Re: Study recommends higher intakes of Vit D

[Guest guest]

Hi folks:

JFI:

I have very recently been told by my GP (whose opinions on this kind

of stuff I greatly respect) that 80 nmol/L is now regarded as the low

extreme end of the acceptable range for 25(OH)D.

My reading was 71. In consequence I have been urged to take 50,000

IU of D per week (available only by prescription) for three months to

get my reading well above the low end of the range. Having satisfied

myself that this will not be toxic I am now doing it.

I will report in a few months what the results are ............. if

anyone expresses an interest.

(It looks like this may turn in to quite long story as I am also

currently doing regular calcaneal ultrasound bone mass tests and the

results, whatever they turn out to be in the end, already promise to

be quite illuminating!)

Rodney.

>

> Hi all:

>

> Vitamin D dosage study determines proper dosage to achieve optimum

> blood levels of 80 nanomoles per litre (nmol/L).

>

> They determined:

>

> Supplementation with 2000 IU is sufficient to raise levels to

greater

> than 50 nmol/L in most, but higher doses were needed to achieve

> concentrations greater than 75 nmol/L in some.

>

> 2800 IU is needed if you have blood levels of 45 nmol/L, and 4000 IU

> is needed if levels start at less than 45 nmol/L.

>

> Dave

>

>

> ++++++++++++++++++++++++

>

>

> Link:

>

> http://www.nutraingredients.com/news/ng.asp?

n=81998 & m=1NIED12 & c=lqeudkujayvvlpc

>

>

> full text:

>

> Vitamin D dose study adds weight to intake increases

>

> By ls

>

> 12/12/2007- Doses of vitamin D3 of 2,000 International Units (IU) -

> the current tolerable upper intake level (UL) in Europe and the US -

> are needed to ensure blood levels of the vitamin amongst

> post-menopausal African-American women, says a new study.

>

> Over 200 women took part in the three year study, published in the

> American Journal of Clinical Nutrition, which adds to an ever-

growing

> body of science suggesting an urgent need to review current daily

> intakes of the vitamin.

>

> Vitamin D is produced in the skin on exposure to UVB radiation and

can

> also be consumed in small amounts from the diet. However, increased

> skin pigmentation reduces the effect of UVB radiation meaning darker

> skinned people are more at risk of vitamin D deficiency.

>

> Vitamin D deficiency can lead to a range of health problems,

including

> rickets, poor tooth formation, convulsions, general ill health, and

> stunted growth. It has also been linked to an increased risk of

> certain cancers, cardiovascular disease, diabetes, and osteoporosis.

>

> Researchers from Winthrop University Hospital, Mineola, New York

> performed a dose-response experiment with 208 healthy African-

American

> postmenopausal women. Half the women were assigned to the vitamin D

> intervention arm of the trial and received daily supplements of 800

IU

> D3 (20 micrograms) for two years, and 2,000 IU (50 micrograms) for

the

> final year.

>

> Generally, blood levels of 25- hydroxyvitamin D (25(OH)D), the

> non-active 'storage' form, of 50 nanomoles per litre (nmol/L) are

> suggested as the lower limit of the normal range. Studies have

> reported however that levels of parathyroid hormone (PTH), a hormone

> that regulates calcium balance, and calcium absorption are not

> optimised below serum 25(OH)D levels of 80 nanomoles per litre.

>

> The authors, led by Talwar, report that the lower dose raised

> 25(OH)D levels from a baseline average of 47 nmol/L to 71.4 nmol/L

> after three months. After three months at the higher dose (2,000

IU),

> the average serum concentration of 25(OH)D was 87 nmol/L.

>

> Moreover, 95 per cent of the participants achieved a serum 25(OH)D

> concentration greater than 50 nmol/L, while levels greater than 75

> nmol/L were achieved by only 60 per cent.

>

> " Supplementation with 50 micrograms per day (2000 IU/d) oral vitamin

> D3 is sufficient to raise serum 25-hydroxyvitamin D concentrations

to

> greater than 50 nmol/L in almost all postmenopausal African American

> women, " wrote Talwar.

