Guest guest Posted July 2, 2001 Report Share Posted July 2, 2001 In a message dated 07/02/2001 10:13:01 PM Eastern Daylight Time, faussettdp@... writes: << I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. >> Hi Patty: In case Dr does not reply to your post you might want to contact him yourself. Here is his website. http://www.cancer-alternatives.com/ What is the difference between cayano and methylcobalamin.? Christel Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 2, 2001 Report Share Posted July 2, 2001 In a message dated 07/02/2001 10:13:01 PM Eastern Daylight Time, faussettdp@... writes: << I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. >> Hi Patty: In case Dr does not reply to your post you might want to contact him yourself. Here is his website. http://www.cancer-alternatives.com/ What is the difference between cayano and methylcobalamin.? Christel Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 2, 2001 Report Share Posted July 2, 2001 Injectable methylcobalamin (vitamin B12) is available from this compounding pharmacy - BY DOCTOR'S PRESCRIPTION : The McGuff Company 3524 West Lake Center Drive Santa Ana, CA 92704 Phone 1-800 854-7220 (7:30 am - 5:00 pm) When ordering, ask for Glenn (or the compounding pharmacy department). First, ask for their fax number, so your doctor's office can fax the prescription. 30 cc vials: 1 mg/cc = $24.00 - plus shipping 5 mg/cc = $27.00 " 10 mg/cc = $28.65 " The best Methyl-B12 is " mix your own, " which contains no preservatives. I don't know if they sell this type, or if there is some type of preservative already added to the mix, or what the active life is, after you receive the shipment. You should ask them about this. Bill .. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 2, 2001 Report Share Posted July 2, 2001 Injectable methylcobalamin (vitamin B12) is available from this compounding pharmacy - BY DOCTOR'S PRESCRIPTION : The McGuff Company 3524 West Lake Center Drive Santa Ana, CA 92704 Phone 1-800 854-7220 (7:30 am - 5:00 pm) When ordering, ask for Glenn (or the compounding pharmacy department). First, ask for their fax number, so your doctor's office can fax the prescription. 30 cc vials: 1 mg/cc = $24.00 - plus shipping 5 mg/cc = $27.00 " 10 mg/cc = $28.65 " The best Methyl-B12 is " mix your own, " which contains no preservatives. I don't know if they sell this type, or if there is some type of preservative already added to the mix, or what the active life is, after you receive the shipment. You should ask them about this. Bill .. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 2, 2001 Report Share Posted July 2, 2001 Patty I can not find a source for it, I have tried Merit, Darby and all of the rest of the manufactures. Sorry Vitamin B12 injections > I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. Does anyone know where I can get this over the internet without prescription? I am on my last vial of cyanocobalamin, which I got in Mexico a couple years ago. I just can't get back there very soon. > This is simply Vitamin B12, but I need more than a sublingual can provide. > Any help is appreciated! > Patty > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 2, 2001 Report Share Posted July 2, 2001 Patty I can not find a source for it, I have tried Merit, Darby and all of the rest of the manufactures. Sorry Vitamin B12 injections > I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. Does anyone know where I can get this over the internet without prescription? I am on my last vial of cyanocobalamin, which I got in Mexico a couple years ago. I just can't get back there very soon. > This is simply Vitamin B12, but I need more than a sublingual can provide. > Any help is appreciated! > Patty > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 3, 2001 Report Share Posted July 3, 2001 I can only buy the cyanocobalamin. However the other is better, as for Folic acid, I buy it from either drug company along with all the others we use for the IVs Re: Vitamin B12 injections Patty I can not find a source for it, I have tried Merit, Darby and all of the rest of the manufactures. Sorry Vitamin B12 injections > I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. Does anyone know where I can get this over the internet without prescription? I am on my last vial of cyanocobalamin, which I got in Mexico a couple years ago. I just can't get back there very soon. > This is simply Vitamin B12, but I need more than a sublingual can provide. > Any help is appreciated! > Patty > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 3, 2001 Report Share Posted July 3, 2001 I can only buy the