Chronic treatment with the mineralocorticoid hormone aldosterone results in increased anxiety-like behavior

[Guest guest]

Ha! I'm not crazy! But he who says PA has no symptoms is limited.

Val

_______________________

Hormones and Behavior

Volume 54, Issue 1, June 2008, Pages 90-97

Chronic treatment with the mineralocorticoid hormone aldosterone results in

increased anxiety-like behavior

Natasa Hlavacova and a Jezova

Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental

Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06, Bratislava,

Slovakia

References and further reading may be available for this article. To view

references and further reading you must purchase

<http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6WGC-4RWH8D1-1 & _u

ser=10 & _coverDate=06%2F30%2F2008 & _alid=782243165 & _rdoc=58 & _fmt=full & _orig=se

arch & _cdi=6819 & _sort=d & _docanchor= & view=c & _ct=4695 & _acct=C000050221 & _version

=1 & _urlVersion=0 & _userid=10 & md5=c45cdd37aa2f76ad9746f3cc3b038b7f> this

article.

Abstract

Aldosterone is the last component of the renin–angiotensin–aldosterone

system inducing its peripheral effects via mineralocorticoid receptors (MR).

Brain MR bind preferentially glucocorticoids. So far, the role of MR in

behavioral functions has been investigated almost exclusively in relation to

glucocorticoids. Recently, aldosterone itself has been linked to affective

disorders. The aim of this study was to test the hypothesis that chronic

elevation of circulating levels of aldosterone leads to increased anxiety.

We have investigated the effects of chronic aldosterone treatment on (1)

anxiety-like behavior, and (2) basal and stress-induced levels of selected

hormones. Forty male Wistar rats were subcutaneously implanted with osmotic

minipumps and treated with aldosterone (2 µg/100 g/day) or vehicle for two

weeks. Aldosterone concentrations in plasma showed a mild (approximately

four-fold) increase at the end of two-week aldosterone treatment. This mild

hyperaldosteronism resulted in a significant enhancement of anxiety as

demonstrated by alterations in all indicators of anxiety-like behavior

measured in the open field and elevated plus-maze tests, without significant

changes in measures of general locomotor activity. Aldosterone treatment

affected not only the spatiotemporal measures of anxiety, but also the

ethological parameters related to exploration and risk assessment. Chronic

treatment with aldosterone was associated with increased water intake and

decreased plasma renin activity, but failed to modify basal or

stress-induced activity of the hypothalamic–pituitary–adrenocortical axis.

The results provide evidence on anxiogenic action of prolonged increase in

circulating aldosterone concentrations. Thus, aldosterone may represent an

important target for future antidepressant and anxiolytic drug development.

[Guest guest]

U need to wear your white fur coat when you see this dr tho

Sent from my iPhone

On Aug 26, 2008, at 2:42 PM, Valarie <val@...> wrote:

> Ha! I'm not crazy! But he who says PA has no symptoms is limited.

>

> Val

> _______________________

> Hormones and Behavior

> Volume 54, Issue 1, June 2008, Pages 90-97

>

> Chronic treatment with the mineralocorticoid hormone aldosterone

> results in

> increased anxiety-like behavior

>

> Natasa Hlavacova and a Jezova

> Laboratory of Pharmacological Neuroendocrinology, Institute of

> Experimental

> Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06,

> Bratislava,

> Slovakia

>

>

> References and further reading may be available for this article. To

> view

> references and further reading you must purchase

> <http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6WGC-4RWH8D1-1 & _u

> ser=

> 10 &

> _coverDate=06%2F30%2F2008 & _alid=782243165 & _rdoc=58 & _fmt=full & _orig=se

> arch &

> _cdi=

> 6819 & _sort=d & _docanchor= & view=c & _ct=4695 & _acct=C000050221 & _version

> =1 & _urlVersion=0 & _userid=10 & md5=c45cdd37aa2f76ad9746f3cc3b038b7f> this

> article.

> Abstract

> Aldosterone is the last component of the renin–angiotensin–

> aldosterone

> system inducing its peripheral effects via mineralocorticoid

> receptors (MR).

> Brain MR bind preferentially glucocorticoids. So far, the role of MR

> in

> behavioral functions has been investigated almost exclusively in

> relation to

> glucocorticoids. Recently, aldosterone itself has been linked to

> affective

> disorders. The aim of this study was to test the hypothesis that

> chronic

> elevation of circulating levels of aldosterone leads to increased

> anxiety.

