BBs & thyroid

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Clinical Endocrinology

Volume 18 Issue 2 Page 139-142, February 1983

Clinical Endocrinology 18 (2) , 139–142

doi:10.1111/j.1365-2265.1983.tb03196.x

Abstract

DIFFERENT EFFECTS OF PROPRANOLOL, ALPRENOLOL, SOTALOL, ATENOLOL AND

METOPROLOL ON SERUM T3 AND SERUM rT3 IN HYPERTHYROIDISM

• H. PERRILD11Department of Internal Medicine and Endocrinology F, Herlev

Hospital, 2730 Herlev, Denmark,

• J. MØLHOLM HANSEN11Department of Internal Medicine and Endocrinology F,

Herlev Hospital, 2730 Herlev, Denmark,

• L. SKOVSTED11Department of Internal Medicine and Endocrinology F, Herlev

Hospital, 2730 Herlev, Denmark AND

• L. KORSGAARD CHRISTENSEN11Department of Internal Medicine and

Endocrinology F, Herlev Hospital, 2730 Herlev, Denmark

• 1Department of Internal Medicine and Endocrinology F, Herlev Hospital,

2730 Herlev, Denmark

•

SUMMARY

Serum T4, T3, rT3 and T3 resin uptake (T3 RU) were measured before and after

7 days of treatment with either propranolol, alprenolol, sotalol, atenolol

or metoprolol in hyperthyroid patients. We found a significant decrease in

serum T3 after propranolol, alprenolol, atenolol and metoprolol but no

change in the sotalol treated group. A significant increase in rT3 was found

in the propranolol [ex. Inderal] and alprenolol treated groups whereas a

significant fall in rT3 was found in the atenolol [ex Tenormin] and

metoprolol [Toprol XL] treated groups. No change was found in the sotalol

treated group. The changes observed in serum T3 and in rT3 could be

explained by an inhibition of the 5'deiodinase enzyme by propranolol and

alprenolol and an inhibition of both the 5'deiodinase and 5 deiodinase

enzymes caused by atenolol and metoprolol.

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