>

> " However, higher doses were needed to achieve concentrations greater

> than 75 nmol/L in many women in this population. "

>

> Taking their results one step further, they formulated an algorithm

in

> order to allow for the prescription of vitamin D needed to achieve

> optimal serum concentrations.

>

> Talwar and co-workers report that a daily dose of 2800 IU is needed

if

> the individual has a starting 25(OH)D level of at least 45 nmol/L,

> while a daily dose of 4000 IU is needed for individuals with 25(OH)D

> levels less than 45 nmol/L.

>

> Vitamin D refers to two biologically inactive precursors - D3, also

> known as cholecalciferol, and D2, also known as ergocalciferol. The

> former, produced in the skin on exposure to UVB radiation (290 to

320

> nm), is said to be more bioactive. The latter is derived from plants

> and only enters the body via the diet.

>

> Both D3 and D2 precursors are hydroxylated in the liver and kidneys

to

> form 25- hydroxyvitamin D (25(OH)D), the non-active 'storage' form,

> and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active

form

> that is tightly controlled by the body.

>

> A recent review of the science reported that the tolerable upper

> intake level for oral vitamin D3 should be increased five-fold, from

> the current tolerable upper intake level (UL) in Europe and the US

of

> 2000 International Units (IU), equivalent to 50 micrograms per day,

to

> 10,000 IU (250 micrograms per day) (American Journal of Clinical

> Nutrition, March 2007, Vol. 85, pp 649-650).

>

> Source: American Journal of Clinical Nutrition

> December 2007, Volume 86, Number 6, Pages 1657-1662

> " Dose response to vitamin D supplementation among postmenopausal

> African American women "

> Authors: S.A. Talwar, J.F. Aloia, S. Pollack and J.K. Yeh

>

[Guest guest]

At 11:19 AM 12/12/2007, you wrote:

>Hi folks:

>

>JFI:

>

>I have very recently been told by my GP (whose opinions on this kind

>of stuff I greatly respect) that 80 nmol/L is now regarded as the low

>extreme end of the acceptable range for 25(OH)D.

>

>My reading was 71. In consequence I have been urged to take 50,000

>IU of D per week (available only by prescription) for three months to

>get my reading well above the low end of the range. Having satisfied

>myself that this will not be toxic I am now doing it.

>

>I will report in a few months what the results are ............. if

>anyone expresses an interest.

Oh, certainly. I've been taking 3000 IU of over-the-counter D3 daily

for the past year, and when I next get tested, I'll share the results, too.

>Maco

[Guest guest]

I looked up my Vitamin D results and found that they were given in

terms of nanograms per ml. I found the molecular weight of Vitamin D3

here: http://www.cyberlipid.org/vitd/vitd0001.htm. He gives 384.6

gm/mole.

Using this information, 80 nmoles/L is approximately 31 ng/ml, which

you can compare with your results if they are expressed in ng/ml.

My D3 reading was 38 ng/ml.

Diane

> >

> > Hi all:

> >

> > Vitamin D dosage study determines proper dosage to achieve optimum

> > blood levels of 80 nanomoles per litre (nmol/L).

> >

> > They determined:

> >

> > Supplementation with 2000 IU is sufficient to raise levels to

> greater

> > than 50 nmol/L in most, but higher doses were needed to achieve

> > concentrations greater than 75 nmol/L in some.

> >

> > 2800 IU is needed if you have blood levels of 45 nmol/L, and 4000 IU

> > is needed if levels start at less than 45 nmol/L.

> >

> > Dave

> >

> >

> > ++++++++++++++++++++++++

> >

> >

> > Link:

> >

> > http://www.nutraingredients.com/news/ng.asp?

> n=81998 & m=1NIED12 & c=lqeudkujayvvlpc

> >

> >

> > full text:

> >

> > Vitamin D dose study adds weight to intake increases

> >

> > By ls

> >

> > 12/12/2007- Doses of vitamin D3 of 2,000 International Units (IU) -

> > the current tolerable upper intake level (UL) in Europe and the US -

> > are needed to ensure blood levels of the vitamin amongst

> > post-menopausal African-American women, says a new study.

