands, the gastrointestinal tract, skeletal and smooth

> muscle,

> heart, bone and red blood cells.

>

>

>