cyanocobalamin. However the other is better, as for Folic acid, I buy it from either drug company along with all the others we use for the IVs Re: Vitamin B12 injections Patty I can not find a source for it, I have tried Merit, Darby and all of the rest of the manufactures. Sorry Vitamin B12 injections > I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. Does anyone know where I can get this over the internet without prescription? I am on my last vial of cyanocobalamin, which I got in Mexico a couple years ago. I just can't get back there very soon. > This is simply Vitamin B12, but I need more than a sublingual can provide. > Any help is appreciated! > Patty > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 3, 2001 Report Share Posted July 3, 2001 I live in Calexico border to Mexicali B.C. if you send me a check or m.o. for the medicine I'll gladly will send it to you. M.D. Vitamin B12 injections I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. Does anyone know where I can get this over the internet without prescription? I am on my last vial of cyanocobalamin, which I got in Mexico a couple years ago. I just can't get back there very soon. This is simply Vitamin B12, but I need more than a sublingual can provide. Any help is appreciated! Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 3, 2001 Report Share Posted July 3, 2001 I live in Calexico border to Mexicali B.C. if you send me a check or m.o. for the medicine I'll gladly will send it to you. M.D. Vitamin B12 injections I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. Does anyone know where I can get this over the internet without prescription? I am on my last vial of cyanocobalamin, which I got in Mexico a couple years ago. I just can't get back there very soon. This is simply Vitamin B12, but I need more than a sublingual can provide. Any help is appreciated! Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 3, 2001 Report Share Posted July 3, 2001 Here is the B12 injection... it contains the syringes, needles and it is contained in an ampoule multi dosis. ----------------------- Pasted from the PDRS named in Mexico PLM--------------------------------------------------- TIAMINAL* B12 50,000 Solucion inyectable Vitaminico Cianocobalamina, tiamina y lidocaina) FORMA FARMACEUTICA Y FORMULACION: Cada ml de SOLUCION INYECTABLE contiene: Vitamina B12 (cianocobalamina) 5,000 mcg Vitamina B1 (clorhidrato de tiamina 33,300 U.I.) 100 mg Clorhidrato de lidocaina 1 mg Vehiculo, c.b.p. 1 ml. INDICACIONES TERAPEUTICAS: TIAMINAL* B12 50,000 esta indicado en la prevencion y/o tratamiento de la deficiencia por aumento de los requerimientos diarios o por aumento del gasto metabolico de las vitaminas contenidas en su formula. Auxiliar en el manejo de radiculitis, polineuritis de etiologia alcoholica y diabetica, neuritis del embarazo, polineuritis por isoniacida, neuralgias perifericas, faciales del trigemino y herpeticas, coadyuvante en el manejo del sindrome de Korsakoff. FARMACOCINETICA Y FARMACODINAMIA EN HUMANOS: Las vitaminas B1 y B12 intervienen en el metabolismo de todas las celulas del organismo, destacandose su actividad principalmente sobre las celulas del sistema nervioso, de ahi que se les denominen comunmente vitaminas neurotropas. La deficiencia de una de ellas son causa de alteraciones neurologicas y hematologicas; estas deficiencias en la actualidad se presentan en forma multiple, predominando una de ellas en la expresion clinica, por ello se hace necesario la combinacion vitaminica; en la combinacion de ellas no se busca ni se tiene potencializacion farmacologica, se justifica por la deficiencia vitaminica multiple. Vitamina B12: Hoy se sabe que la vitamina B12 corresponde a una serie de sustancias denominadas cobalaminas que poseen cobalto en su molecula. A su vez, las cobalaminas derivan de una sustancia fundamental, la cobamida que contiene cobalto trivalente. La vitamina B12 propiamente dicha es la cianocobalamina y posee un grupo cianuro unido al cobalto, mientras que la hidroxocobalamina posee un grupo hidroxilo unido al cobalto; tanto la cianocobalamina como la hidroxocobalamina poseen la misma actividad terapeutica. En la naturaleza, la unica fuente original se encuentra en ciertos microorganismos que crecen en el suelo, el agua o el lumen intestinal. El hombre depende de fuentes exogenas de vitamina B12 ya que lo que el sintetiza en el colon no esta disponible para ser absorbida, por lo tanto la obtiene al ingerir subproductos animales en su dieta diaria. Aunque es mucho lo que ya se sabe de las vias metabolicas intracelulares en las que participa esta vitamina, no se ha determinado el papel