Valproate -Efficacy of fish liver oil and propolis as neuroprotective agents in

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Sections of The BioInitiative Report were updated in 2009 and published in

a special issue of the peer-reviewed journal Pathophysiology - this is

one of the studies that was added.

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Shan

Efficacy of fish liver oil and propolis as neuroprotective agents in

pilocarpine epileptic rats treated with valproate

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_http://www.sciencedirect.com/science/journal/09284680?oldURL=y_

(http://www.sciencedirect.com/science/journal/09284680?oldURL=y)

Original Research Article

Pages 287-294

Fathia Mannaa, Karima A. El-Shamy, Kamal A. El-Shaikh, Mahitab El-Kassaby

Abstract

Objective:

To evaluate the action of fish liver oil and propolis in pilocarpine

epileptic rats treated with the anticonvulsant drug valproate. Methods: Seven

groups of rats were treated daily for six months: control; fish liver oil

(0.4 ml/kg b.w); propolis (50 mg/kg b.w); pilocarpine-treated rats (epileptic

control); epileptic rats treated with valproate (400 mg/kg b.w); groups 6

and 7, epileptic rats treated with valproate plus fish liver oil or

propolis.

Results:

Pilocarpine administration caused a significant increase in hippocampal

dopamine and serotonin levels accompanied with a significant decrease in

their levels in serum. Lipid peroxidation level and LDH activity in hippocampus

were significantly increased after pilocarpine treatment whereas

Na+/K+-ATPase activity and total antioxidant capacity were significantly

decreased

compared to the controls. Animals treated with the combined treatments

showed a significant improvement in tested parameters towards the normal values

of the control. Conclusion: Fish liver oil and propolis when given in

combination with valproate, neuroprotected against the neurophysiological

disorders induced by pilocarpine epilepsy in rats.

Article Outline

1. Introduction

2. Materials and methods

2.1. Materials

2.2. Experimental animals

2.3. Induction of epilepsy

2.4. Experimental design

2.5. Sample preparation

2.6. Analytical determinations

2.7. Statistical analysis

3. Results

4. Discussion

5. Conclusion

References