Vitamin D and blood pressure

[Guest guest]

Plasma Vitamin D levels are inversely associated with risk of

hypertension.

Hypertension. 49(5):1063-1069, May 2007

Abstract:

mdash;: Hydroxylation of 25(OH)D to 1,25-dihydroxyvitamin D and

signaling through the vitamin D receptor occur in various tissues not

traditionally involved in calcium homeostasis. Laboratory studies

indicate that 1,25-dihydroxyvitamin D suppresses renin expression and

vascular smooth muscle cell proliferation; clinical studies

demonstrate an inverse association between ultraviolet radiation, a

surrogate marker for vitamin D synthesis, and blood pressure. We

prospectively studied the independent association between measured

plasma 25-hydroxyvitamin D [25(OH)D] levels and risk of incident

hypertension and also the association between predicted plasma 25(OH)D

levels and risk of incident hypertension. Two prospective cohort

studies including 613 men from the Health Professionals' Follow-Up

Study and 1198 women from the Nurses' Health Study with measured

25(OH)D levels were followed for 4 to 8 years. In addition, 2

prospective cohort studies including 38 388 men and 77 531 women with

predicted 25(OH)D levels were followed for 16 to 18 years. During 4

years of follow-up, the multivariable relative risk of incident

hypertension among men whose measured plasma 25(OH)D levels were <15

ng/mL (ie, vitamin D deficiency) compared with those whose levels were

>=30 ng/mL was 6.13 (95% confidence interval [CI]: 1.00 to 37.8).

Among women, the same comparison yielded a relative risk of 2.67 (95%

CI: 1.05 to 6.79). The pooled relative risk combining men and women

with measured 25(OH)D levels using the random-effects model was 3.18

(95% CI: 1.39 to 7.29). Using predicted 25(OH)D levels in the larger

cohorts, the multivariable relative risks comparing the lowest to

highest deciles were 2.31 (95% CI: 2.03 to 2.63) in men and 1.57 (95%

CI: 1.44 to 1.72) in women. Plasma 25(OH)D levels are inversely

associated with risk of incident hypertension.

http://snipurl.com/1mzaf

[Guest guest]

Rodney

Didnt you do a " one mouse " study for a bried period on

your BP and Vit D intake?

How did it compare with this study?

Regards

Jeff

[Guest guest]

Hi Jeff:

LOL. I was afraid you might raise that!

Perhaps it provides evidence of the unreliability of one-mouse

experiments (as if we needed more evidence!)

When I started those experiments I used to take my BP every Saturday

morning at 11:00 am on the same machine at the local drug store. I

would raise my vitamin D intake by 2000 IU a day for three weeks and

watch my blood pressure. Then I would take no D supplements for three

weeks and watch. I was seeing an increase of about 25 points in SBP

after three weeks of supplementation. And reversion to normal with no

D supplements.

Then I bought an Omron machine and have since been taking my BP

daily. All this past winter I was taking more than 1000 IU of D daily

but my 21-day moving average SBP has been between 105 and 100; while

DBP has been between 56 and 62.

I have recently stopped taking the supplements but am getting more

sunshine and there is no very obvious effect on my BP measurements.

The variable which has been very clearly related to BP ever since I

have been paying close attention to it, is body weight. But what

startles me (presumably it must be just an coincidental data

aberration) is that my blood pressure numbers seem to LEAD (!!!) my

weight change by about two weeks. This is really weird. If anyone

can think of a logical explanation for this I would much appreciate

hearing it.

Rodney.

--- In , Jeff Novick <chefjeff40@...>

wrote:

>

> Rodney

>

> Didnt you do a " one mouse " study for a bried period on

> your BP and Vit D intake?

>

> How did it compare with this study?

>

> Regards

> Jeff

>

[Guest guest]

With respect your question about your blood pressure levels *leading*

your weight gain, do your higher calorie foods consumed also tend to

be higher in sodium?

-Dave

> >

> > Rodney

> >

> > Didnt you do a " one mouse " study for a bried period on

> > your BP and Vit D intake?

> >

> > How did it compare with this study?

> >

> > Regards

> > Jeff

> >

>

[Guest guest]

Hi Dave:

I haven't noticed that sodium is a factor in my BP fluctuations. But

thank for raising the issue as that is something I ought to check.

And will.

Rodney.

> > >

> > > Rodney

> > >

> > > Didnt you do a " one mouse " study for a bried period on

> > > your BP and Vit D intake?

> > >

> > > How did it compare with this study?

> > >

> > > Regards

> > > Jeff

> > >

> >

>