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Nutrition of Cartilage

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Nutrition of Cartilage

Normal adult cartilage contains no blood vessels. Vascularization of

cartilage could alter its mechanical properties. Furthermore, blood flow

would be congested during weight bearing and exercise, with oxygen being

replaced during perfusion, which would result in repeated damage to

cartilage. To maintain cartilage as a structure that does not have blood

supply, certain cells must make specific chemicals to keep this space

healthy.

Much evidence indicates that synovial, which lines the joints, is the major

source of nutrients for cartilage. The fluid outside the joint of cartilage

is continuous with synovial fluid, which allows solutes to pass easily from

the synovial fluid into cartilage. Cartilage cannot survive without contact

with synovial fluid. In experimental systems, simple agitation of synovial

fluid results in nourishment of even the deepest layers of joint cartilage.

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