Mitochondrial signal transduction in accelerated wound and retinal healing by ne

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Article Abstracts

Publication: Mitochondrion Volume 4, Issues 5-6, September 2004, Pages

559-567 Title: Mitochondrial signal transduction in accelerated wound and

retinal healing by near-infrared light therapy. Authors: Eells J T,

Wong-Riley, VerHoeve J, Henry M, Buchman E V, Kane M P, Gould L J, Das R, Jett

M,

Hodgson B D, Margolis D, Whelan H T

Publication: Mitochondrion Volume 4, Issues 5-6, September 2004, Pages

559-567

Title: Mitochondrial signal transduction in accelerated wound and retinal

healing by near-infrared light therapy.

Authors: Eells J T, Wong-Riley, VerHoeve J, Henry M, Buchman E V, Kane M

P, Gould L J, Das R, Jett M, Hodgson B D, Margolis D, Whelan H T

Abstract:

Photobiomodulation by light in the red to near infrared range (630 -- 1000

nm) using low energy lasers or light-emitting diode (LED) arrays has been

shown to accelerate wound healing, improve recovery from ischemic injury in

the heart and attenuate degeneration in the injured optic nerve. Recent

evidence indicates that the therapeutic effects of red to near infrared light

result, in part, from intracellular signaling mechanisms triggered by the

interaction of NIR light with the mitochondrial photoacceptor molecule

cytochrome c oxidase. We have demonstrated that NIR-LED photo-irradiation

increases the production of cytochrome oxidase in cultured primary neurons and

reverses the reduction of cytochrome oxidase activity produced by metabolic

inhibitors. We have also shown that NIR-LED treatment prevents the

development of oral mucositis in pediatric bone marrow transplant patients.

Photobiomodulation improves wound healing in genetically diabetic mice by

upregulating genes important in the promotion of wound healing. More recent

studies

have provided evidence for the therapeutic benefit of NIR-LED treatment in

the survival and functional recovery of the retina and optic nerve in vivo

after acute injury by the mitochondrial toxin, formic acid generated in

the course of methanol intoxication. Gene discovery studies conducted using

microarray technology documented a significant upregulation of gene

expression in pathways involved in mitochondrial energy production and

antioxidant

cellular protection. These findings provide a link between the actions of

red to near infrared light on mitochondrial oxidative metabolism in vitro

and cell injury in vivo. Based on these findings and the strong evidence that

mitochondrial dysfunction is involved in the pathogenesis of numerous

diseases processes, we propose that NIR-LED photobiomodulation represents an

innovative and non-invasive therapeutic approach for the treatment of tissue

injury and disease processes in which mitochondrial dysfunction is

postulated to play a role including diabetic retinopathy, age-related macular

degeneration, Leber's hereditary optic neuropathy and Parkinson's disease.

Publication: Mitochondrion Volume 4, Issues 5-6, September 2004, Pages

559-567 Title: Mitochondrial signal transduction in accelerated wound and

retinal healing by near-infrared light therapy. Authors: Eells J T,

Wong-Riley, VerHoeve J, Henry M, Buchman E V, Kane M P, Gould L J, Das R, Jett

M,

Hodgson B D, Margolis D, Whelan H T Abstract: Photobiomodulation by light

in the red to near infrared range (630–1000 nm) using low

energy

lasers or light-emitting diode (LED) arrays has been shown to accelerate

wound healing, improve recovery from ischemic injury in the heart and attenuate

degeneration in the injured optic nerve. Recent evidence indicates that

the therapeutic effects of red to near infrared light result, in part, from

intracellular signaling mechanisms triggered by the interaction of NIR light

with the mitochondrial photoacceptor molecule cytochrome c oxidase. We

have demonstrated that NIR-LED photo-irradiation increases the production of

cytochrome oxidase in cultured primary neurons and reverses the reduction

of cytochrome oxidase activity produced by metabolic inhibitors. We have

also shown that NIR-LED treatment prevents the development of oral mucositis

in pediatric bone marrow transplant patients. Photobiomodulation improves

wound healing in genetically diabetic mice by upregulating genes important in

the promotion of wound healing. More recent studies have provided evidence

for the therapeutic benefit of NIR-LED treatment in the survival and

functional recovery of the retina and optic nerve in vivo after acute injury by

the mitochondrial toxin, formic acid generated in the course of methanol

intoxication. Gene discovery studies conducted using microarray technology

documented a significant upregulation of gene expression in pathways involved

in mitochondrial energy production and antioxidant cellular protection.

These findings provide a link between the actions of red to near infrared

light on mitochondrial oxidative metabolism in vitro and cell injury in vivo.

Based on these findings and the strong evidence that mitochondrial

dysfunction is involved in the pathogenesis of numerous diseases processes, we

propose that NIR-LED photobiomodulation represents an innovative and

non-invasive therapeutic approach for the treatment of tissue injury and

disease

processes in which mitochondrial dysfunction is postulated to play a role

including diabetic retinopathy, age-related macular degeneration, Leber's

hereditary optic neuropathy and Parkinson's disease.

Publication: Mitochondrion Volume 4, Issues 5-6, September 2004, Pages

559-567 Title: Mitochondrial signal transduction in accelerated wound and

retinal healing by near-infrared light therapy. Authors: Eells J T,

Wong-Riley, VerHoeve J, Henry M, Buchman E V, Kane M P, Gould L J, Das R, Jett

M,

Hodgson B D, Margolis D, Whelan H T Abstract: Photobiomodulation by light

in the red to near infrared range (630–1000 nm) using low

energy

lasers or light-emitting diode (LED) arrays has been shown to accelerate wound

healing, improve recovery from ischemic injury in the heart and attenuate

degeneration in the injured optic nerve. Recent evidence indicates that the

therapeutic effects of red to near infrared light result, in part, from

intracellular signaling mechanisms triggered by the interaction of NIR light

with the mitochondrial photoacceptor molecule cytochrome c oxidase. We have

demonstrated that NIR-LED photo-irradiation increases the production of

cytochrome oxidase in cultured primary neurons and reverses the reduction of

cytochrome oxidase activity produced by metabolic inhibitors. We have also

shown that NIR-LED treatment prevents the development of oral mucositis in

pediatric bone marrow transplant patients. Photobiomodulation improves

wound healing in genetically diabetic mice by upregulating genes important in

the promotion of wound healing. More recent studies have provided evidence

for the therapeutic benefit of NIR-LED treatment in the survival and

functional recovery of the retina and optic nerve in vivo after acute injury by

the mitochondrial toxin, formic acid generated in the course of methanol

intoxication. Gene discovery studies conducted using microarray technology

documented a significant upregulation of gene expression in pathways involved

in mitochondrial energy production and antioxidant cellular protection.

These findings provide a link between the actions of red to near infrared

light on mitochondrial oxidative metabolism in vitro and cell injury in vivo.

Based on these findings and the strong evidence that mitochondrial

dysfunction is involved in the pathogenesis of numerous diseases processes, we

propose that NIR-LED photobiomodulation represents an innovative and

non-invasive therapeutic approach for the treatment of tissue injury and

disease

processes in which mitochondrial dysfunction is postulated to play a role

including diabetic retinopathy, age-related macular degeneration, Leber's

hereditary optic neuropathy and Parkinson's disease.