metabolico exacto de la vitamina B12,, pero se sabe que es esencial para el crecimiento y replicacion celular en el metabolismo de lipidos, la formacion de ADN y la maduracion normal de los eritrocitos. Tambien se sabe que se requiere vitamina B12 para la sintesis de mielina y mantener la integridad del tejido neuronal. La cianocobalamina y la hidroxocobalamina se absorben facilmente cuando se administran por via intramuscular y subcutanea; cuando es por via bucal su absorcion en individuos normales es de 70%; para que ocurra la absorcion en el ileon, es necesario la presencia del " factor intrinseco gastrico de Castle " , que al combinarse con la vitamina B12 permite su absorcion en forma de un complejo: factor intrinseco-B12. Una vez absorbida la vitamina B12 pasa al plasma sanguineo y su nivel normalmente es de 15 a 100 ng/dl, es decir, 150 a 1,000 pg/ml en 4 a 5 horas y declina en el transcurso de 72 horas. En el plasma se encuentra entre 80 a 85% combinada con las globulinas: transcobalamina I y II, esta ultima es la que sirve especialmente como transporte de la vitamina B12 a los tejidos. Tanto la cianocobalamina como la hidroxocobalamina se transforman en las coenzimas metilcobalamina y 5'-desoxiadenosilcobalamina que son esenciales para el crecimiento, la replicacion celular y el mantenimiento de la vaina de mielina de todo el sistema nervioso. La metilcobalamina se requiere para la formacion de metionina y su derivado la S-adenosil-metionina a partir de la hemocisteina. Este proceso tiene por fin regenerar continuamente el tetrahidrofolato que es indispensable para la sintesis de las purinas y pirimidinas, partes esenciales en la sintesis del acido desoxirribonucleico (ADN) indispensable para una eritropoyesis y trofismo normales de las celulas epiteliales. En presencia de una deficiencia de vitamina B12, la sintesis reducida de metionina y de S-adenosil-metionina interfiere con la biosintesis proteica, con numerosas reacciones de metilacion y con la sintesis de poliaminas; ademas, la actividad de la metilenotetrahidrofolato-reductasa aumenta, lo que determina que los folatos intracelulares se dirijan a los depositos de metiltetrahidrofolato, el cual es atrapado a falta de sustrato; estos fenomenos generan una base para el desarrollo de anemia megaloblastica por deficiencia de vitamina B12. La prevision insuficiente de vitamina B12, la replicacion de ADN, se hace muy anormal; el defecto de replicacion cromosomica produce incapacidad por parte de las celulas de maduracion y completar las divisiones nucleares en tanto que la maduracion citoplasmatica continua en forma relativamente normal. Esto lleva a la produccion de celulas morfologicamente anormales o a la muerte de las celulas durante la fase de maduracion, fenomeno llamado " hematopoyesis ineficiente " . Clinicamente esta anomalia se denomina anemia megaloblastica macrocitica como la anemia perniciosa. La 5'-desoxiadenosilcobalamina es importante en la transformacion (isomerizacion) de la metilmalonil-coenzima A en succinilcoenzima A producida por la enzima metilmalonilcoenzima A-mutasa con intervencion de la 5'-desoxiadenosilcobalamina, aunado a una deficiencia de metionina sintetasa y al bloqueo de la conversion de metionina a S-adenosil-metionina. Normalmente la metilmalonilcoenzima A procede de la propionilcoenzima A que es el metabolito principal de degradacion de los acidos grasos con numero impar de carbonos; la formacion de la succinilcoenzima A con intervencion de la 5'-desoxiadenosilcobalamina hace posible la metabolizacion de los citados acidos grasos a traves del ciclo tricarboxilico, ya sea a su oxidacion final o bien en la sintesis de acidos grasos de la mielina, lipoproteina indispensable para conservar la integridad del sistema nervioso. Una deficiencia de la vitamina B12 produce danos, incluso de caracter irreversible al sistema nervioso, se presenta progresiva hinchazon de las neuronas mielinicas, desmielinizacion y muerte celular en medula espinal y corteza cerebral. Esto causa gran variedad de signos y sintomas neurologicos, incluyendo parestesias de manos y pies, disminucion de la sensacion de vibracion y posicion con la consiguiente perdida del equilibrio, disminucion de reflejos tendinosos profundos, y en etapas posteriores perdida de la memoria, confusion, depresion, delirio, alucinaciones, sicosis franca y hasta perdida de la vision central. La vitamina B12 se elimina principalmente por el rinon en forma libre, ocurriendo la maxima eliminacion dentro de las primeras 8 horas postadministracion. La fraccion excretada esta en relacion con la dosis administrada, siendo de alrededor del 10% con 