> >

> > Over 200 women took part in the three year study, published in the

> > American Journal of Clinical Nutrition, which adds to an ever-

> growing

> > body of science suggesting an urgent need to review current daily

> > intakes of the vitamin.

> >

> > Vitamin D is produced in the skin on exposure to UVB radiation and

> can

> > also be consumed in small amounts from the diet. However, increased

> > skin pigmentation reduces the effect of UVB radiation meaning darker

> > skinned people are more at risk of vitamin D deficiency.

> >

> > Vitamin D deficiency can lead to a range of health problems,

> including

> > rickets, poor tooth formation, convulsions, general ill health, and

> > stunted growth. It has also been linked to an increased risk of

> > certain cancers, cardiovascular disease, diabetes, and osteoporosis.

> >

> > Researchers from Winthrop University Hospital, Mineola, New York

> > performed a dose-response experiment with 208 healthy African-

> American

> > postmenopausal women. Half the women were assigned to the vitamin D

> > intervention arm of the trial and received daily supplements of 800

> IU

> > D3 (20 micrograms) for two years, and 2,000 IU (50 micrograms) for

> the

> > final year.

> >

> > Generally, blood levels of 25- hydroxyvitamin D (25(OH)D), the

> > non-active 'storage' form, of 50 nanomoles per litre (nmol/L) are

> > suggested as the lower limit of the normal range. Studies have

> > reported however that levels of parathyroid hormone (PTH), a hormone

> > that regulates calcium balance, and calcium absorption are not

> > optimised below serum 25(OH)D levels of 80 nanomoles per litre.

> >

> > The authors, led by Talwar, report that the lower dose raised

> > 25(OH)D levels from a baseline average of 47 nmol/L to 71.4 nmol/L

> > after three months. After three months at the higher dose (2,000

> IU),

> > the average serum concentration of 25(OH)D was 87 nmol/L.

> >

> > Moreover, 95 per cent of the participants achieved a serum 25(OH)D

> > concentration greater than 50 nmol/L, while levels greater than 75

> > nmol/L were achieved by only 60 per cent.

> >

> > " Supplementation with 50 micrograms per day (2000 IU/d) oral vitamin

> > D3 is sufficient to raise serum 25-hydroxyvitamin D concentrations

> to

> > greater than 50 nmol/L in almost all postmenopausal African American

> > women, " wrote Talwar.

> >

> > " However, higher doses were needed to achieve concentrations greater

> > than 75 nmol/L in many women in this population. "

> >

> > Taking their results one step further, they formulated an algorithm

> in

> > order to allow for the prescription of vitamin D needed to achieve

> > optimal serum concentrations.

> >

> > Talwar and co-workers report that a daily dose of 2800 IU is needed

> if

> > the individual has a starting 25(OH)D level of at least 45 nmol/L,

> > while a daily dose of 4000 IU is needed for individuals with 25(OH)D

> > levels less than 45 nmol/L.

> >

> > Vitamin D refers to two biologically inactive precursors - D3, also

> > known as cholecalciferol, and D2, also known as ergocalciferol. The

> > former, produced in the skin on exposure to UVB radiation (290 to

> 320

> > nm), is said to be more bioactive. The latter is derived from plants

> > and only enters the body via the diet.

> >

> > Both D3 and D2 precursors are hydroxylated in the liver and kidneys

> to

> > form 25- hydroxyvitamin D (25(OH)D), the non-active 'storage' form,

> > and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active

> form

> > that is tightly controlled by the body.

> >

> > A recent review of the science reported that the tolerable upper

> > intake level for oral vitamin D3 should be increased five-fold, from

> > the current tolerable upper intake level (UL) in Europe and the US

> of

> > 2000 International Units (IU), equivalent to 50 micrograms per day,

> to

> > 10,000 IU (250 micrograms per day) (American Journal of Clinical

> > Nutrition, March 2007, Vol. 85, pp 649-650).

