Re: Fw: [CR] Methionine restriction like CR?

[Guest guest]

Hi folks:

It seems to me that in CR circles there is a widespread belief that,

within our restricted caloric budgets, we should maximize our intakes

of all essential nutrients.

The methionine issue makes me wonder how many other 'essential

nutrients' there are that also should be restricted to no more than

the amount we absolutely need.

Is it likely methionine is the only one?

Rodney.

>

>

> [CR] Methionine restriction like CR?

>

>

> > Is methionine restriction similar in its effects to those of CR?

The

> > below

> > paper is not pdf-availed.

> >

> >

> > Naudi A, Caro P, Jove M, Gomez J, Boada J, Ayala V, Portero-Otin

M,

> > Barja G,

> > Pamplona R.

> > Methionine Restriction Decreases Endogenous Oxidative Molecular

Damage

> > and

> > Increases Mitochondrial Biogenesis and Uncoupling Protein 4 in

Rat

> > Brain.

> > Rejuvenation Res. 2007 Jul 30; [Epub ahead of print]

> > PMID: 17716000

> >

> > Aging plays a central role in the occurrence of neurodegenerative

> > diseases.

> > Caloric restriction (CR) mitigates oxidative stress by decreasing

the

> > rate

> > of generation of endogenous damage, a mechanism that can

contribute to

> > the

> > slowing of the aging rate induced by this intervention. Various

> > reports have

> > recently linked methionine to aging, and methionine restriction

(MetR)

> > without energy restriction also increases life span.

> >

> > We have thus hypothesized that MetR can be responsible, at least

in

> > part,

> > for the decrease in endogenous oxidative damage in CR.

> >

> > In this investigation we subjected male rats to exactly the same

> > dietary

> > protocol of MetR that is known to increase their life span.

> >

> > We have found that MetR:

> >

> > (1) decreases the mitochondrial complex I content and activity,

as

> > well as

> > complex III content, while the complex II and IV, the

mitochondrial

> > flavoprotein apoptosis-inducing factor (AIF) and ATP content are

> > unchanged;

> >

> > (2) increases the mitochondrial biogenesis factor PGC-1alpha;

> >

> > (3) increases the resistance of brain to metabolic and oxidative

> > stress by

> > increasing mitochondrial uncoupling protein 4 uncoupling protein

4

> > (UCP4);

> > and

> >

> > (4) decreases mitochondrial oxidative DNA damage and all five

> > different

> > markers of protein oxidation measured and lowers membrane

unsaturation

> > in

> > rat brain. No changes were detected for protein amino acid

> > composition.

> >

> > These beneficial MetR-induced changes likely derived from

metabolic

> > reprogramming at the cellular and tissue level can play a key

role in

> > the

> > protection against aging-associated neurodegenerative disorders.

> >

> > -- Al Pater, alpater@...

> >

> >

> > _______________________________________________

> > CR@...

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> >

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> >

> >

>

[Guest guest]

Hi JR:

Just for clarification ........... I wasn't thinking so much about

the upper limits. But rather whether there are other nutrients (in

addition to what is beginning to look like the case for methionine)

for which the best health/lifespan outcome is associated with the

smallest possible intake consistent with no deficiency.

Of course this has not been proven for methionine yet. But evidence

seems to be accumulating.

Rodney.

>

> > Hi folks:

> >

> > It seems to me that in CR circles there is a widespread belief

that,

> > within our restricted caloric budgets, we should maximize our

intakes

> > of all essential nutrients.

> >

> > The methionine issue makes me wonder how many other 'essential

> > nutrients' there are that also should be restricted to no more

than

> > the amount we absolutely need.

> >

> > Is it likely methionine is the only one?

> >

> > Rodney.

> >

> > --- In , " Al Young " <acyoung@>

wrote:

> > >

> > >

> > > -

>

[Guest guest]

If you look at the amino acid profiles of proteins, you will find that

whey, soy, and yeast have approximately 30% less methionine than eggs,

fish, beef, and chicken.

By just switching your protein sources to whey, soy, and brewer's

yeast you would be restricting methionine by 30%. If in addition, you

practiced a Pritikin diet instead of a Zone diet, your overall protein

consumption would be at least 10% to 15% lower still. This would give

you a an overall reduction in methionine of about 40 to 45%.

Amino acid profiles of food proteins:

http://www.scientificpsychic.com/fitness/aminoacids1.html

Tony

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