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Headaches-Germ Link Suggested

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Headaches-Germ Link Suggested

Fri Apr 26, 2:42 PM ET

By EMMA ROSS, AP Medical Writer

MILAN, Italy (AP) - Some headaches may be linked to infection with a

common bug and daily doses of friendly bacteria could ward them off,

preliminary research suggests.

A study presented Friday at an infectious diseases conference found that

about 18 percent of chronic migraine sufferers were infected with the

stomach bug helicobacter pylori and antibiotics appeared to clear the

headaches.

Adding the friendly bacteria Lactobacillus seemed to work even better,

leaving most people migraine-free for a year and lessening the intensity

and frequency of recurring headaches in the others, the lead researcher

said.

Experts were cautiously receptive to the idea but said the findings were

too tentative to draw any firm conclusions.

Helicobacter pylori, the bug that causes gut ulcers, has recently been

linked to a growing list of diseases, including heart disease, autoimmune

diseases and skin conditions.

In the study, Italian scientists divided 130 patients who had migraines

and were infected with helicobacter pylori into two groups.

One group was given a three-week course of antibiotics and the other got

the three weeks of antibiotics plus Lactobacillus, a friendly bacteria,

or probiotic, found in yogurt and other dairy products. The probiotic

group took three Lactobacillus doses a day for three months, then dropped

their intake to one dose a day for the next nine months.

One month after starting treatment, both groups were similar in terms of

headache symptoms and bacteria colonization.

However, after one year, significant differences were found, said the

study's leader, Dr. Gismondo, head of the clinical microbiology

laboratory at the University of Milan.

" We found that eradication of headache and bacteria was more significant

in the group treated with antibiotics and Lactobacillus, and relapse in

the people who took Lactobacillus was very low, but not in the people not

getting Lactobacillus therapy, " she said.

At the end of the year, 50 percent of the people who got the antibiotics

alone were still getting migraines. That compared with 20 percent in the

group who took the probiotics for a year.

Headaches in the probiotic group occurred less often, were milder and

went away more quickly than they did in the antibiotics group.

The infection findings were similar. After a year, the bacteria were 40

percent fewer in the group who took antibiotics and 70 percent fewer in

the group getting the combination treatment.

" Our understanding is that Lactobacillus could be used, not to cure or

eradicate H.pylori, because it is not an antibiotic, but to prevent

relapse of H.pylori infection, and headache. "

However, headache expert Dr. Goadsby, professor of clinical

neurology at the Institute of Neurology and the National Hospital for

Neurology and Neurosurgery in London, reserved judgment.

He said the fact that the study did not involve a group getting dummy

pills makes the findings less reliable. The study cannot rule out the

" placebo effect, " whereby people get better purely because they believe

the pills they are taking are working, not because the pills are actually

doing anything.

Goadsby said the placebo effect can account for up to 30 percent of the

improvement noted in studies like this one. Testing the effectiveness of

treatment by giving some people the medicine and some fake pills

overcomes that problem.

" There may be something in this ... but show me the money. I'd like to

see a placebo-controlled trial, " Goadsby said.

" If there was a chemical toxin that H.pylori produced that switched on

headaches, that wouldn't surprise me, " he said. " It's an interesting idea

and I think it's at a point where it should be dealt with in a rigorous

way because if it's true, it would be very useful and if it's not, we can

stop talking about it. "

http://story.news./news?tmpl=story & ncid=534 & e=1 & cid=534

& u=/ap/20020426/ap_on_he_me/headache_germ_1

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