> >

> > Source: American Journal of Clinical Nutrition

> > December 2007, Volume 86, Number 6, Pages 1657-1662

> > " Dose response to vitamin D supplementation among postmenopausal

> > African American women "

> > Authors: S.A. Talwar, J.F. Aloia, S. Pollack and J.K. Yeh

> >

>

[Guest guest]

Hi folks:

Minor correction. For 25(OH)D: deficiency is defined as <25;

insufficiency is defined as 25 - 75; sufficiency is from 76 to 250;

toxicity is >250 - all in units of nmol/L.

There is a note that these new reference ranges came into effect on

10th September 2007.

ERodney.

> > >

> > > Hi all:

> > >

> > > Vitamin D dosage study determines proper dosage to achieve

optimum

> > > blood levels of 80 nanomoles per litre (nmol/L).

> > >

> > > They determined:

> > >

> > > Supplementation with 2000 IU is sufficient to raise levels to

> > greater

> > > than 50 nmol/L in most, but higher doses were needed to achieve

> > > concentrations greater than 75 nmol/L in some.

> > >

> > > 2800 IU is needed if you have blood levels of 45 nmol/L, and

4000 IU

> > > is needed if levels start at less than 45 nmol/L.

> > >

> > > Dave

> > >

> > >

> > > ++++++++++++++++++++++++

> > >

> > >

> > > Link:

> > >

> > > http://www.nutraingredients.com/news/ng.asp?

> > n=81998 & m=1NIED12 & c=lqeudkujayvvlpc

> > >

> > >

> > > full text:

> > >

> > > Vitamin D dose study adds weight to intake increases

> > >

> > > By ls

> > >

> > > 12/12/2007- Doses of vitamin D3 of 2,000 International Units

(IU) -

> > > the current tolerable upper intake level (UL) in Europe and the

US -

> > > are needed to ensure blood levels of the vitamin amongst

> > > post-menopausal African-American women, says a new study.

> > >

> > > Over 200 women took part in the three year study, published in

the

> > > American Journal of Clinical Nutrition, which adds to an ever-

> > growing

> > > body of science suggesting an urgent need to review current

daily

> > > intakes of the vitamin.

> > >

> > > Vitamin D is produced in the skin on exposure to UVB radiation

and

> > can

> > > also be consumed in small amounts from the diet. However,

increased

> > > skin pigmentation reduces the effect of UVB radiation meaning

darker

> > > skinned people are more at risk of vitamin D deficiency.

> > >

> > > Vitamin D deficiency can lead to a range of health problems,

> > including

> > > rickets, poor tooth formation, convulsions, general ill health,

and

> > > stunted growth. It has also been linked to an increased risk of

> > > certain cancers, cardiovascular disease, diabetes, and

osteoporosis.

> > >

> > > Researchers from Winthrop University Hospital, Mineola, New York

> > > performed a dose-response experiment with 208 healthy African-

> > American

> > > postmenopausal women. Half the women were assigned to the

vitamin D

> > > intervention arm of the trial and received daily supplements of

800

> > IU

> > > D3 (20 micrograms) for two years, and 2,000 IU (50 micrograms)

for

> > the

> > > final year.

> > >

> > > Generally, blood levels of 25- hydroxyvitamin D (25(OH)D), the

> > > non-active 'storage' form, of 50 nanomoles per litre (nmol/L)

are

> > > suggested as the lower limit of the normal range. Studies have

> > > reported however that levels of parathyroid hormone (PTH), a

hormone

> > > that regulates calcium balance, and calcium absorption are not

> > > optimised below serum 25(OH)D levels of 80 nanomoles per litre.

> > >

> > > The authors, led by Talwar, report that the lower dose

raised

> > > 25(OH)D levels from a baseline average of 47 nmol/L to 71.4

nmol/L

> > > after three months. After three months at the higher dose

(2,000

> > IU),

> > > the average serum concentration of 25(OH)D was 87 nmol/L.

