More from Fontana and Holloszy

[Guest guest]

Hi folks:

I do not recall this being posted previously:

Exp Gerontol. 2007 Aug;42(8):709-12.

" Caloric restriction in humans. "

Holloszy JO, Fontana L.

Division of Geriatrics and Nutritional Science, Washington University

School of Medicine, 4566 Avenue, Campus Box 8113, St. Louis, MO

63110, USA.

" Studies on mice and rats have demonstrated that calorie restriction

(CR) slows primary aging, has a protective effect against secondary

aging, and markedly decreases the incidence of malignancies. However,

the only way to determine whether CR " works " in humans is to conduct

studies on people. Such studies are difficult to perform in free-

living people. While research on CR in humans is still at an early

stage, a modest amount of information has accumulated. Because it is

not feasible to conduct studies of the effects of CR on longevity in

humans, surrogate measures have to be used. Preliminary information

obtained using this approach provides evidence that CR provides a

powerful protective effect against secondary aging in humans. This

evidence consists of the finding that risk factors for

atherosclerosis and diabetes are markedly reduced in humans on CR.

Humans on CR also show some of the same adaptations that are thought

to be involved in slowing primary aging in rats and mice. These

include a very low level of inflammation as evidenced by low

circulating levels of c-reactive protein and TNFalpha, serum

triiodothyronine levels at the low end of the normal range, and a

more elastic " younger " left ventricle (LV), as evaluated by echo-

doppler measures of LV stiffness. "

PMID: 17482403

Rodney.

[Guest guest]

Hi All, The pdf is availed. Table 1. Atherosclerosis risk factors in CR Society members before and after starting CR=================================================================>>>>>Before CR 1.0±0.3 y) CR 6.5±4.8 y CR=================================================================Body mass index (kg/m2) 23.7±2.6 (33) 20.3±2.0 (28) 19.6±1.6 (33)Total cholesterol (mg/dl) 211±36 (24) 165±33 (16) 159±36 (24)LDL-cholesterol (mg/dl) 124±37 (20) 94±21 (14) 89±30 (20)HDL-cholesterol (mg/dl) 47±8 (20) 59±13 (14) 64±21 (20)Total chol. :HDL-chol. ratio 4.5±1.1 (20) 2.9±0.6 (14) 2.6±0.5 (20)Triglycerides (mg/dl) 134±81 (24) 68±22 (16) 49±14 (24)Systolic blood pressure (mmHg) 131±15 (20) 112±12 (14) 101±9 (20)Diastolic blood pressure (mmHg) 82±9 (20) 71±7 (14) 61±7

(20)=================================================================>>>Values are means±SD. Number of subjects at each timepoint is given in parenthesis. Table 2. Summary of data obtained on CR Society members=================================================================>>> Western Diet Calorie Restricted=================================================================Age (y) (33) 52.3±10 51.4±12Male:female 29:4 29:4Body mass index (kg/m2) (33) 24.8±3.2 19.6±1.6^¶Total body fat (%) (33) 23.1±7 8.4±7^¶Truncal fat (%) (33) 23.4±9.7 4.6±5.7^¶Systolic blood pressure (mm Hg) (33) 130±13 103±12^¶Diastolic blood pressure (mm Hg) (33) 81±9 63±7^¶Total cholesterol (mg/dl) (33) 202±33 162±34^¶LDL-cholesterol (mg/dl) (33) 122±30 86±24^¶HDL-cholesterol (mg/dl) (33) 52±15 64±18*Total cholesterol:HDL-cholesterol ratio 4.2±1.2 2.5±0.5^¶Triglycerides (mg/dl) (33) 143±93

58±18^¶Glucose (mg/dl) (33) 95±9 84±8^¶Insulin (µU/ml) (33) 7.4±6 1.5±0.9^¶TNF-alpha (pg/ml) (28) 1.5±0.9 0.7±0.5*C-reactive protein (mg/L) (31) 1.1±1.2 0.2±0.3^¶TGF-ß1 (ng/ml) (31) 22.1±6.6 14.9±3.1^¶Triodothyronine (ng/dl) (28) 91±13 74±22^¶=================================================================>>>Values are means±SD for the number of subjects given in parenthesis.>>>*P<0.01; ^¶P<0.001 CR versus Western Diet.Rodney <perspect1111@...> wrote: Hi

folks:I do not recall this being posted previously:Exp Gerontol. 2007 Aug;42(8):709-12."Caloric restriction in humans."Holloszy JO, Fontana L.Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 4566 Avenue, Campus Box 8113, St. Louis, MO 63110, USA."Studies on mice and rats have demonstrated that calorie restriction (CR) slows primary aging, has a protective effect against secondary aging, and markedly decreases the incidence of malignancies. However, the only way to determine whether CR "works" in humans is to conduct studies on people. Such studies are difficult to perform in free-living people. While research on CR in humans is still at an early stage, a modest amount of information has accumulated. Because it is not feasible to conduct studies of the effects of CR on longevity in humans, surrogate measures have to be used. Preliminary

information obtained using this approach provides evidence that CR provides a powerful protective effect against secondary aging in humans. This evidence consists of the finding that risk factors for atherosclerosis and diabetes are markedly reduced in humans on CR. Humans on CR also show some of the same adaptations that are thought to be involved in slowing primary aging in rats and mice. These include a very low level of inflammation as evidenced by low circulating levels of c-reactive protein and TNFalpha, serum triiodothyronine levels at the low end of the normal range, and a more elastic "younger" left ventricle (LV), as evaluated by echo-doppler measures of LV stiffness."PMID: 17482403 Rodney.

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