50 mcg de cianocobalamina por via intramuscular y de 85% con 100 mcg de hidroxocobalamina en 48 a 72 horas; la excrecion urinaria en 72 horas es de alrededor del 60%. La vida media de la vitamina B12 es de 5 dias. Una escasa cantidad se excreta con la leche materna. Alrededor de 1 a 3 mcg se elimina por via biliar, un poco mas del 50% se reabsorbe por el circuito enterohepatico. Vitamina B1: Tiamina: Las reservas de tiamina en los tejidos son escasas y no hay pruebas de que la tiamina sintetizada por bacterias intestinales represente una fuente aprovechable de esta, la ingestion diaria insuficiente es la causa principal de la deficiencia de tiamina. La tiamina en el organismo se transforma en una coenzima, el pirofosfato de tiamina, que es la forma activa, tambien conocida como cocarboxilasa. Se sabe que el pirofosfato de tiamina interviene en 24 diferentes reacciones bioquimicas, destacandose su papel fundamental en el metabolismo de los carbohidratos, cuya transformacion quimica se produce por accion enzimatica. Asimismo la tiamina desempena un importante papel en los mecanismos relacionados con la conduccion nerviosa (interviene en la formacion de mielina) de los nervios perifericos y en la transmision neuromuscular, ya que interviene en la sintesis de la acetilcolina (mediador quimico neuronal). En el metabolismo de los hidratos de carbono, las transformaciones quimicas se producen por accion enzimatica; entre ellas la carboxilasa que esta constituida por la apocarboxilasa y el pirofosfato de tiamina. Dicho sistema enzimatico provoca la descarboxilacion de los alfacetoacidos que intervienen en el metabolismo de los carbohidratos que entran en el ciclo de Krebs, en primer lugar el acido piruvico y el acido alfa-cetoglutarico. La descarboxilacion del acido piruvico pasa por las etapas de piruvato activo y acetaldehido activo y finalmente mediante la intervencion del acido tioctico o acido lipoico se llega a la acetilacion de la coenzima A para producir la acetilcoenzima A, sustancia de gran importancia biologica en el metabolismo oxidativo de los carbohidratos, especialmente en el ciclo de Krebs; en la misma forma el acido alfa-cetoglutarico (metabolito importante en el citado ciclo de Krebs) es transformado en succinato activo y luego en acido succinico, pivote fundamental en dicho ciclo. La tiamina se absorbe facil y completamente cuando se administra por via subcutanea e intramuscular, no asi por via bucal, perdiendose entre el 20 y 75% en las heces. Absorbida la tiamina pasa a la sangre alrededor de 0.06 a 6.0 mcg/dl. Se almacena principalmente en higado, cerebro, rinon y corazon en forma de pirofosfato de tiamina. El pirofosfato de tiamina se destruye parcialmente en el organismo y el resto se excreta. Del 20 al 40% de la dosis dada se excreta con la orina principalmente, asi como en pequenas cantidades con el sudor y la leche. Esta eliminacion depende de la dosis y del estado de deficiencia del organismo, si tal es el caso, el organismo retiene cantidades importantes de tiamina. Se comprende pues que una deficiencia de tiamina ocasionara deficiencia en la oxidacion de los carbohidratos, que conlleve a trastornos funcionales de diversos tejidos, especialmente en el corazon y sobre todo en el sistema nervioso, cuyo metabolismo depende casi exclusivamente del consumo de glucosa; ademas a nivel de los nervios mielinicos, se presentan alteraciones tanto en la conduccion como en la velocidad de conduccion, debido a una desmielinizacion que ocasiona las neuritis y polineuritis del diabetico, del alcoholico y del embarazo. CONTRAINDICACIONES: Personas hipersensibles a los componentes de la formula, asi como hipersensibilidad al cobalto o cianuro y en la policitemia vera. PRECAUCIONES O RESTRICCIONES DE USO DURANTE EL EMBARAZO Y LA LACTANCIA: Estudios en animales y mujeres embarazadas no han demostrado efecto nocivo para la madre ni el feto. Las 2 vitaminas se han encontrado en muy pequenas cantidades en la leche materna. Por lo tanto su uso en mujeres embarazadas y en periodo de lactancia queda a criterio del medico tratante. REACCIONES SECUNDARIAS Y ADVERSAS: En personas hipersensibles a la tiamina y/o cianocobalamina, puede provocar reacciones de hipersensibilidad o alergia y, en algunas, shock anafilactico. Por su contenido de tiamina, se puede presentar enrojecimiento en cara, nausea, vomito, rash y diarrea que son transitorios y no obligan a suspender el medicamento. Puede presentarse dolor en el sitio de la inyeccion. Por su contenido de vitaminas B6, se ha reportado neuropatia periferica con la administracion prolongada; a dosis altas disturbios gastrointestinales, deficiencia