> > >

> > > Moreover, 95 per cent of the participants achieved a serum 25

(OH)D

> > > concentration greater than 50 nmol/L, while levels greater than

75

> > > nmol/L were achieved by only 60 per cent.

> > >

> > > " Supplementation with 50 micrograms per day (2000 IU/d) oral

vitamin

> > > D3 is sufficient to raise serum 25-hydroxyvitamin D

concentrations

> > to

> > > greater than 50 nmol/L in almost all postmenopausal African

American

> > > women, " wrote Talwar.

> > >

> > > " However, higher doses were needed to achieve concentrations

greater

> > > than 75 nmol/L in many women in this population. "

> > >

> > > Taking their results one step further, they formulated an

algorithm

> > in

> > > order to allow for the prescription of vitamin D needed to

achieve

> > > optimal serum concentrations.

> > >

> > > Talwar and co-workers report that a daily dose of 2800 IU is

needed

> > if

> > > the individual has a starting 25(OH)D level of at least 45

nmol/L,

> > > while a daily dose of 4000 IU is needed for individuals with 25

(OH)D

> > > levels less than 45 nmol/L.

> > >

> > > Vitamin D refers to two biologically inactive precursors - D3,

also

> > > known as cholecalciferol, and D2, also known as ergocalciferol.

The

> > > former, produced in the skin on exposure to UVB radiation (290

to

> > 320

> > > nm), is said to be more bioactive. The latter is derived from

plants

> > > and only enters the body via the diet.

> > >

> > > Both D3 and D2 precursors are hydroxylated in the liver and

kidneys

> > to

> > > form 25- hydroxyvitamin D (25(OH)D), the non-active 'storage'

form,

> > > and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically

active

> > form

> > > that is tightly controlled by the body.

> > >

> > > A recent review of the science reported that the tolerable upper

> > > intake level for oral vitamin D3 should be increased five-fold,

from

> > > the current tolerable upper intake level (UL) in Europe and the

US

> > of

> > > 2000 International Units (IU), equivalent to 50 micrograms per

day,

> > to

> > > 10,000 IU (250 micrograms per day) (American Journal of Clinical

> > > Nutrition, March 2007, Vol. 85, pp 649-650).

> > >

> > > Source: American Journal of Clinical Nutrition

> > > December 2007, Volume 86, Number 6, Pages 1657-1662

> > > " Dose response to vitamin D supplementation among postmenopausal

> > > African American women "

> > > Authors: S.A. Talwar, J.F. Aloia, S. Pollack and J.K. Yeh

> > >

> >

>

[Guest guest]

For Al Pater doctor visits; lab tests25-OH vitamin D (Jul/00, 52 vs 25-200) Aug/24/07 172 40-250 nM; <25, deficient; 25-39, sufficient; >250, toxic AlRodney <perspect1111@...> wrote: Hi folks:Minor correction. For 25(OH)D: deficiency is defined as <25; insufficiency is defined as 25 - 75; sufficiency is from 76 to 250; toxicity is >250 - all in units of nmol/L.There is a note that these new reference ranges came into effect on 10th September 2007.ERodney.> > >> > > Hi all:> > > > > > Vitamin D dosage study determines proper dosage to achieve optimum> > > blood levels of 80 nanomoles per litre (nmol/L). > > > > > > They determined:> > > > > > Supplementation with 2000 IU is sufficient to raise levels to > > greater> > > than 50 nmol/L in most, but higher doses were needed to achieve> > > concentrations greater than 75 nmol/L in some.> > > > > > 2800 IU is needed if you have blood levels of 45 nmol/L, and 4000 IU> > > is needed if levels start at less than 45

nmol/L.> > > > > > Dave> > > > > > > > > ++++++++++++++++++++++++> > > > > > > > > Link:> > > > > > http://www.nutraingredients.com/news/ng.asp?> > n=81998 & m=1NIED12 & c=lqeudkujayvvlpc> > > > > > > > > full text:> > > > > > Vitamin D dose study adds weight to intake increases> > > > > > By ls> > > > > > 12/12/2007- Doses of vitamin D3 of 2,000 International Units (IU) -> > > the current tolerable upper intake level (UL) in Europe and the US -> > > are needed to ensure blood levels of the vitamin amongst> > > post-menopausal African-American women, says a new

