Fw: [CR] Methionine restriction like CR?

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[CR] Methionine restriction like CR?

> Is methionine restriction similar in its effects to those of CR? The

> below

> paper is not pdf-availed.

>

>

> Naudi A, Caro P, Jove M, Gomez J, Boada J, Ayala V, Portero-Otin M,

> Barja G,

> Pamplona R.

> Methionine Restriction Decreases Endogenous Oxidative Molecular Damage

> and

> Increases Mitochondrial Biogenesis and Uncoupling Protein 4 in Rat

> Brain.

> Rejuvenation Res. 2007 Jul 30; [Epub ahead of print]

> PMID: 17716000

>

> Aging plays a central role in the occurrence of neurodegenerative

> diseases.

> Caloric restriction (CR) mitigates oxidative stress by decreasing the

> rate

> of generation of endogenous damage, a mechanism that can contribute to

> the

> slowing of the aging rate induced by this intervention. Various

> reports have

> recently linked methionine to aging, and methionine restriction (MetR)

> without energy restriction also increases life span.

>

> We have thus hypothesized that MetR can be responsible, at least in

> part,

> for the decrease in endogenous oxidative damage in CR.

>

> In this investigation we subjected male rats to exactly the same

> dietary

> protocol of MetR that is known to increase their life span.

>

> We have found that MetR:

>

> (1) decreases the mitochondrial complex I content and activity, as

> well as

> complex III content, while the complex II and IV, the mitochondrial

> flavoprotein apoptosis-inducing factor (AIF) and ATP content are

> unchanged;

>

> (2) increases the mitochondrial biogenesis factor PGC-1alpha;

>

> (3) increases the resistance of brain to metabolic and oxidative

> stress by

> increasing mitochondrial uncoupling protein 4 uncoupling protein 4

> (UCP4);

> and

>

> (4) decreases mitochondrial oxidative DNA damage and all five

> different

> markers of protein oxidation measured and lowers membrane unsaturation

> in

> rat brain. No changes were detected for protein amino acid

> composition.

>

> These beneficial MetR-induced changes likely derived from metabolic

> reprogramming at the cellular and tissue level can play a key role in

> the

> protection against aging-associated neurodegenerative disorders.

>

> -- Al Pater, alpater@...

>

>

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