Re: Hi Carb vs Hi Fat On Endothelial Function

[Guest guest]

Hi folks:

And this is further confirmation of Dr. Castelli's point discussed

here a couple of years ago. That fasting cholesterol numbers

substantially understate the dangers of a high fat meal because the

the dangerous particles that are absorbed into the bloodstream

immediately after the food is eaten ('chylomicrons' I believe)

diminish dramatically during an overnight fast, giving only a hint of

how high they had been earlier.

Rodney.

--- In , Jeff Novick <chefjeff40@...>

wrote:

>

> American Journal of Clinical Nutrition, Vol. 86, No.

> 4, 923-928, October 2007

>

> Effects of dietary composition on postprandial

> endothelial function and adiponectin concentrations in

> healthy humans: a crossover controlled study1,2

> Michio Shimabukuro, Ichiro Chinen, Namio Higa,

> Nobuyuki Takasu, Ken Yamakawa and Shinichiro Ueda

>

> 1 From the Second Department of Internal Medicine (MS,

> IC, NH, and NT), the Department of Clinical

> Pharmacology and Therapeutics (KY and SU), and the

> Faculty of Medicine, University of the Ryukyus,

> Okinawa, Japan

>

> Background: Abnormalities during the postprandial

> state contribute to the development of

> atherosclerosis. Reportedly, postprandial

> hyperglycemia, hypertriglyceridemia, and

> hyperlipacidemia independently cause postprandial

> cytokine activation. However, it is not clear which

> dietary composition preferentially affects

> postprandial endothelial function in healthy subjects.

>

> Objective: We aimed to examine the associations of

> dietary composition and postprandial endothelial

> function in healthy subjects.

>

> Design: The effects of a single ingestion of a

> high-carbohydrate meal (300 kcal, 100% carbohydrate),

> a high-fat meal (30 g fat/m2, 35% fat), or a standard

> test meal (478 kcal; 16.4% protein, 32.7% fat, 50.4%

> carbohydrate) on postprandial plasma concentrations of

> adiponectin and forearm blood flow (FBF) during

> reactive hyperemia were studied in healthy subjects.

>

> Results: The peak FBF response and the total reactive

> hyperemic flow (flow debt repayment; FDR), indexes of

> resistance artery endothelial function, were unchanged

> after ingestion of a high-carbohydrate and standard

> test meal but decreased 120 and 240 min after a

> high-fat meal. After a high-fat meal, decreases in

> peak FBF and FDR were well correlated with an increase

> in plasma free fatty acid (FFA) concentrations but not

> with the other biochemical variables, including

> triacylglycerol, insulin, glucose, total cholesterol,

> HDL cholesterol, and adiponectin.

>

> Conclusions: Postprandial endothelial function was

> impaired only after the high-fat diet and not after

> the high-carbohydrate or standard test meal in healthy

> subjects. Because such endothelial dysfunction after a

> high-fat meal was closely correlated with FFA

> concentrations, postprandial state could be hazardous,

> mostly through acute hyperlipacidemia in healthy subjects.

>