study.> > > > > > Over 200 women took part in the three year study, published in the> > > American Journal of Clinical Nutrition, which adds to an ever-> > growing> > > body of science suggesting an urgent need to review current daily> > > intakes of the vitamin.> > > > > > Vitamin D is produced in the skin on exposure to UVB radiation and > > can> > > also be consumed in small amounts from the diet. However, increased> > > skin pigmentation reduces the effect of UVB radiation meaning darker> > > skinned people are more at risk of vitamin D deficiency.> > > > > > Vitamin D deficiency can lead to a range of health problems, > > including> > > rickets, poor tooth formation, convulsions, general ill health, and> > > stunted growth. It has also

been linked to an increased risk of> > > certain cancers, cardiovascular disease, diabetes, and osteoporosis.> > > > > > Researchers from Winthrop University Hospital, Mineola, New York> > > performed a dose-response experiment with 208 healthy African-> > American> > > postmenopausal women. Half the women were assigned to the vitamin D> > > intervention arm of the trial and received daily supplements of 800 > > IU> > > D3 (20 micrograms) for two years, and 2,000 IU (50 micrograms) for > > the> > > final year.> > > > > > Generally, blood levels of 25- hydroxyvitamin D (25(OH)D), the> > > non-active 'storage' form, of 50 nanomoles per litre (nmol/L) are> > > suggested as the lower limit of the normal range. Studies have> > > reported however that levels of

parathyroid hormone (PTH), a hormone> > > that regulates calcium balance, and calcium absorption are not> > > optimised below serum 25(OH)D levels of 80 nanomoles per litre.> > > > > > The authors, led by Talwar, report that the lower dose raised> > > 25(OH)D levels from a baseline average of 47 nmol/L to 71.4 nmol/L> > > after three months. After three months at the higher dose (2,000 > > IU),> > > the average serum concentration of 25(OH)D was 87 nmol/L.> > > > > > Moreover, 95 per cent of the participants achieved a serum 25(OH)D> > > concentration greater than 50 nmol/L, while levels greater than 75> > > nmol/L were achieved by only 60 per cent.> > > > > > "Supplementation with 50 micrograms per day (2000 IU/d) oral vitamin> > > D3 is sufficient

to raise serum 25-hydroxyvitamin D concentrations > > to> > > greater than 50 nmol/L in almost all postmenopausal African American> > > women," wrote Talwar.> > > > > > "However, higher doses were needed to achieve concentrations greater> > > than 75 nmol/L in many women in this population."> > > > > > Taking their results one step further, they formulated an algorithm > > in> > > order to allow for the prescription of vitamin D needed to achieve> > > optimal serum concentrations.> > > > > > Talwar and co-workers report that a daily dose of 2800 IU is needed > > if> > > the individual has a starting 25(OH)D level of at least 45 nmol/L,> > > while a daily dose of 4000 IU is needed for individuals with 25(OH)D> > > levels less than 45

nmol/L.> > > > > > Vitamin D refers to two biologically inactive precursors - D3, also> > > known as cholecalciferol, and D2, also known as ergocalciferol. The> > > former, produced in the skin on exposure to UVB radiation (290 to > > 320> > > nm), is said to be more bioactive. The latter is derived from plants> > > and only enters the body via the diet.> > > > > > Both D3 and D2 precursors are hydroxylated in the liver and kidneys > > to> > > form 25- hydroxyvitamin D (25(OH)D), the non-active 'storage' form,> > > and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active > > form> > > that is tightly controlled by the body.> > > > > > A recent review of the science reported that the tolerable upper> > > intake level

for oral vitamin D3 should be increased five-fold, from> > > the current tolerable upper intake level (UL) in Europe and the US > > of> > > 2000 International Units (IU), equivalent to 50 micrograms per day, > > to> > > 10,000 IU (250 micrograms per day) (American Journal of Clinical> > > Nutrition, March 2007, Vol. 85, pp 649-650).> > > > > > Source: American Journal of Clinical Nutrition> > > December 2007, Volume 86, Number 6, Pages 1657-1662> > > "Dose response to vitamin D supplementation among postmenopausal> > > African American women"> > > Authors: S.A. Talwar, J.F. Aloia, S. Pollack and J.K. Yeh> > >> >>

Be a better friend, newshound, and know-it-all with Mobile. Try it now.

