Another Resveratrol Anti-Aging Breakthrough

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Another Resveratrol Anti-Aging Breakthrough

Saturday, November 29, 2008

Byron s, CCN

http://www.wellnessresources.com/health/articles/another_resveratrol_anti_aging_\

breakthrough/?source=Email & camp=news120108

A new mechanism has been identified that explains one novel way that

resveratrol not only helps prevent aging but may help reverse it. It

involves a unique way in which the resveratrol-activated SIRT1 guards your

DNA. In the new study the researchers state: " We see here, through a

proof-of-principal demonstration, that elements of aging can be reversed. "

The researchers expanded on their earlier work with yeast and found that a

novel mechanism also applies to mammals. One of SIRT1's duties is to stand

guard over gene switches to ensure only those that are relevant to healthy

function of that type of cell are activated. When a cell is stressed by

toxins, free radicals, germs, UV radiation, inflammation, or something else

it can cause DNA damage. Under these circumstances SIRT1 leaves its guard

post and helps out with emergency DNA repair. While SIRT1 is gone from

guard duty genes can activate that should not, causing cell dysregulation

and aging. In a healthy situation, once SIRT1 finishes DNA repair then it

returns to guard duty and re-establishes proper gene regulation that may

have gone awry while it was gone.

The researchers proved that one common theme of aging is that SIRT1 is not

on guard duty adequately. Aging is invariably accompanied by too many wrong

gene signals activated too often. The greater the DNA damage the faster the

aging, due in no small part to the improper gene activation (not necessarily

the DNA damage itself).

The researchers also found that giving resveratrol to mice that lacked

adequate SIRT1 for proper guard duty restored their gene signals to healthy

and reversed aging. This is a major breakthrough in anti-aging science.

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