Hi Carb vs Hi Fat CR Diet

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The below paper is pdf-availed and appears to favor CRed low-carbohydrate (LC) diets. The high carbohydrate (HC) diet had much more beta-cornstarch, much less cellulose powder and much less oleic acid and uniquely some palmitic and renoic acid. Body weight decreases were for the different groups: HC, 30 g; LC, 36 g; http://en.wikipedia.org/wiki/Pioglitazone - treated HC (P-HC), 22 g. Fasting blood glucose was decreased just a little more in the P-HC rats. Insulin level in pg/ml decreases were: HC, -900; LC, -1200, p <0.05; P-HC, -1350, p <0.05. Cholesterol decreased in mg/dL, respectively: -40; -80, p <0.05; -90, p <0.05. TG decreased in mg/dL, respectively: 170; 235, p <0.05; 260, p <0.05.. HDL changed in mg/dL, respectively: -2; + 1.5; +2.Koide N, Oyama T, Miyashita Y, Shirai K.Effects of Calorie-Restricted Low-Carbohydrate Diet on Glucose

and Lipid Metabolism in Otsuka Long Tokushima Fatty Rats.J Atheroscler Thromb. 2007 Oct 12; [Epub ahead of print]PMID: 17938540Aim: We investigated the effects of a calorie-restricted low-carbohydrate diet on glucose and lipid metabolism, and body fat distribution, especially on the secretion of leptin and lipoprotein lipase from adipose tissue in Otsuka Long Tokushima Fatty (OLETF) rats.Methods: Forty-three week-old male OLETF rats were randomized into three groups (n=6 per group): the HC group (HC) was fed a diet with 60% carbohydrate; the LC group (LC) with 30% carbohydrate; and the P-HC group (P-HC) with 60% carbohydrate and pioglitazone (0.1%). The total calorie intake was restricted to 70% of the average intake from each diet (60 kcal/day). The diets were continued for 8 weeks.Results: Similar decreases in body weight and serum glucose were observed in the three groups. Serum insulin concentration was significantly

decreased in LC and P-HC compared to HC. Serum total cholesterol and triglycerides decreased significantly (p<0.05) in LC and P-HC compared to HC. The decrease of visceral fat area measured by computed tomography was greatest in LC among the three groups. At the end of the diet, leptin secretion from visceral adipose tissue and lipoprotein lipase (LPL) activity in subcutaneous adipose tissue were significantly higher in LC and P-HC compared to HC (p<0.05).Conclusion: These results indicate that under calorie-restricted conditions, low carbohydrates are much more effective than high carbohydrates in improving insulin sensitivity.-- Al Pater, alpater@... __________________________________________________