[Guest guest]

Hi folks:

Regarding medical conversion factors generally: The following link

seems to be quite a useful source:

http://www.members.optusnet.com.au/ncrick/converters/molecular_mass.h

tml

Diane will be pleased to hear that for vitamin D it confirms her

calculations!

Rodney.

>

> I looked up my Vitamin D results and found that they were given in

> terms of nanograms per ml. I found the molecular weight of

Vitamin D3

> here: http://www.cyberlipid.org/vitd/vitd0001.htm. He gives 384.6

> gm/mole.

>

> Using this information, 80 nmoles/L is approximately 31 ng/ml,

which

> you can compare with your results if they are expressed in ng/ml.

>

> My D3 reading was 38 ng/ml.

>

> Diane

>

>

>

>

>

>

> --- In , " Rodney " <perspect1111@>

wrote:

> >

> > Hi folks:

> >

> > JFI:

> >

> > I have very recently been told by my GP (whose opinions on this

kind

> > of stuff I greatly respect) that 80 nmol/L is now regarded as

the low

> > extreme end of the acceptable range for 25(OH)D.

> >

> > My reading was 71. In consequence I have been urged to take

50,000

> > IU of D per week (available only by prescription) for three

months to

> > get my reading well above the low end of the range. Having

satisfied

> > myself that this will not be toxic I am now doing it.

> >

> > I will report in a few months what the results

are ............. if

> > anyone expresses an interest.

> >

> > (It looks like this may turn in to quite long story as I am also

> > currently doing regular calcaneal ultrasound bone mass tests and

the

> > results, whatever they turn out to be in the end, already

promise to

> > be quite illuminating!)

> >

> > Rodney.

> >

> > --- In , " Dave " <davemaddux@>

wrote:

> > >

> > > Hi all:

> > >

> > > Vitamin D dosage study determines proper dosage to achieve

optimum

> > > blood levels of 80 nanomoles per litre (nmol/L).

> > >

> > > They determined:

> > >

> > > Supplementation with 2000 IU is sufficient to raise levels to

> > greater

> > > than 50 nmol/L in most, but higher doses were needed to achieve

> > > concentrations greater than 75 nmol/L in some.

> > >

> > > 2800 IU is needed if you have blood levels of 45 nmol/L, and

4000 IU

> > > is needed if levels start at less than 45 nmol/L.

> > >

> > > Dave

> > >

> > >

> > > ++++++++++++++++++++++++

> > >

> > >

> > > Link:

> > >

> > > http://www.nutraingredients.com/news/ng.asp?

> > n=81998 & m=1NIED12 & c=lqeudkujayvvlpc

> > >

> > >

> > > full text:

> > >

> > > Vitamin D dose study adds weight to intake increases

> > >

> > > By ls

> > >

> > > 12/12/2007- Doses of vitamin D3 of 2,000 International Units

(IU) -

> > > the current tolerable upper intake level (UL) in Europe and

the US -

> > > are needed to ensure blood levels of the vitamin amongst

> > > post-menopausal African-American women, says a new study.

> > >

> > > Over 200 women took part in the three year study, published in

the

> > > American Journal of Clinical Nutrition, which adds to an ever-

> > growing

> > > body of science suggesting an urgent need to review current

daily

> > > intakes of the vitamin.

> > >

> > > Vitamin D is produced in the skin on exposure to UVB radiation

and

> > can

> > > also be consumed in small amounts from the diet. However,

increased

> > > skin pigmentation reduces the effect of UVB radiation meaning

darker

> > > skinned people are more at risk of vitamin D deficiency.