de acido folico, sedacion, hipotension y reacciones dermicas. INTERACCIONES MEDICAMENTOSAS Y DE OTRO GENERO: El cloramfenicol disminuye la respuesta hematopoyetica de la vitamina B12. La vitamina C puede inactivar a la vitamina B12. Los bloqueadores H2, el omeprazol, la colchicina, la neomicina, preparaciones de potasio de liberacion prolongada y acido aminosalicilico y sus sales, pueden disminuir la absorcion de vitamina B12. El alcohol disminuye la absorcion de la vitamina B12. Se ha reportado que la tiamina puede aumentar el efecto de los agentes bloqueadores neuromusculares, su importancia clinica es desconocida. ALTERACIONES DE PRUEBAS DE LABORATORIO: No se han reportado a la fecha. PRECAUCIONES Y RELACION CON EFECTOS DE CARCINOGENESIS, MUTAGENESIS, TERATOGENESIS Y SOBRE LA FERTILIDAD: No se han reportado anomalias en estos rubros por la administracion de este grupo de farmacos. DOSIS Y VIA DE ADMINISTRACION: Por via intramuscular profunda se administran 1-2 ml diarios o cada 2 a 3 dias, segun la intensidad y evolucion del cuadro clinico. SOBREDOSIFICACION O INGESTA ACCIDENTAL: MANIFESTACIONES Y MANEJO (ANTIDOTOS): Respecto a la tiamina y a la cianocobalamina o hidroxocobalamina no hay peligro por una sobredosificacion. PRESENTACION: Caja con 1 frasco ampula de 10 ml, 5 jeringas de 3 ml y 5 agujas esteriles desechables. RECOMENDACIONES PARA EL ALMACENAMIENTO: Mantengase en lugar fresco y seco. Protejanse las ampolletas de la luz. LEYENDAS DE PROTECCION: Literatura exclusiva para medicos. No se deje al alcance de los ninos. Su venta requiere receta medica. LABORATORIOS SILANES, S. A. de C. V. Amores Num. 1304 - 03100 Mexico, D. F. * Marca registrada Reg. Num. 42443, S. S. A. GEAR-17052/95 Vitamin B12 injections I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. Does anyone know where I can get this over the internet without prescription? I am on my last vial of cyanocobalamin, which I got in Mexico a couple years ago. --- Outgoing mail is certified Virus Free. Este mensaje esta certificado No virus en el. Checked by AVG anti-virus system (http://www.grisoft.com). Version: 6.0.256 / Virus Database: 129 - Release Date: 5/31/2001 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 3, 2001 Report Share Posted July 3, 2001 Hydroxycobalamin is the best and longest lasting. You need a prescription for any injectable. Physiologics brand of B12 sub-lingual spray (Vitamin B12 Liposome) is as good as the shot, says Dr. in his newsletter. jp Vitamin B12 injections I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. Does anyone know where I can get this over the internet without prescription? I am on my last vial of cyanocobalamin, which I got in Mexico a couple years ago. I just can't get back there very soon. This is simply Vitamin B12, but I need more than a sublingual can provide. Any help is appreciated! Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 3, 2001 Report Share Posted July 3, 2001 Hydroxycobalamin is the best and longest lasting. You need a prescription for any injectable. Physiologics brand of B12 sub-lingual spray (Vitamin B12 Liposome) is as good as the shot, says Dr. in his newsletter. jp Vitamin B12 injections I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. Does anyone know where I can get this over the internet without prescription? I am on my last vial of cyanocobalamin, which I got in Mexico a couple years ago. I just can't get back there very soon. This is simply Vitamin B12, but I need more than a sublingual can provide. Any help is appreciated! Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 3, 2001 Report Share Posted July 3, 2001 Dr : I am interested in purchasing the B12 for injections. How much and to which address! Thanks, Sara ------------------------------------ ** It's ALL good ! ** ------------------------------------ Vitamin B12 injections I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. Does anyone know where I can get this over the internet without prescription? I am on my last vial of cyanocobalamin, which I got in Mexico a couple years ago. I just can't get back there very soon. This is simply Vitamin B12, but I need more than a sublingual can provide. Any help is appreciated! Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 3, 2001 Report Share Posted July 3, 2001 Dr : I am interested in purchasing the B12 for injections. How much and to which address! Thanks, Sara ------------------------------------ ** It's ALL good ! ** ------------------------------------ Vitamin B12 injections I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. Does anyone know where I can get this over the internet without prescription? I am on my last vial of cyanocobalamin, which I got in Mexico a couple years ago. I just can't get back there very soon. This is simply Vitamin B12, but I need more than a sublingual can provide. Any help is appreciated! Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 3, 2001 Report Share Posted July 3, 2001 Dr : I am interested in purchasing the B12 for injections. How much and to which address! Thanks, Sara ------------------------------------ ** It's ALL good ! ** ------------------------------------ Vitamin B12 injections I am looking for a source of preferably methylcobalamin for injection, but if I can't get that, I would take cyanocobalamin. Does anyone know where I can get this over the internet without prescription? I am on my last vial of cyanocobalamin, which I got in Mexico a couple years ago. I just can't get back there very soon. This is simply Vitamin B12, but I need more than a sublingual can provide. Any help is appreciated! Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 4, 2001 Report Share Posted July 4, 2001 > >I am interested in purchasing the B12 for injections. How much and to >which address! >Thanks, I have used tons of vitamins and minerals over my lifetime, but never worried about iron and B12. What am I missing? Why do people need these injections? Wayne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 4, 2001 Report Share Posted July 4, 2001 > >I am interested in purchasing the B12 for injections. How much and to >which address! >Thanks, I have used tons of vitamins and minerals over my lifetime, but never worried about iron and B12. What am I missing? Why do people need these injections? Wayne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 4, 2001 Report Share Posted July 4, 2001 > >I am interested in purchasing the B12 for injections. How much and to >which address! >Thanks, I have used tons of vitamins and minerals over my lifetime, but never worried about iron and B12. What am I missing? Why do people need these injections? Wayne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 4, 2001 Report Share Posted July 4, 2001 Wayne wrote: > >I have used tons of vitamins and minerals over my lifetime, >but never worried about iron and B12. > >What am I missing? Why do people need these injections? Low iron (anemia) may be caused by a vitamin B12 deficiency, but that's the tip of the iceberg. Do a MedLine search on the vitamin B12 " keyword list " shown below to get a real education. You will find hundreds of distinct reasons why vitamin B12 (the largest of all vitamin molecules) is frequently difficult to assimilate and /or utilize -- everything from several genetic " inborn errors of metabolism, " to intestinal disorders, to dysbiosis, to mineral and toxin interference, to vitamin B12 analog interference, to metabolic disorders or required binding-protein deficiency or blockage, including autoimmune. There are many, probably hundreds of large and very technical biomedical books written on the subject. In other words you're missing very, very much. First, an outline of the symptoms and causes of B12 deficiency: ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ from: NEUROMUSCULAR DISEASE CENTER Washington University School of Medicine, St. Louis, MO --------------------------------------------------------- http://www.neuro.wustl.edu/neuromuscular/index.html http://www.neuro.wustl.edu/neuromuscular/nother/vitamin.htm#b12 Vitamin-related syndromes excerpt: 6. Vitamin B12 (cobalamin) deficiency Clinical features Polyneuropathy Sensory Early paresthesias Loss especially of large fiber modalities Distal Motor: Later in course; Distal Reflexes Tendon: Reduced or absent at ankles Plantar: Upgoing Autonomic: Postural hypotension CNS Spinal cord Major cause of sensory & motor disability Posterior column fiber loss Spasticity in legs Cortical function Cognitive impairment in adults: Leukoencephalopathy on MRI Mental retardation or encephalopathy in childhood syndromes Anemia: Megaloblastic; Due to reduced DNA synthesis Gastrointestinal: Glossitis; Diarrhea Causes of B12 deficiency: Normal body stores last 3 to 4 years Gastrointestinal malabsorption Deficient intrinsic factor production Post-gastrectomy Antibody vs parietal cells No digestion of cobalamin-R-binder complex Pancreatic insufficiency Consumption of cobalamin in GI tract Intestinal bacterial overgrowth Poor absorption by distal ileum Sprue-related disorders Autosomal recessive disorders Anemia; Proteinuria; Juvenile onset Dietary inadequacy in vegetarians Sources: Meat & dairy products Congenital disorders of B12 binding proteins Vitamin B12 R-binding protein