Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs

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Alternating electric fields (TTFields) inhibitmetastatic spread of solid tumors

to the lungs

http://www.ncbi.nlm.nih.gov/pubmed/19387848

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Clin Exp Metastasis.2009;26(7):633-40. Epub 2009 Apr 23.

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Kirson ED, Giladi M, Gurvich Z, Itzhaki A, Mordechovich D, Schneiderman RS,

Wasserman Y, Ryffel B, Goldsher D, Palti Y.

Source

NovoCure Limited, Matam Advanced Technology Centre, 31905,Haifa, Israel.

Eilon@...

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Abstract

Tumor treating fields (TTFields) are low intensity,intermediate frequency,

alternating electric fields used to treat canceroustumors. This novel treatment

modality effectively inhibits the growth of solid tumorsin vivo and has shown

promise in pilot clinical trials in patients withadvanced stage solid tumors.

TTFields were tested for their potential toinhibit metastatic spread of solid

tumors to the lungs in two animal models:(1) Mice injected with malignant

melanoma cells (B16F10) into the tail vein,(2) New Zealand White rabbits

implanted with VX-2 tumors within the kidneycapsule. Mice and rabbits were

treated using two-directional TTFields at100-200 kHz. Animals were either

monitored for survival, or sacrificed forpathological and histological analysis

of the lungs. The total number of lungsurface metastases and the absolute weight

of the lungs were both significantlylower in TTFields treated mice then in sham

control mice. TTFields treated rabbitssurvived longer than sham control animals.

This extension in survival was foundto be due to an inhibition of metastatic

spread, seeding or growth in the lungsof TTFields treated rabbits compared to

controls. Histologically, extensiveperi- and intra-tumoral immune cell

infiltration was seen in TTFields treatedrabbits only. These results raise the

possibility that in addition to theirproven inhibitory effect on the growth of

solid tumors, TTFields may also haveclinical benefit in the prevention of

metastatic spread from primary tumors.

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PMID: 19387848 [PubMed - indexed for MEDLINE] PMCID: PMC2776150

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Free PMC Article