> > >

> > > Vitamin D deficiency can lead to a range of health problems,

> > including

> > > rickets, poor tooth formation, convulsions, general ill

health, and

> > > stunted growth. It has also been linked to an increased risk of

> > > certain cancers, cardiovascular disease, diabetes, and

osteoporosis.

> > >

> > > Researchers from Winthrop University Hospital, Mineola, New

York

> > > performed a dose-response experiment with 208 healthy African-

> > American

> > > postmenopausal women. Half the women were assigned to the

vitamin D

> > > intervention arm of the trial and received daily supplements

of 800

> > IU

> > > D3 (20 micrograms) for two years, and 2,000 IU (50 micrograms)

for

> > the

> > > final year.

> > >

> > > Generally, blood levels of 25- hydroxyvitamin D (25(OH)D), the

> > > non-active 'storage' form, of 50 nanomoles per litre (nmol/L)

are

> > > suggested as the lower limit of the normal range. Studies have

> > > reported however that levels of parathyroid hormone (PTH), a

hormone

> > > that regulates calcium balance, and calcium absorption are not

> > > optimised below serum 25(OH)D levels of 80 nanomoles per litre.

> > >

> > > The authors, led by Talwar, report that the lower dose

raised

> > > 25(OH)D levels from a baseline average of 47 nmol/L to 71.4

nmol/L

> > > after three months. After three months at the higher dose

(2,000

> > IU),

> > > the average serum concentration of 25(OH)D was 87 nmol/L.

> > >

> > > Moreover, 95 per cent of the participants achieved a serum 25

(OH)D

> > > concentration greater than 50 nmol/L, while levels greater

than 75

> > > nmol/L were achieved by only 60 per cent.

> > >

> > > " Supplementation with 50 micrograms per day (2000 IU/d) oral

vitamin

> > > D3 is sufficient to raise serum 25-hydroxyvitamin D

concentrations

> > to

> > > greater than 50 nmol/L in almost all postmenopausal African

American

> > > women, " wrote Talwar.

> > >

> > > " However, higher doses were needed to achieve concentrations

greater

> > > than 75 nmol/L in many women in this population. "

> > >

> > > Taking their results one step further, they formulated an

algorithm

> > in

> > > order to allow for the prescription of vitamin D needed to

achieve

> > > optimal serum concentrations.

> > >

> > > Talwar and co-workers report that a daily dose of 2800 IU is

needed

> > if

> > > the individual has a starting 25(OH)D level of at least 45

nmol/L,

> > > while a daily dose of 4000 IU is needed for individuals with 25

(OH)D

> > > levels less than 45 nmol/L.

> > >

> > > Vitamin D refers to two biologically inactive precursors - D3,

also

> > > known as cholecalciferol, and D2, also known as

ergocalciferol. The

> > > former, produced in the skin on exposure to UVB radiation (290

to

> > 320

> > > nm), is said to be more bioactive. The latter is derived from

plants

> > > and only enters the body via the diet.

> > >

> > > Both D3 and D2 precursors are hydroxylated in the liver and

kidneys

> > to

> > > form 25- hydroxyvitamin D (25(OH)D), the non-active 'storage'

form,

> > > and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically

active

> > form

> > > that is tightly controlled by the body.

> > >

> > > A recent review of the science reported that the tolerable

upper

> > > intake level for oral vitamin D3 should be increased five-

fold, from

> > > the current tolerable upper intake level (UL) in Europe and

the US

> > of

> > > 2000 International Units (IU), equivalent to 50 micrograms per

day,

> > to

> > > 10,000 IU (250 micrograms per day) (American Journal of

Clinical

> > > Nutrition, March 2007, Vol. 85, pp 649-650).

> > >

> > > Source: American Journal of Clinical Nutrition

> > > December 2007, Volume 86, Number 6, Pages 1657-1662

> > > " Dose response to vitamin D supplementation among

postmenopausal

> > > African American women "

> > > Authors: S.A. Talwar, J.F. Aloia, S. Pollack and J.K. Yeh

> > >

> >

>