deficiency Neurological B12 deficiency syndromes in adults Gastric intrinsic factor deficiency Congenital anemia & jaundice Transcobolamin II deficiency Megaloblastic anemia; Diarrhea; Immunodeficiency; Mental retardation Abnormalities of synthesis of active forms of B12 Methylcobalamin deficiency, types E and G Neurological (CNS) & hematological B12 deficiency syndromes in children Adenosylcobalamin deficiency Episodic ketoacidosis; Encephalopathy; Neutropenia; Osteoporosis Combined methylcobalamin & adenosylcobalamin deficiency Types I and II Mental retardation; anemia; ± myelopathy in slowly progressive cases Abnormal release of B12 from lysosomes Testing Low serum B12 Clinically significant: < 100 pg/ml Suspicious: < 200 pg/ml High serum homocysteine & methymalonic acid Confirm biological significance of low B12 levels Treatment: 1 mg i.m. q 3 months ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ MedLine Cobalamin (vitamin B12) keyword list : Vitamin B12 (B-12) (B 12) Vit. B12 (VB12) (V.B12) Cyanocobalamin <-- Biologically inactive, and (CN-Cbl) (CNCbl) contained in multi-vitamins. Biologically active Coenzyme B12's - listed below : AdenosylCobalamin (Ado-Cbl) (AdoCbl) . Adocobalamin . Deoxyadenosylcobalamin . Dibencozide . Dimethylbenzimide . Indusil . JABA B12 . Tridocemine AquaCobalamin (AqCbl) (vitamin B12b) AquoCobalamin (AqCbl) (vitamin B12b) HydroxoCobalamin (OH-Cbl) (vitamin B12a) HydroxyCobalamin (OH-Cbl) (vitamin B12a) Methylcobalamin (Me-B12) (MeCbl) (MB12) . Methyl cobalamin . Methylobalamin . Methylcobalamine . MeCobalamin . MeCobalamine . CH3-B12 (CH3B12) (CH3Cbl) . Methyl B12 . Methyl B-12 . Methyl B 12 . Methyl Vitamin B12 . MethylCoenzyme B12 . Methylepicobalamin . Co-methyl cobalamin . Algobaz . Mecobal . Methylcobaz . Methylcobal NitritCobalamin (vitamin B12c) NitroCobalamin (vitamin B12c) Other, less common Coenzyme B12's : AlkylCobalamin DeuteroMethylcobalamin FluorAlkylcobalamin FluoroMethylcobalamin OrganoCobalamin SulphitoCobalamin SuperoxoCobalamin Cobalamin 5'-Phosphate Required Cobalamin Binding Proteins : . Intrinsic Factor . Transcobalamin . Haptocorrin Cobalamin variants (often block active cobalamin) : . Analogs . Analogues .. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 4, 2001 Report Share Posted July 4, 2001 Wayne wrote: > >I have used tons of vitamins and minerals over my lifetime, >but never worried about iron and B12. > >What am I missing? Why do people need these injections? Low iron (anemia) may be caused by a vitamin B12 deficiency, but that's the tip of the iceberg. Do a MedLine search on the vitamin B12 " keyword list " shown below to get a real education. You will find hundreds of distinct reasons why vitamin B12 (the largest of all vitamin molecules) is frequently difficult to assimilate and /or utilize -- everything from several genetic " inborn errors of metabolism, " to intestinal disorders, to dysbiosis, to mineral and toxin interference, to vitamin B12 analog interference, to metabolic disorders or required binding-protein deficiency or blockage, including autoimmune. There are many, probably hundreds of large and very technical biomedical books written on the subject. In other words you're missing very, very much. First, an outline of the symptoms and causes of B12 deficiency: ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ from: NEUROMUSCULAR DISEASE CENTER Washington University School of Medicine, St. Louis, MO --------------------------------------------------------- http://www.neuro.wustl.edu/neuromuscular/index.html http://www.neuro.wustl.edu/neuromuscular/nother/vitamin.htm#b12 Vitamin-related syndromes excerpt: 6. Vitamin B12 (cobalamin) deficiency Clinical features Polyneuropathy Sensory Early paresthesias Loss especially of large fiber modalities Distal Motor: Later in course; Distal Reflexes Tendon: Reduced or absent at ankles Plantar: Upgoing Autonomic: Postural hypotension CNS Spinal cord Major cause of sensory & motor disability Posterior column fiber loss Spasticity in legs Cortical function Cognitive impairment in adults: Leukoencephalopathy on MRI Mental retardation or encephalopathy in childhood syndromes Anemia: Megaloblastic; Due to reduced DNA synthesis Gastrointestinal: Glossitis; Diarrhea Causes of B12 deficiency: Normal body stores last 3 to 4 years Gastrointestinal malabsorption Deficient intrinsic factor production Post-gastrectomy Antibody vs parietal cells No digestion of cobalamin-R-binder complex Pancreatic insufficiency Consumption of cobalamin in GI tract Intestinal bacterial overgrowth Poor absorption by distal ileum Sprue-related disorders Autosomal recessive disorders