FW: [Chirolist-CA] Statins and diabetes

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FYI from another list serve.Dr. A Caughlin DC CAC155 NW 1st Ave Day, Or. 97845 office 541-575-1063 fax 541-575-5554> > ONLINE FIRST> Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the> Women's Health Initiative> > Annie L. Culver, BPharm; Ira S. Ockene, MD; Raji Balasubramanian, ScD;> Barbara C. Olendzki, RD, MPH; Deidre M. Sepavich, MBA;Wactawski-Wende,> PhD; JoAnn E. Manson, MD, DrPH; Yongxia Qiao, MD; Simin Liu, MD, ScD; Philip> A. Merriam, MSPH; Rahilly-Tierny, MD, MPH; Fridtjof , PhD;> S. Berger, MD, MS; Judith K. Ockene, PhD, MEd, MA; J. Curb,> MD;Yunsheng Ma, MD, PhD > > Arch Intern Med. 2012;172(2):144-152. doi:10.1001/archinternmed.2011.625> > Background This study investigates whether the incidence of new-onset> diabetes mellitus (DM) is associated with statin use among postmenopausal> women participating in the Women's Health Initiative (WHI).> > Methods The WHI recruited 161 808 postmenopausal women aged 50 to 79 years> at 40 clinical centers across the United States from 1993 to 1998 with> ongoing follow-up. The current analysis includes data through 2005. Statin> use was captured at enrollment and year 3. Incident DM status was determined> annually from enrollment. proportional hazards models were used to> estimate the risk of DM by statin use, with adjustments for propensity score> and other potential confounding factors. Subgroup analyses by> race/ethnicity, obesity status, and age group were conducted to uncover> effect modification.> > Results This investigation included 153 840 women without DM and no missing> data at baseline. At baseline, 7.04% reported taking statin medication.> There were 10 242 incident cases of self-reported DM over 1 004 466> person-years of follow-up. Statin use at baseline was associated with an> increased risk of DM (hazard ratio

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, 1.71; 95% CI, 1.61-1.83). This> association remained after adjusting for other potential confounders> (multivariate-adjusted HR, 1.48; 95% CI, 1.38-1.59) and was observed for all> types of statin medications. Subset analyses evaluating the association of> self-reported DM with longitudinal measures of statin use in 125 575 women> confirmed these findings.> > Conclusions Statin medication use in postmenopausal women is associated> with an increased risk for DM. This may be a medication class effect.> Further study by statin type and dose may reveal varying risk levels for> new-onset DM in this population.> > > > > > > > > > ********************************************************************************> "Building Chiropractic Community through enhanced communication."> > To change your preferences or unsubscribe:> http://ww3.chirolists.com/mailman/listinfo/chirolist-ca> email: Chirolist-CA-request@...?subject=unsubscribe> List options tutorial:> http://www.chirolists.com/index.cfm?nid=6> Email filters tutorial:> http://www.chirolists.com/index.cfm?nid=7> *********************************************************************************