> We have investigated the effects of chronic aldosterone treatment on

> (1)

> anxiety-like behavior, and (2) basal and stress-induced levels of

> selected

> hormones. Forty male Wistar rats were subcutaneously implanted with

> osmotic

> minipumps and treated with aldosterone (2 µg/100 g/day) or vehicle f

> or two

> weeks. Aldosterone concentrations in plasma showed a mild

> (approximately

> four-fold) increase at the end of two-week aldosterone treatment.

> This mild

> hyperaldosteronism resulted in a significant enhancement of anxiety as

> demonstrated by alterations in all indicators of anxiety-like behavior

> measured in the open field and elevated plus-maze tests, without

> significant

> changes in measures of general locomotor activity. Aldosterone

> treatment

> affected not only the spatiotemporal measures of anxiety, but also the

> ethological parameters related to exploration and risk assessment.

> Chronic

> treatment with aldosterone was associated with increased water

> intake and

> decreased plasma renin activity, but failed to modify basal or

> stress-induced activity of the hypothalamic–pituitary–

> adrenocortical axis.

> The results provide evidence on anxiogenic action of prolonged

> increase in

> circulating aldosterone concentrations. Thus, aldosterone may

> represent an

> important target for future antidepressant and anxiolytic drug

> development.

>

>

[Guest guest]

I know, I know, rats again. But there is little written about what we on this

board know.

Val

From: hyperaldosteronism

[mailto:hyperaldosteronism ] On Behalf Of Lowerbp2

U need to wear your white fur coat when you see this dr tho

[Guest guest]

They didn't have to torture the poor little rats, why didn't they just ask us?

 

a

From: Valarie <val@...>

Subject: Chronic treatment with the mineralocorticoid

hormone aldosterone results in increased anxiety-like behavior

hyperaldosteronism

Date: Tuesday, August 26, 2008, 3:42 PM

Ha! I'm not crazy! But he who says PA has no symptoms is limited.

Val

____________ _________ __

Hormones and Behavior

Volume 54, Issue 1, June 2008, Pages 90-97

Chronic treatment with the mineralocorticoid hormone aldosterone results in

increased anxiety-like behavior

Natasa Hlavacova and a Jezova

Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental

Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06, Bratislava,

Slovakia

References and further reading may be available for this article. To view

references and further reading you must purchase

<http://www.scienced irect.com/ science?_ ob=ArticleURL & _udi=B6WGC- 4RWH8D1-1 &

_u

ser=10 & _coverDate= 06%2F30%2F2008 & _alid=782243165 & _rdoc=58 & _fmt=full &

_orig=se

arch & _cdi=6819 & _sort=d & _ docanchor= & view=c & _ ct=4695 & _ acct=C000050221 &

_version

=1 & _urlVersion= 0 & _userid= 10 & md5=c45cdd37a a2f76ad9746f3cc3 b038b7f> this

article.

Abstract

Aldosterone is the last component of the renin–angiotensin– aldosterone

system inducing its peripheral effects via mineralocorticoid receptors (MR).

Brain MR bind preferentially glucocorticoids. So far, the role of MR in

behavioral functions has been investigated almost exclusively in relation to

glucocorticoids. Recently, aldosterone itself has been linked to affective

disorders. The aim of this study was to test the hypothesis that chronic

elevation of circulating levels of aldosterone leads to increased anxiety.

We have investigated the effects of chronic aldosterone treatment on (1)

anxiety-like behavior, and (2) basal and stress-induced levels of selected

hormones. Forty male Wistar rats were subcutaneously implanted with osmotic

minipumps and treated with aldosterone (2 µg/100 g/day) or vehicle for two

weeks. Aldosterone concentrations in plasma showed a mild (approximately

four-fold) increase at the end of two-week aldosterone treatment. This mild

hyperaldosteronism resulted in a significant enhancement of anxiety as

demonstrated by alterations in all indicators of anxiety-like behavior

measured in the open field and elevated plus-maze tests, without significant

changes in measures of general locomotor activity. Aldosterone treatment

affected not only the spatiotemporal measures of anxiety, but also the

ethological parameters related to exploration and risk assessment. Chronic

treatment with aldosterone was associated with increased water intake and

decreased plasma renin activity, but failed to modify basal or

stress-induced activity of the hypothalamic– pituitary– adrenocortical axis.

The results provide evidence on anxiogenic action of prolonged increase in

circulating aldosterone concentrations. Thus, aldosterone may represent an

important target for future antidepressant and anxiolytic drug development.

