CR and insulin-like growth factor

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Hi All,

Reduction of plasma IGF-1 and CR may produce a similar

milieu that promotes survival in mammals.

Shimokawa I, Higami Y, Tsuchiya T, Otani H, Komatsu T,

Chiba T, Yamaza H.

Life span extension by reduction of the growth

hormone-insulin-like growth factor-1 axis: relation to

caloric restriction.

FASEB J. 2003 Jun;17(9):1108-9. Epub 2003 Apr 8.

PMID: 12692087 http://tinyurl.com/3y5uq7

Note, that the pathologies of those CR rats who died was

different from those of the ad libitum feeding rats.

Rats doing CR but with normal IGF-1

died more from cancers than other diseases. Pituitary

adenomas were less frequently seen in the

transgenic (ie reduced IGF-1) rats.

-- Al Pater, PhD; email: Alpater@...