D-Mannose to prevent UTIs?

[Guest guest]

,

As Francesca mentioned, sites that sell products sometimes embellish

the claims and their references are often alternative health magazines

rather than refereed scientific journals. PubMed allows you to

search reputable scientific journals:

http://www.ncbi.nlm.nih.gov/sites/entrez

You can also use Google or by searching only .gov sites, e.g.,

" mannose urinary infection site:.gov "

It turns out that D-Mannose has been found to inhibit adherence of E.

coli to urinary tract cells. For example:

>>>

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=551344

Infect Immun. 1980 November; 30(2): 531–537.

Effect of carbohydrates on adherence of Escherichica coli to human

urinary tract epithelial cells.

A J Schaeffer, S K Amundsen, and J M

Abstract

Adherence of Escherichia coli cells to voided uroepithelial cells from

healthy women was measured by use of [3H]uridine-labeled bacteria

filtered through a polycarbonate membrane filter (5-micrometer pore

size). At a concentration of 2.5% (wt/vol), D-mannose, D-mannitol,

alpha-methyl-D-mannoside, and yeast mannan completely inhibited

adherence of the bacteria to the epithelial cells. At this same

concentration, D-fructose, D-lyxose, D-arabinose, and D-glyceraldehyde

partially inhibited adherence. Reducing the concentration of

D-mannose, or its derivatives, to between 1.0 and 0.1% resulted in

partial inhibition in the adherence of the bacteria; a further

reduction in the concentration to between 0.01 and 0.001% caused an

enhancement of adherence up to 160% of the control level. Bacterial

preincubation in 2.5% D-mannose for 1 min before epithelial cells were

added completely inhibited adherence; similar treatment of the

epithelial cells had no significant effect on subsequent adherence of

the bacteria. Bacteria that were preincubated for 1 h with D-mannose

at concentrations between 0.1 and 0.75% showed enhanced adherence. The

inhibitory effect of D-mannose was decreased if bacterial adhesive

ability, or cell receptivity, increased. A variety of other

carbohydrates tested had no effect on the adherence of E. coli to the

uroepithelial cells. These results suggest that adherence can be

altered by interaction(s) between specific carbohydrate molecules and

receptors on the bacterial surface.

>>>

The question of whether oral administration of D-Mannose could achieve

the concentrations required for inhibition in vivo is not discussed in

this paper.

Tony

> > >

> > > Has she tried eating yogurt? Has she tried garlic?

> > >

> > >

> > >

> > > From: nmbuczyn <nmbuczyn@>

> > > Reply-<

> > <mailto: %40> >

> > > Date: Tue, 18 Dec 2007 12:11:40 -0000

> > > <

> <mailto: %40>

> > >

> > > Subject: [ ] Off topic - pH to prevent UTIs?

> > >

> > >

> > >

> > >

> > >

> > > Hi, all - I have a question. My friend, who consistently gets 1-2

> > > urinary tract infections each year, is searching for a preventitive

> > > measure other than the stadards suggested by the MDs (which she

> already

> > > does-cranberry juice, don't hold a full bladder, etc.). I was

> wondering

> > > if altering her body's pH and making it more acidic (through diet or

> > > large intake of vitamin C) once per week could kill off any

growth of

> > > the offending bacteria in her urinary tract. Any ideas? Thanks, N

> > >

> >

>

[Guest guest]

Another study but in Rats (below).

However I've spoken to many people on different forums that have suffered repeated urine infections, mostly women, and they were advised by their doctor to go on cipro, bactrim at low doses indefintely... they looked for other solutions and one that seems to help benefit them, from what I've read is D mannose.

Effect of D-mannose and D-glucose on Escherichia coli bacteriuria in rats.s EK, Chmiel JS, Plotkin BJ, Schaeffer AJ.

The effect of D-mannose and D-glucose on bacteriuria due to Escherichia coli with mannose-sensitive adhesins was investigated in adult male Sprague-Dawley rats undergoing diuresis. Inocula of 10(5), 10(7), or 10(8) bacteria in 0.1 ml of normal saline or 2.5% or 10% D-mannose or D-glucose were injected intravesically and urine was cultured 1, 3, 5, 7 and 9 days later. The levels of bacteriuria on days 1 and 5 were significantly lower in rats inoculated with 10(5) E coli and 10% D-mannose than in controls (p less than 0.05 and 0.01 respectively) and the percentages of rats with less than 100 bacteria/ml were higher on days 1 and 3 (p = 0.05 and 0.02 respectively). Bacteriuria was significantly lower in rats inoculated with 10(7) bacteria and 10% D-mannose than in controls on days 5 and 7 (p less than 0.01 for each day) and the percentage of rats with less than 100 bacteria/ml was higher on day 7 (p = 0.01). D-glucose reduced bacteriuria significantly only with a concentration of 10% after instillation of 10(5) E. coli (p less than 0.05, day 1). The results indicate that D-mannose and D-glucose can significantly reduce bacteriuria within 1 day and that their efficacy is dependent upon the concentration of both saccharide and bacteria.

PMID: 6346629 [PubMed - indexed for MEDLINE]

[ ] Off topic - pH to prevent UTIs?> > >> > >> > >> > >> > >> > > Hi, all - I have a question. My friend, who consistently gets 1-2> > > urinary tract infections each year, is searching for a preventitive> > > measure other than the stadards suggested by the MDs (which she> already> > > does-cranberry juice, don't hold a full bladder, etc.). I was> wondering> > > if altering her body's pH and making it more acidic (through diet or> > > large intake of vitamin C) once per week could kill off anygrowth of> > > the offending bacteria in her urinary tract. Any ideas? Thanks, N> > >> >>

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