[Guest guest]

Yeah!

a, when you went off spiro for three weeks in prep for AVS, what were

you feeling when you called your primary and said you'd be dead in another

three weeks? Was it just high BP or were you feeling other things?

Val

-----Original Message-----

From: hyperaldosteronism

[mailto:hyperaldosteronism ] On Behalf Of a Hall

They didn't have to torture the poor little rats, why didn't they just ask

us?

 

a

From: Valarie <val@...>

Ha! I'm not crazy! But he who says PA has no symptoms is limited.

[Guest guest]

Val,

It wasn't for the AVS, I stayed on spiro for that. The brilliant endo that I

wasted almost a year and several hundreds of dollars with decided I should have

a salt-loading test and wanted me off it for 6 weeks. Despite the fact that

most of my aldosterone levels were high, renins were low, I had unprovoked

hypokalemia AND it was known that I had bilateral adenomas! All he could see

was that a couple of my aldosterone levels were high normal and a couple of

renins low normal. It amazes me that there are so many doctors like him who are

allowed to call themselves Endocrinologists. He did not even order my K+ levels

checked so I have no idea how low I got during the 3 weeks off spiro. All I

remember was that I could barely put one foot in front of the other. My ususal

level of tiredness was magnified about 50X. My body ached all over, I had

muscle cramps and very frequent irregular heart beats. All I could do was come

home from work, throw

something in the microwave and crawl off to bed. The final straw was when I

feel asleep sitting at the computer. It was about 5:30 PM and I was checking my

email after getting home from work. The next thing I knew my chin was bouncing

off my chest. People at work were asking me if I was ok and I was beginning to

believe that I must have something fatal to feel so bad. I burst out crying at

something very trivial during this time and that is definitely NOT me! My

Primary was suspecting Conn's and had started me on 50 mg spiro. He didn't have

much knowledge of the disease or the dose of spiro then but at least he

suspected it. The 50 mg was keeping my K+ low normal and I started feeling

better a couple of days after going back on it. Looking back on it, I should

have educated myself on PA when my Primary first suspected it and maybe I'd have

found this group then.

a

Yeah!

a, when you went off spiro for three weeks in prep for AVS, what were

you feeling when you called your primary and said you'd be dead in another

three weeks? Was it just high BP or were you feeling other things?

Val

[Guest guest]

Excellent description of the evolution of aldo after stopping spiro

Classic! sorry you had to suffer. Trust none of your D

Drs grad from u of mich

Please b sure to take my article and your description to

All of your DES

Sent from my iPhone

On Aug 26, 2008, at 6:20 PM, a Hall <shahall@...> wrote:

> Val,

> It wasn't for the AVS, I stayed on spiro for that. The brilliant

> endo that I wasted almost a year and several hundreds of dollars

> with decided I should have a salt-loading test and wanted me off it

> for 6 weeks. Despite the fact that most of my aldosterone levels

> were high, renins were low, I had unprovoked hypokalemia AND it was

> known that I had bilateral adenomas! All he could see was that a

> couple of my aldosterone levels were high normal and a couple of

> renins low normal. It amazes me that there are so many doctors like

> him who are allowed to call themselves Endocrinologists. He did not

> even order my K+ levels checked so I have no idea how low I got

> during the 3 weeks off spiro. All I remember was that I could barely

> put one foot in front of the other. My ususal level of tiredness was

> magnified about 50X. My body ached all over, I had muscle cramps and

> very frequent irregular heart beats. All I could do was come home

> from work, throw

> something in the microwave and crawl off to bed. The final straw was

> when I feel asleep sitting at the computer. It was about 5:30 PM and

> I was checking my email after getting home from work. The next thing

> I knew my chin was bouncing off my chest. People at work were asking

> me if I was ok and I was beginning to believe that I must have

> something fatal to feel so bad. I burst out crying at something very

> trivial during this time and that is definitely NOT me! My Primary

> was suspecting Conn's and had started me on 50 mg spiro. He didn't

> have much knowledge of the disease or the dose of spiro then but at

> least he suspected it. The 50 mg was keeping my K+ low normal and I

> started feeling better a couple of days after going back on it.

> Looking back on it, I should have educated myself on PA when my

> Primary first suspected it and maybe I'd have found this group then.

>

> a

>

> Yeah!

>

> a, when you went off spiro for three weeks in prep for AVS,

> what were

> you feeling when you called your primary and said you'd be dead in

> another

> three weeks? Was it just high BP or were you feeling other things?

>

> Val

>

>