Re: Clinical trial (impaired glucose tolerance)

[Guest guest]

Aldo also affects insulin use by the cell ie insulin resistance. Thus

early PA likely causes metabolic syndrome.

Of course being overweight is a big problem as well. Don't know if aldo

makes people eat more.

It may make then eat more sodium.

On Mar 21, 2008, at 10:23 AM, Valarie wrote:

> http://clinicaltrials.gov/ct2/show/NCT00173082?

> term=primary+aldosteronism

>

> <http://clinicaltrials.gov/ct2/show/NCT00173082?

> term=primary+aldosteronism & r

> ank=1> & rank=1

>

> Detailed Description:

> Primary aldosteronism (PA) is occasionally associated with impaired

> glucose

> tolerance. Glucose intolerance, in general metabolic syndrome is

> caused by

> suppression of insulin release from the pancreas and suppression of

> insulin

> sensitivity of the target tissues. Several studies have suggested that

> impaired glucose tolerance in primary aldosteronism is due to an

> inability

> of the beta cells to release insulin by potassium depletion. It was

> suggested glucose intolerance in PA is caused by the suppression of

> insulin

> release related to hypopotassemia and compensatory increase of insulin

> sensitivity is observed in PA. The increased insulin secretory

> capacity

> associated with correction of negative potassium balance may account

> for the

> increase in plasma leptin after curing primary aldosteronism. The

> conclusion

> with respect to the possible causal relationship between DM and PA,

> however,

> can be obtained after the evaluation of the effect of surgical

> /pharmacological treatment of PA. From July 2005 to July 2008,

> patients with

> primary aldosteronism, hospitalized for a comprehensive study of the

> subtypes of primary aldosteronism before operation will receive

> informed

> consent about the insulin sensitivity test. In the present study, we

> measured insulin sensitivity via the ability to release insulin by

> the 75 g

> oral glucose tolerance test (OGTT) in PA to clarify the mechanisms of

> glucose intolerance in PA. Seventy-five gram OGTT was performed in PA

> before

> and after adrenalectomy. Within one minute, 75 g of glucose dissolved

> in 200

> cc water was ingested. Venous blood samples were drawn at 0, 60, 120

> minutes

> for determination of plasma glucose and plasma insulin levels. Serum

> potassium levels were measures at 0 minutes. Furthermore, the

> adipokines,

> HOMA, QUICKI, leptin, adiponectin, homocystine, C-reactive protein,

> proinflammatory cytokine and adhesion molecules were also measured.

>

>

>