Mangosteen and Cancer

[Guest guest]

Anyone reading the post on Mangosteen should also read the Newsletter sent

by Ralph Moss. Moss does more than critique the medical Profession, he

critiques anything regarding cancer in his Moss Reports.

His 05/09/04 letter was written about Mangosteen and wasn't as flattering as

those most likely marketing or sending out information out of an honest

effort to help someone.

With so many protocols and products out there we need help in fathoming what

might be useful.

Joe C.

[Guest guest]

Mangosteen and Cancer pub. By sound concepts.

MANGOSTEEN and CANCER

J. Frederic Templeman, MD: Cancer is a blanket term covering a

variety of disorders with the common element of abnormal,

uncontrolled cell growth that will not stop on its own. Under

normal conditions, cell growth is strictly controlled with cell

birth equaling cell death so that the total number of cells in the

body remains relatively constant. At times, abnormal growth that is

not cancerous can occur. We still call the abnormal tissue

a " tumor " but it is benign and not malignant (cancerous). In this

pamphlet, I will be dealing only with cancer.

The mechanism which stimulates cells to divide and multiply (when

repair or replacement work is needed in the body) and then turns

them off afterwards is under the control of genes contained in the

chromosomes of the nucleus. These genes, which are composed of DNA,

can be thought of as the policemen of cell society. The nucleus of

the cell would be the control center of all regulatory activity.

In the nucleus, the DNA, like the hard drive of a computer, contains

all the programming for the body. When it is damaged by free

radicals, for example, it can become corrupted or scarred. This

damage is called mutation and it is the critical event that leads to

cancer. A mutation can be seen as the failure of a gene to perform

its duty. (Watch for the change here). Using the policeman

comparison again, mutation becomes possible only if the policeman

(gene) is corrupted by criminal elements and becomes a criminal

himself or if he is asleep on the job and does nothing while

damaging changes occur around him.

Continuing the analogy, disease, viruses, environmental pollutants,

dangerous foods etc. can be seen as criminal elements whose purpose

is to disrupt the society of cells in our body and then profit from

the chaos and damage that results. These criminal elements have

agents working for them called free radicals. Free radicals charge

around the body like madmen armed with automatic weapons which they

fire all around them damaging healthy cells. They then steal

electrons left unprotected by their attack. Their primary target is

the DNA in the nucleus, the command center of the cell where they

can inflict the greatest damage.

A prominent free radical researcher Dr. Bruce Ames estimates that

the DNA material in every one of the trillions of cells in our body

receives about ten thousand hits from free radicals everyday! To

prevent a breach of the body's defenses in the face of an attack of

such magnitude requires the concerted efforts of all the agents of

the immune system, which can be seen as the armed forces of the

body, along with the collaboration of the policemen or the gene

regulatory mechanism.

When, despite the body's best efforts, a breach of our defenses

occurs, a tumor forms. Like a city captured by enemy forces, the

tumor becomes a stronghold that has multiple defense mechanisms with

which it resists the continued attacks of the immune system. Within

the stronghold, tumor viruses and deranged cells proliferate and are

sent out like secret agents to corrupt (infect) healthy cells

elsewhere. The cells of the tumor itself grow without the

restrictions that govern normal cells and, almost immediately,

become the fastest growing tissue in the body. As they grow

rapidly, they steal food and energy needed by healthy cells. For

this reason, cancer patients may appear starved and wasted (a

medical term called cachexia). Tumors cause pain by becoming large

enough to press on nerves or other pain sensitive structures. They

can block ducts or intestines causing severe bodily dysfunction.

They often completely take over whole organs, i.e. the liver or

lungs, crowding out functioning cells and leading to organ death.

Many cancers spread or metastasize to other areas of the body

(remember the " secret agent " tumor viruses?), invading organs far

from where they originally started. In contrast, most normal cells

are anchored in place. Because of this mobility, a breast cancer

cell can make its way to the brain, for example, and start another

tumor. When metastases (distant sites of cancer invasion) are

present, the enemy has already developed several strongholds

throughout the body. If the cancer is unchecked, death is the

inevitable outcome.

Standard cancer intervention centers on the surgical excision of

tumors and/or their destruction by radiation or chemotherapy.

Immuno-stimulative therapies, although rare, also exist.

Unfortunately, most of these interventions also damage normal

healthy tissue as well. For example, chemotherapy indiscriminately

destroys all rapidly-growing cells (sometimes by producing large

numbers of free radicals). Therefore, while it targets cancer, it

also destroys normal hair follicles, blood-producing bone marrow

cells, the cells which line the intestine and, most importantly, the

protective cells of the immune system which are essential to the

prevention of infection. The challenge of therapy is to destroy the

cancer before the chemotherapy or other treatment mortally weakens

the patient.

It is ironic to consider that the radiation and the free radical

attacks of chemotherapy that are used to destroy the tumors may

resemble the process that caused the cancer in the first place!

While not commonly recognized by most doctors, food supplements can

be valuable adjuncts o standard cancer therapy. No compelling

evidence has emerged to prove that they interfere with chemotherapy

although some researchers have examined this possibility.

