Multiple Chemical Sensitivity: Toxicological and Sensitivity Mechanisms [ABSTRACT + FULL TEXT]

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Multiple Chemical Sensitivity: Toxicological and Sensitivity Mechanisms

Abstract

MCS has been confirmed by genetic evidence showing that six genes that influence

the metabolism of these chemicals, all influence susceptibility to MCS. It is

likely that chemicals act along these same pathways, leading to increased NMDA

activity when they trigger sensitivity responses in MCS patients.

The NO/ONOO- cycle is based on well documented individual mechanisms. The

interaction of this cycle with previously documented MCS mechanisms, notably

neural sensitization and neurogenic inflammation, explains many of the

previously unexplained properties of MCS. This overall mechanism is also

supported by physiological correlates found in MCS and related multisystem

illnesses, objectively? measurable responses to low level chemical exposure in

MCS patients, many studies of apparent animal models of MCS and also evidence

from therapeutic trials of MCS-related illnesses. Some have argued that MCS is a

psychogenic illness, but this view is completely inconsistent with this diverse

data on MCS and related illnesses and the literature claiming psychogenesis of

MCS is deeply flawed. In addition, two rare predictions that can be used to test

psychogenesis both lead to rejection of the psychogenic hypothesis.

http://www.aseq-ehaq.ca/ma_es/es_drmartinpall.php?

Full Text

plus 116 References

also discusses tests.

http://www.aseq-ehaq.ca/ma_es/pdf/MCS%20Toxicological%20and%20Sensitivity%20Mech\

anisms%20by%20%20L.%20Pall.pdf