(mentions CMT) Epidemiology of typical and atypical craniofacial neuralgias

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Neurol Sci. 2005 May;26 Suppl 2:s65-7.

Epidemiology of typical and atypical craniofacial neuralgias.

Manzoni GC, Torelli P.

Headache Centre, Section of Neurology, Department of Neuroscience,

University of Parma, Viale Gramsci 14, I-43100, Parma, Italy,

Trigeminal neuralgia (TN) has a prevalence of 0.1-0.2 per thousand

and an incidence ranging from about 4-5/100 000/year up to 20/100

000/year after age 60. The female-to-male ratio is about 3:2. A

review of several case series shows that pain is more predominant on

the right side, but the difference is not statistically significant.

TN is significantly associated with arterial hypertension, Charcot-

Marie-Tooth neuropathy, glossopharyngeal neuralgia (GN) and multiple

sclerosis. GN has an incidence of 0.7/100 000/year and

epidemiological studies have shown it to be less severe than

previously thought. Post-herpetic neuralgia has a comparable

incidence to idiopathic TN. The epidemiology of the central causes of

facial pain is still unclear, but it is known that persistent

idiopathic facial pain is a widespread, not easily manageable problem.