Anemia; Proteinuria; Juvenile onset Dietary inadequacy in vegetarians Sources: Meat & dairy products Congenital disorders of B12 binding proteins Vitamin B12 R-binding protein deficiency Neurological B12 deficiency syndromes in adults Gastric intrinsic factor deficiency Congenital anemia & jaundice Transcobolamin II deficiency Megaloblastic anemia; Diarrhea; Immunodeficiency; Mental retardation Abnormalities of synthesis of active forms of B12 Methylcobalamin deficiency, types E and G Neurological (CNS) & hematological B12 deficiency syndromes in children Adenosylcobalamin deficiency Episodic ketoacidosis; Encephalopathy; Neutropenia; Osteoporosis Combined methylcobalamin & adenosylcobalamin deficiency Types I and II Mental retardation; anemia; ± myelopathy in slowly progressive cases Abnormal release of B12 from lysosomes Testing Low serum B12 Clinically significant: < 100 pg/ml Suspicious: < 200 pg/ml High serum homocysteine & methymalonic acid Confirm biological significance of low B12 levels Treatment: 1 mg i.m. q 3 months ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ MedLine Cobalamin (vitamin B12) keyword list : Vitamin B12 (B-12) (B 12) Vit. B12 (VB12) (V.B12) Cyanocobalamin <-- Biologically inactive, and (CN-Cbl) (CNCbl) contained in multi-vitamins. Biologically active Coenzyme B12's - listed below : AdenosylCobalamin (Ado-Cbl) (AdoCbl) . Adocobalamin . Deoxyadenosylcobalamin . Dibencozide . Dimethylbenzimide . Indusil . JABA B12 . Tridocemine AquaCobalamin (AqCbl) (vitamin B12b) AquoCobalamin (AqCbl) (vitamin B12b) HydroxoCobalamin (OH-Cbl) (vitamin B12a) HydroxyCobalamin (OH-Cbl) (vitamin B12a) Methylcobalamin (Me-B12) (MeCbl) (MB12) . Methyl cobalamin . Methylobalamin . Methylcobalamine . MeCobalamin . MeCobalamine . CH3-B12 (CH3B12) (CH3Cbl) . Methyl B12 . Methyl B-12 . Methyl B 12 . Methyl Vitamin B12 . MethylCoenzyme B12 . Methylepicobalamin . Co-methyl cobalamin . Algobaz . Mecobal . Methylcobaz . Methylcobal NitritCobalamin (vitamin B12c) NitroCobalamin (vitamin B12c) Other, less common Coenzyme B12's : AlkylCobalamin DeuteroMethylcobalamin FluorAlkylcobalamin FluoroMethylcobalamin OrganoCobalamin SulphitoCobalamin SuperoxoCobalamin Cobalamin 5'-Phosphate Required Cobalamin Binding Proteins : . Intrinsic Factor . Transcobalamin . Haptocorrin Cobalamin variants (often block active cobalamin) : . Analogs . Analogues .. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 8, 2008 Report Share Posted October 8, 2008 I'm new to this field, and have found this group to be very helpful! A patient's spouse today asked if vitamin B12 injections would be better than the sublingual B12? Not sure how to answer this one, or what the literature/research says about this. The program I'm working with recommends 2000mcg B12 sublingual for gastric bypass patients, and 1000mcg for lap band. Thanks in advance. Tarra MS, RD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2008 Report Share Posted October 13, 2008 It's not that one is " better " than the other. If taking the injections, it only needs to be done once a month. If taken sublingually, it needs to be taken every day, so some people have a preference based on the pros and cons of eachKerry L. Strom, RD, LDN, CNSDDietitian Educatorlin Square Hospital Centerkerry.strom@...443-777-6528This message is confidential, intended only for the named recipient(s) and may contain information that is privileged or exempt from disclosure under applicable law. If you are not the intended recipient(s), you are notified that the dissemination, distribution or copying of this message is strictly prohibited. If you received this message in error, or are not the named recipient(s), please notify the sender at either the e-mail address or phone number above and delete this e-mail from your computer. Thank you.CONFIDENTIAL: The information contained in this communication, including its attachments may contain confidential information and is intended only for the individual (s) or entity (ies) to whom it is addressed . The information contained in this communication may also be protected by legal privilege , federal law or other applicable law. If you are not the intended recipient of this communication , you are hereby notified that any distribution, dissemination or duplication of this communication is strictly prohibited. If you have received this communication in error please immediately delete and destroy all copies of this message and please immediately notify us of the error by separate communication . Thank you. Quote Link to comment Share on other sites More sharing options...
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