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Curis Achieves Milestone under Wyeth Collaboration

CAMBRIDGE, MA , March 23, 2005 – Curis, Inc. (NASDAQ: CRIS), a

therapeutic drug development company, today announced that it has

achieved a development milestone under a collaboration with one of

its corporate partners, Wyeth Pharmaceuticals, a division of Wyeth

(NYSE: WYE). The milestone is based on Wyeth's and Curis' continued

progress in preclinical development of Hedgehog pathway agonists for

the treatment of stroke, neurological and other disorders. The

milestone will trigger a modest payment from Wyeth to Curis in

accordance with the terms of their 2004 agreement.

The Hedgehog signaling pathway regulates the normal development of

the brain and spinal cord. Wyeth and Curis are collaborating to

develop several promising small molecule agonist compounds that can

activate the Hedgehog signaling pathway and thereby promote nervous

system repair. Many of these small molecules are orally available and

can enter into the brain and spinal cord, thus making them an

attractive new class of drug development candidates for neurological

disorders.

Passeri, President and Chief Executive Officer of Curis,

said, " We are very pleased with the progress that has been made with

Wyeth in the Hedgehog agonist program. The achievement of this

milestone is an important next step in the path of bringing these

promising drug candidates towards clinical trials and ultimately to

the patients who need them. "

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