Additionally, unlike medicines which do nothing to prevent cancer,

food supplements are extremely effective at regulating the cellular

dysfunction that leads to mutation and cancer. The expression, " An

ounce of medicine is worth a pound of cure " was never more

applicable!

Mangosteen's xanthones (phytoceuticals found only in this plant)

have proven ability to destroy cancerous cells, and in fact,

Garcinone E, an xanthone, was more effective than five commonly used

chemotherapy agents for stomach, lung and liver cancer (vincristine,

mitoxantrone, 5-flourouracil, cisplastin and methotrexate) in a

recent well-designed in vitro study.

In order to understand the several means by which mangosteen

phytoceuticals protect us from cancer, I miust return for a mment to

the most accepted theory of cancer development.

Step one The genetic material (DNA) of the cell is damaged by

free radicals from pollution, metabolic residues and infection or

disease and MUTATION occurs.

Step two The damaged cell divides and begins to disobey the

rules of normal cell replication. Cancer now exist.

Step three Carcinogens then promote the development and

progression of the tumor often leading to metastases.

Where do the mangosteen phytoceuticals intervene in this deadly

process? Well, the answer is that in addition to being anti-tumor

agents when cancer already exists, they prevent and arrest cancerous

change at every step.

It is quite impossible for us to avoid exposure to carcinogens and

the free radical assaults that follow, but the antioxidants and

other active phytoceuticals in the mangosteen can provide protection

from critical cell damage. They do this by regulating gene

expression and repairing free radical damage. In other words, they

protect against cancer by helping both the policemen (genes) and the

armed forces of the body (immune system) to become more efficient at

preventing mutation in the first place.

Additionally, the biologically active elements in the mangosteen

impede the promotion and the progression of cancer when DNA damage

does occur. Finally, they attack existing tumors.

A word of caution. I've described previously in " Mangosteen, the X-

factor " the differences between medicines and phytoceuticals.

Medicines are like sledgehammers compared to the rubber mallets of

the phytoceuticals. Do not stop any cancer treatment to replace it

with mangosteen. The phytoceuticals will do their work even in the

presence of other cancer therapies. Remember also that there is no

conclusive evidence that the use of phytoceuticalsimpairs the

efficacy of chemotherapy.

Finally, while it is exciting to realize what the mangosteen

phytoceuticals will do in the area of cancer treatment, it is far

more important to prevent the development of cancer in the first

place. Nothing does it better than mangosteen. Waiting until you

develop cancer in order to learn how to deal with it just isn't

smart. You may not feel the protective work it's doing in your

body, but as the years go by the results you'll experience will be

difficult to imagine. Unfortunately, many of your friends who chose

not to supplement will not be around to celebrate your good health.

healthandnutritionalsupplement/

[Guest guest]

Boy, that's some sales pitch in that last paragraph "Unfortunately many of your friends who chose not to supplement will not be around to celebrate your good health."

It seems to me that they are implying that if we don't take Mangosteen Phytocueticals, we're doomed.

I'm all for good health/eating and cancer prevention-- but THIS is a dubious claim in IMO.

LM

gmduval <gmduval@...> wrote:

Mangosteen and Cancer pub. By sound concepts.MANGOSTEEN and CANCERJ. Frederic Templeman, MD: Cancer is a blanket term covering a variety of disorders with the common element of abnormal, uncontrolled cell growth that will not stop on its own. Under normal conditions, cell growth is strictly controlled with cell birth equaling cell death so that the total number of cells in the body remains relatively constant. At times, abnormal growth that is not cancerous can occur. We still call the abnormal tissue a "tumor" but it is benign and not malignant (cancerous). In this pamphlet, I will be dealing only with cancer.The mechanism which stimulates cells to divide and multiply (when repair or replacement work is needed in the body) and then turns them off afterwards is under the control of genes contained in the

chromosomes of the nucleus. These genes, which are composed of DNA, can be thought of as the policemen of cell society. The nucleus of the cell would be the control center of all regulatory activity.In the nucleus, the DNA, like the hard drive of a computer, contains all the programming for the body. When it is damaged by free radicals, for example, it can become corrupted or scarred. This damage is called mutation and it is the critical event that leads to cancer. A mutation can be seen as the failure of a gene to perform its duty. (Watch for the change here). Using the policeman comparison again, mutation becomes possible only if the policeman (gene) is corrupted by criminal elements and becomes a criminal himself or if he is asleep on the job and does nothing while damaging changes occur around him.Continuing the analogy, disease, viruses, environmental pollutants, dangerous foods etc. can be seen as criminal

elements whose purpose is to disrupt the society of cells in our body and then profit from the chaos and damage that results. These criminal elements have agents working for them called free radicals. Free radicals charge around the body like madmen armed with automatic weapons which they fire all around them damaging healthy cells. They then steal electrons left unprotected by their attack. Their primary target is the DNA in the nucleus, the command center of the cell where they can inflict the greatest damage.A prominent free radical researcher Dr. Bruce Ames estimates that the DNA material in every one of the trillions of cells in our body receives about ten thousand hits from free radicals everyday! To prevent a breach of the body's defenses in the face of an attack of such magnitude requires the concerted efforts of all the agents of the immune system, which can be seen as the armed forces of the body, along with

the collaboration of the policemen or the gene regulatory mechanism.When, despite the body's best efforts, a breach of our defenses occurs, a tumor forms. Like a city captured by enemy forces, the tumor becomes a stronghold that has multiple defense mechanisms with which it resists the continued attacks of the immune system. Within the stronghold, tumor viruses and deranged cells proliferate and are sent out like secret agents to corrupt (infect) healthy cells elsewhere. The cells of the tumor itself grow without the restrictions that govern normal cells and, almost immediately, become the fastest growing tissue in the body. As they grow rapidly, they steal food and energy needed by healthy cells. For this reason, cancer patients may appear starved and wasted (a medical term called cachexia). Tumors cause pain by becoming large enough to press on nerves or other pain sensitive structures. They can block ducts or

intestines causing severe bodily dysfunction. They often completely take over whole organs, i.e. the liver or lungs, crowding out functioning cells and leading to organ death. Many cancers spread or metastasize to other areas of the body (remember the "secret agent" tumor viruses?), invading organs far from where they originally started. In contrast, most normal cells are anchored in place. Because of this mobility, a breast cancer cell can make its way to the brain, for example, and start another tumor. When metastases (distant sites of cancer invasion) are present, the enemy has already developed several strongholds throughout the body. If the cancer is unchecked, death is the inevitable outcome.Standard cancer intervention centers on the surgical excision of tumors and/or their destruction by radiation or chemotherapy. Immuno-stimulative therapies, although rare, also exist. Unfortunately, most of these

interventions also damage normal healthy tissue as well. For example, chemotherapy indiscriminately destroys all rapidly-growing cells (sometimes by producing large numbers of free radicals). Therefore, while it targets cancer, it also destroys normal hair follicles, blood-producing bone marrow cells, the cells which line the intestine and, most importantly, the protective cells of the immune system which are essential to the prevention of infection. The challenge of therapy is to destroy the cancer before the chemotherapy or other treatment mortally weakens the patient.It is ironic to consider that the radiation and the free radical attacks of chemotherapy that are used to destroy the tumors may resemble the process that caused the cancer in the first place!While not commonly recognized by most doctors, food supplements can be valuable adjuncts o standard cancer therapy. No compelling evidence has emerged to prove

that they interfere with chemotherapy although some researchers have examined this possibility. Additionally, unlike medicines which do nothing to prevent cancer, food supplements are extremely effective at regulating the cellular dysfunction that leads to mutation and cancer. The expression, "An ounce of medicine is worth a pound of cure" was never more applicable!Mangosteen's xanthones (phytoceuticals found only in this plant) have proven ability to destroy cancerous cells, and in fact, Garcinone E, an xanthone, was more effective than five commonly used chemotherapy agents for stomach, lung and liver cancer (vincristine, mitoxantrone, 5-flourouracil, cisplastin and methotrexate) in a recent well-designed in vitro study.In order to understand the several means by which mangosteen phytoceuticals protect us from cancer, I miust return for a mment to the most accepted theory of cancer development.Step one The

genetic material (DNA) of the cell is damaged by free radicals from pollution, metabolic residues and infection or disease and MUTATION occurs.Step two The damaged cell divides and begins to disobey the rules of normal cell replication. Cancer now exist.Step three Carcinogens then promote the development and progression of the tumor often leading to metastases. Where do the mangosteen phytoceuticals intervene in this deadly process? Well, the answer is that in addition to being anti-tumor agents when cancer already exists, they prevent and arrest cancerous change at every step.It is quite impossible for us to avoid exposure to carcinogens and the free radical assaults that follow, but the antioxidants and other active phytoceuticals in the mangosteen can provide protection from critical cell damage. They do this by regulating gene expression and repairing free radical damage. In other words, they protect

against cancer by helping both the policemen (genes) and the armed forces of the body (immune system) to become more efficient at preventing mutation in the first place.Additionally, the biologically active elements in the mangosteen impede the promotion and the progression of cancer when DNA damage does occur. Finally, they attack existing tumors.A word of caution. I've described previously in "Mangosteen, the X-factor" the differences between medicines and phytoceuticals.Medicines are like sledgehammers compared to the rubber mallets of the phytoceuticals. Do not stop any cancer treatment to replace it with mangosteen. The phytoceuticals will do their work even in the presence of other cancer therapies. Remember also that there is no conclusive evidence that the use of phytoceuticalsimpairs the efficacy of chemotherapy.Finally, while it is exciting to realize what the mangosteen phytoceuticals will do in

the area of cancer treatment, it is far more important to prevent the development of cancer in the first place. Nothing does it better than mangosteen. Waiting until you develop cancer in order to learn how to deal with it just isn't smart. You may not feel the protective work it's doing in your body, but as the years go by the results you'll experience will be difficult to imagine. Unfortunately, many of your friends who chose not to supplement will not be around to celebrate your good health.healthandnutritionalsupplement/